Protective Effect of Aloe vera and Croton palanostigma against Acute Gastric Mucosa Injury Induced by Ethanol in Rats

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OBJECTIVE: The gastric protective abilities of Croton palanostigma (dragonis blood), Aloe vera, sucralfate, and antacid against acute ethanol-induced necrosis by means of a standard experimental model in rats, were compared. MATERIAL AND METHODS: A pretreatment with either saline solution; 0,8 mL/kg...

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Detalles Bibliográficos
Autores: Ayala Pío, Salomón, Díaz, David, Palomino, Manuel, Armas, Segundo, Paz, Juan
Formato: artículo
Fecha de Publicación:1999
Institución:Universidad Nacional Mayor de San Marcos
Repositorio:Revistas - Universidad Nacional Mayor de San Marcos
Lenguaje:español
OAI Identifier:oai:ojs.csi.unmsm:article/4498
Enlace del recurso:https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4498
Nivel de acceso:acceso abierto
Materia:Gastric Mucosa
Plants
Medicinal
Anti-Ulcer Agents
Disease Models
Animal
Mucosa Gástrica
Plantas Medicinales
Agentes Antiulcerosos
Modelos Animales de Enfermedad
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spelling Protective Effect of Aloe vera and Croton palanostigma against Acute Gastric Mucosa Injury Induced by Ethanol in RatsEfecto Protector de Croton palanostigma y Aloe frente a Injuria Aguda de Mucosa Gástrica inducida por Etanol en RatasAyala Pío, SalomónDíaz, DavidPalomino, ManuelArmas, SegundoPaz, JuanGastric MucosaPlantsMedicinalAnti-Ulcer AgentsDisease ModelsAnimalMucosa GástricaPlantas MedicinalesAgentes AntiulcerososModelos Animales de EnfermedadOBJECTIVE: The gastric protective abilities of Croton palanostigma (dragonis blood), Aloe vera, sucralfate, and antacid against acute ethanol-induced necrosis by means of a standard experimental model in rats, were compared. MATERIAL AND METHODS: A pretreatment with either saline solution; 0,8 mL/kg or 0,4 mL/kg C. palanostigma; 7,5 mL/kg or 3,2 mL/kg A. vera; 500 mg/kg sucralfate; or antacid was given to 56 fasted rats. Then we accomplished an intragastric administration of 2 mL of 100% ethanol one hour later. A gastrectomy was performed four hours later followed by a macroscopic and histologycal evaluation of the gastric lesions. RESULTS: C. palanostigma pretreatment resulted in a significant reduction of ethanol-induced gastric mucosa Protective effect of Croton palanostigma, Aloe vera, SUCRALFATE AND ANTACID AGAINST ACUTE ETHANOL-INDUCED GASTRIC MUCOSA necrosis. A. vera failed to show mucosal protection. Sucralfate showed a significant protective effect, while antacid exhibited a lesser protective effect. CONCLUSION: In the present study, C. palanostigma showed an important protective effect, being potentially useful as a therapeutic tool.OBJETIVOS: Evaluar el grado de protección frente a la necrosis de la mucosa gástrica inducida por etanol con Croton palanostigma (Sangre de Grado) y Aloe vera, y compararlo con el de sucralfato y una suspensión de antiácido (AlOH3 +MgOH3+simeticona), en un modelo experimental estandarizado en ratas. MATERIAL Y MÉTODOS: Se evaluó a 56 animales, administrándoles en ayunas uno de 7 pretratamientos: solución salina, C. palanostigma (0,4 ó 0,8 mL/kg), A. vera (7,5 ó 3,2 mL/kg), sucralfato (500 mg/kg) o antiácido. Una hora más tarde, se administró por vía intragástrica 2 mL de etanol al 100%. Se realizó una evaluación cualitativa y cuantitativa, macroscópica y microscópica, de las lesiones gástricas. RESULTADOS: El pretratamiento con C. palanostigma redujo significativamente la aparición de necrosis hemorrágica inducida por etanol, A. vera no presentó efecto protector, mientras que sí lo presentaron el sucralfato, en grado significativo, y el antiacido, en menor grado. CONCLUSIÓN: En nuestras condiciones experimentales, Croton palanostigma presentó un importante efecto protector y potencial terapéutico.Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana1999-03-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/449810.15381/anales.v60i1.4498Anales de la Facultad de Medicina; Vol. 60 No. 1 (1999); 22-29Anales de la Facultad de Medicina; Vol. 60 Núm. 1 (1999); 22-291609-94191025-5583reponame:Revistas - Universidad Nacional Mayor de San Marcosinstname:Universidad Nacional Mayor de San Marcosinstacron:UNMSMspahttps://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4498/3582Derechos de autor 1999 Salomón Ayala Pío, David Díaz, Manuel Palomino, Segundo Armas, Juan Pazhttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessoai:ojs.csi.unmsm:article/44982020-04-13T20:35:22Z
dc.title.none.fl_str_mv Protective Effect of Aloe vera and Croton palanostigma against Acute Gastric Mucosa Injury Induced by Ethanol in Rats
Efecto Protector de Croton palanostigma y Aloe frente a Injuria Aguda de Mucosa Gástrica inducida por Etanol en Ratas
title Protective Effect of Aloe vera and Croton palanostigma against Acute Gastric Mucosa Injury Induced by Ethanol in Rats
spellingShingle Protective Effect of Aloe vera and Croton palanostigma against Acute Gastric Mucosa Injury Induced by Ethanol in Rats
Ayala Pío, Salomón
Gastric Mucosa
Plants
Medicinal
Anti-Ulcer Agents
Disease Models
Animal
Mucosa Gástrica
Plantas Medicinales
Agentes Antiulcerosos
Modelos Animales de Enfermedad
title_short Protective Effect of Aloe vera and Croton palanostigma against Acute Gastric Mucosa Injury Induced by Ethanol in Rats
title_full Protective Effect of Aloe vera and Croton palanostigma against Acute Gastric Mucosa Injury Induced by Ethanol in Rats
title_fullStr Protective Effect of Aloe vera and Croton palanostigma against Acute Gastric Mucosa Injury Induced by Ethanol in Rats
title_full_unstemmed Protective Effect of Aloe vera and Croton palanostigma against Acute Gastric Mucosa Injury Induced by Ethanol in Rats
title_sort Protective Effect of Aloe vera and Croton palanostigma against Acute Gastric Mucosa Injury Induced by Ethanol in Rats
dc.creator.none.fl_str_mv Ayala Pío, Salomón
Díaz, David
Palomino, Manuel
Armas, Segundo
Paz, Juan
author Ayala Pío, Salomón
author_facet Ayala Pío, Salomón
Díaz, David
Palomino, Manuel
Armas, Segundo
Paz, Juan
author_role author
author2 Díaz, David
Palomino, Manuel
Armas, Segundo
Paz, Juan
author2_role author
author
author
author
dc.subject.none.fl_str_mv Gastric Mucosa
Plants
Medicinal
Anti-Ulcer Agents
Disease Models
Animal
Mucosa Gástrica
Plantas Medicinales
Agentes Antiulcerosos
Modelos Animales de Enfermedad
topic Gastric Mucosa
Plants
Medicinal
Anti-Ulcer Agents
Disease Models
Animal
Mucosa Gástrica
Plantas Medicinales
Agentes Antiulcerosos
Modelos Animales de Enfermedad
description OBJECTIVE: The gastric protective abilities of Croton palanostigma (dragonis blood), Aloe vera, sucralfate, and antacid against acute ethanol-induced necrosis by means of a standard experimental model in rats, were compared. MATERIAL AND METHODS: A pretreatment with either saline solution; 0,8 mL/kg or 0,4 mL/kg C. palanostigma; 7,5 mL/kg or 3,2 mL/kg A. vera; 500 mg/kg sucralfate; or antacid was given to 56 fasted rats. Then we accomplished an intragastric administration of 2 mL of 100% ethanol one hour later. A gastrectomy was performed four hours later followed by a macroscopic and histologycal evaluation of the gastric lesions. RESULTS: C. palanostigma pretreatment resulted in a significant reduction of ethanol-induced gastric mucosa Protective effect of Croton palanostigma, Aloe vera, SUCRALFATE AND ANTACID AGAINST ACUTE ETHANOL-INDUCED GASTRIC MUCOSA necrosis. A. vera failed to show mucosal protection. Sucralfate showed a significant protective effect, while antacid exhibited a lesser protective effect. CONCLUSION: In the present study, C. palanostigma showed an important protective effect, being potentially useful as a therapeutic tool.
publishDate 1999
dc.date.none.fl_str_mv 1999-03-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4498
10.15381/anales.v60i1.4498
url https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4498
identifier_str_mv 10.15381/anales.v60i1.4498
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4498/3582
dc.rights.none.fl_str_mv Derechos de autor 1999 Salomón Ayala Pío, David Díaz, Manuel Palomino, Segundo Armas, Juan Paz
https://creativecommons.org/licenses/by-nc-sa/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 1999 Salomón Ayala Pío, David Díaz, Manuel Palomino, Segundo Armas, Juan Paz
https://creativecommons.org/licenses/by-nc-sa/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana
publisher.none.fl_str_mv Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana
dc.source.none.fl_str_mv Anales de la Facultad de Medicina; Vol. 60 No. 1 (1999); 22-29
Anales de la Facultad de Medicina; Vol. 60 Núm. 1 (1999); 22-29
1609-9419
1025-5583
reponame:Revistas - Universidad Nacional Mayor de San Marcos
instname:Universidad Nacional Mayor de San Marcos
instacron:UNMSM
instname_str Universidad Nacional Mayor de San Marcos
instacron_str UNMSM
institution UNMSM
reponame_str Revistas - Universidad Nacional Mayor de San Marcos
collection Revistas - Universidad Nacional Mayor de San Marcos
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 13.949868
Protective Effect of Aloe vera and Croton palanostigma against Acute Gastric Mucosa Injury Induced by Ethanol in Rats
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