This experimental study was to evaluate the effect of prednisone on the ratio of the length of tooth movement in rats (Rattus norvegicus). The evaluation of this relationship was performed in 20 male Wistar rats 12 weeks of age, weighing 225 ± 25 g, to which adapted a orthodontic breaker in their upper central incisors, were then randomly divided into two groups: control (physiological saline to 2 mL/kg) and experimental (prednisone 20 mg/kg ip), the treatment began five days before placement of the device and then to the first, third and fifth day. With a gauge, was measured the interincisisor distance to finish placing the device, as so as to the first, third, fifth and seventh day. On the 1st day of testing, the control group and the experimental group had a interincisiva distance 1,13 ± 0,18 mm and 0,24 ± 0,09 mm and the 7th day was 1,76 ± 0,14 mm and 1,56 ± 0,20 mm, respectivel...

This experimental study was to evaluate the effect of prednisone on the ratio of the length of tooth movement in rats (Rattus norvegicus). The evaluation of this relationship was performed in 20 male Wistar rats 12 weeks of age, weighing 225 ± 25 g, to which adapted a orthodontic breaker in their upper central incisors, were then randomly divided into two groups: control (physiological saline to 2 mL/kg) and experimental (prednisone 20 mg/kg ip), the treatment began five days before placement of the device and then to the first, third and fifth day. With a gauge, was measured the interincisisor distance to finish placing the device, as so as to the first, third, fifth and seventh day. On the 1st day of testing, the control group and the experimental group had a interincisiva distance 1,13 ± 0,18 mm and 0,24 ± 0,09 mm and the 7th day was 1,76 ± 0,14 mm and 1,56 ± 0,20 mm, respectivel...

Objective of this experimental study was to determine the subchronic toxicity and possible teratogenic effect of ethanol extract from Chuquiraga spinosa (huamanpinta) in Holtzman rats. Was used for the determination of subchronic toxicity 60 rats (30 males and 30 females); the first, control, group received saline solution 4 mL/kg and the second group extract at 200 mg/kg during four consecutive months, making evaluation hematological and biochemical the second, third and fourth month. At the end of the trial (fourth month) was made pathological examination. The determination of possible teratogenic effect was performed using 40 female rats and ten male rats. Female rats recived 200 mg/kg daily by a month before mating and until the birth of brood, was evaluated the number implementations to uterine horns level, live and dead fetuses, and external morphological abnormalities of the offsp...

El presente estudio tuvo como objetivo determinar la toxicidad subcrónica y posible efecto teratogénico del extracto etanólico de Chuquiraga spinosa (huamanpinta) en ratas de raza Holtzmann. Para la determinación de la toxicidad subcrónica se utilizaron 60 ratas (30 machos y 30 hembras); el primer grupo, control, recibió suero fisiológico 4 mL/kg y el segundo grupo 200 mg/kg de extracto durante cuatro meses consecutivos, realizando la evaluación hematológica y bioquímica al segundo, tercer y cuarto mes. Al final del ensayo (cuarto mes) se realizó el examen anatomopatológico. La determinación del posible efecto teratogénico se realizó utilizando 40 ratas hembras y diez ratas machos. Las ratas hembras recibieron 200 mg/kg diariamente durante un mes antes del apareamiento y, hasta el nacimiento de las crías, se evaluaron el número implantaciones a nivel de cuernos uterinos,...