Introduction: Cardiovascular diseases are major causes de death in the world.The hepatic lipase (HL) gene promoter region presents a C-514T functionalpolymorphism related to enzyme activity, variation of lipoproteins levels andpossible cardiovascular disease risk. Objectives: To determine the associationof HL gene promoter region polymorphism with both nutritional indicators andlipoproteins levels in a healthy Peruvian sample. Design: Descriptive, transversal,associative study. Setting: Alberto Guzman Barron Biochemistry and NutritionResearch Center, Faculty of Medicine, Universidad Nacional Mayor de San Marcos.Participants: Ninety healthy male and female volunteers aged 18 to 58 years.Interventions: Genomic DNA was obtained from serum samples accordingto standard methodology. Anthropometric measurements and lipid profile byenzymatic methods were performed. Polymorphism C-514T in the HL ...

Introduction: Dopaminergic catechol-o-methyl transferase (COMT) gene has a functional polymorphism Val108/158Met that originates enzyme variants that catalyze o-methylation of active catecholamines and participates in drugs and neurotransmitters metabolism including L-dopa, norepinephrine, epinephrine and dopamine and thus may be associated to neuropsychiatric conditions. Objectives: To determine COMT gene genotypes and alleles frequencies in mestizo Peruvian population healthy subjects and its importance in neuropsychiatric genetic studies. Design: Descriptive, observational, transversal study. Setting: Alberto Guzman Barron Biochemistry and Nutrition Research Center, Faculty of Medicine, Universidad Nacional Mayor de San Marcos. Participants: One hundred and six healthy subjects, male and female volunteers with informed consent, without family relationship or mental and neurological di...