The disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is known as Coronavirus Disease 2019 (COVID-19). Its involvement is mainly respiratory, but various neurological manifestations have been described. The neurotropism and potential neuropathotogenic role of SARS-CoV-2 is based on animal models and cases of neurological condition described in other coronaviruses, as well as recent reports of specific neurological syndromes related to COVID-19, including ischemic stroke. The Spanish Society of Neurology described ischemic stroke as the second most frequent neurological manifestation in patients with COVID-19. Likewise, the state of hyperinflammation and blood hypercoagulability triggered by COVID-19 would increase the risk of prothrombotic events. We report 3 cases of peruvian patients who presented ischemic stroke associated with COVID-19: we describe the cl...

Se reporta el caso de un paciente de 34 años, buzo de profesión, hospitalizado por presentar de forma súbita confusión, debilidad generalizada, dolor intenso seguido de paraplejía y retención urinaria luego de emerger rápidamente desde una profundidad aproximada de 42 metros. El paciente fue admitido 48 horas después del evento habiendo completado dos sesiones de terapia de descompresión. Al examen se evidenció paraplejía flácida arrefléxica con nivel sensitivo a nivel de D5 global, reflejo plantar extensor bilateral y retención urinaria. En la resonancia magnética se evidenció incremento del calibre medular con alteración de señal en su diámetro anteroposterior, el cual es visto como hiperintensidad heterogénea en la secuencia T2 y STIR desde D2 hasta D11, sin dilatación del canal medular, compatible con lesión isquémica secundaria a enfermedad descompresiva. Reci...

In the context of the COVID-19 pandemic, atypical clinical forms have been described, in which extra-respiratory symptoms predominate; among them, cases of concurrent neurological manifestations have been reported. Based on the coronavirus identification in the central nervous system in the 2002 SARS-CoV outbreak, a potential neurotropism of SARS-CoV-2 has been raised. Few patients with acute encephalitis associated with SARS-CoV-2 have been described in the world literature. In this report we present two cases of Peruvian patients with acute encephalitis concurrent to COVID-19, we reviewed the literature and discussed the possible mechanisms of neurotropism and neuroinvasion.