Acute encephalitis associated with SARS-CoV-2: first case report in Peru

• Autores: Barreto-Acevedo, Elliot, Mariños, Evelyn, Espino, Poul, Troncoso, Jhonatan, Urbina, Luis, Valer, Nashely
• Formato: artículo
• Fecha de Publicación: 2020
• Institución: Universidad Peruana Cayetano Heredia
• Repositorio: Revistas - Universidad Peruana Cayetano Heredia
• Lenguaje: español
• OAI Identifier: oai:revistas.upch.edu.pe:article/3754
• Enlace del recurso: https://revistas.upch.edu.pe/index.php/RNP/article/view/3754
• Nivel de acceso: acceso abierto
• Materia: encephalitis; COVID-19; Peru; encefalitis; COVID-19; Perú

In the context of the COVID-19 pandemic, atypical clinical forms have been described, in which extra-respiratory symptoms predominate; among them, cases of concurrent neurological manifestations have been reported. Based on the coronavirus identification in the central nervous system in the 2002 SARS-CoV outbreak, a potential neurotropism of SARS-CoV-2 has been raised. Few patients with acute encephalitis associated with SARS-CoV-2 have been described in the world literature. In this report we present two cases of Peruvian patients with acute encephalitis concurrent to COVID-19, we reviewed the literature and discussed the possible mechanisms of neurotropism and neuroinvasion.