Diabetes is one of the most frequent pathologies with repercussions at the systemic level, irreversible and with high prevalence in the world. Currently in Ecuador, there is an average of 800,000 diabetics, of whom 100,000 are in treatment, according to health authorities and the Juvenile Diabetes Foundation of Ecuador. This review seeks to update knowledge in the area of health, both in medicine and in dentistry, forcing us to have a review of current data on the relationship between periodontal disease and type II diabetes mellitus, and how These two pathologies can go hand in hand and affect the oral and systemic environment, relating them to the histological changes and chemical mediators in the oral environment that are accentuated by the presence of periodontal disease and diabetes, whether controlled or not. Databases were revised in Pubmed and ScIELO bibliographic sources, placin...