Determinar las interacciones farmacológicas entre el extracto etanólico de la corteza del Maytenus Macrocarpa “Chuchuhuasi” y fármacos antidepresivos en ratones albinos. Ratones albinos machos de peso promedio de 30g, fueron asignados por muestreo aleatorio simple en 21 grupos experimentales, recibiendo por vía oral Fluoxetina (20 y 40 mg/kg), amitriptilina (10 y 15 mg/kg), extracto etanólico de las hojas de Maytenus macrocarpa “Chuchuhuasi” (500, 750, 1000 mg/kg) y 12 grupos de interacción entre Chuchuhuasi y lo antidepresivos usados. Empleándose la prueba de nado forzado, y Test de Irwin para evaluar el efecto neurofarmacológico. El test de ANOVA y Kruskal-Wallis resultó p<0.05 para los grupos experimentales con distribución gaussiana y no gaussiana respectivamente. Asimismo se ejecutó los test de Tukey y Dunn´s obteniendo p<0.05 en la comparación de los siguientes...

Introducción: estudios de árboles del género Maytenus, especies forsskaoliana, ilicifolia y krukovii revelan efectos depresores a nivel cardiovascular sobre la presión arterial y frecuencia cardiaca. Objetivos: analizar experimentalmente los efectos de las hojas de Maytenus macrocarpa "chuchuhuasi" sobre la frecuencia cardiaca, patrones electrocardiográficos, frecuencia respiratoria, y temperatura. Métodos: investigación de tipo exploratorio, analítico y experimental. Se utilizaron ratas albinas en 9 grupos de 8 ratas. Grupo 1 (control: Halatal), grupo 2 (placebo: agua destilada), grupo 3 (adrenalina), grupo 4 (atropina), grupo 5 (acetilcolina), grupo 6 (propranolol), grupo 7 (chuchuhuasi 500 mg/kg), grupo 8 (chuchuhuasi 1 000 mg/kg) y grupo 9 (chuchuhuasi 1 500 mg/kg). La temperatura rectal se midió con termómetro de mercurio, la frecuencia respiratoria, por conteo directo; el...

Introduction: The restrictive measures chosen to reduce COVID-19 infection could maintain and even increase high levels of depression and violence, putting at risk both the fetus and the mother. Objective: To identify the prevalence and factors associated with depression in pregnant Peruvians during the COVID-19 pandemic. The study: Observational-analytical study, with 267 pregnant women in their third trimester of pregnancy. Conducted during the month of January 2021, applying the Edinburgh Scale and the Spanish version of the Index of Spouse Abuse-19 (ISA-19). Findings: 62.17% of pregnant women presented depression and 17.6% spousal violence during pregnancy. Spousal violence, the history of at least one lost pregnancy and planned pregnancy, were associated with depression. Conclusions: Spousal violence increases the prevalence of depression during pregnancy as opposed to a planned pre...

Introduction: The restrictive measures chosen to reduce COVID-19 infection could maintain and even increase high levels of depression and violence, putting at risk both the fetus and the mother. Objective: To identify the prevalence and factors associated with depression in pregnant Peruvians during the COVID-19 pandemic. The study: Observational-analytical study, with 267 pregnant women in their third trimester of pregnancy. Conducted during the month of January 2021, applying the Edinburgh Scale and the Spanish version of the Index of Spouse Abuse-19 (ISA-19). Findings: 62.17% of pregnant women presented depression and 17.6% spousal violence during pregnancy. Spousal violence, the history of at least one lost pregnancy and planned pregnancy, were associated with depression. Conclusions: Spousal violence increases the prevalence of depression during pregnancy as opposed to a planned pre...

Introduction. COVID-19 infection in high-altitude districts has been a subject of study for several researchers since the incidence and transmission capacity of this virus is lower at higher altitudes. Objective. Compare the lethality of COVID-19 at different altitudes in different districts of Peru. Material and Methods. We conducted a secondary descriptive observational study based on data from the Ministry of Health, we took as a unit of analysis 1874 districts of Peru, taking the fatality rate as the dependent variable. In our main analysis, we developed a crude and cofactor-adjusted linear regression between the COVID-19 case fatality rate per million inhabitants and altitude of residence of the districts of Peru, we also carried out two sensitivity analyzes, to provide different approaches to the problem, adding two multivariate regression models as a sensitivity analysis, all the ...

Objetivos. Evaluar la frecuencia de publicación y sus factores asociados en docentes universitarios de investigación científica de escuelas de Medicina del Perú. Materiales y métodos. Estudio de corte transversal analítico. Se incluyó a todos los docentes universitarios de los cursos de investigación de las 32 escuelas de medicina del Perú en el año 2011. La búsqueda de publicaciones se realizó mediante Google Scholar, SCOPUS y Medline. Se calculó las razones de prevalencias crudas y ajustadas (RPa) con intervalos de confianza al 95% mediante regresión de Poisson simple y múltiple con varianza robusta. Resultados. De los 201 docentes universitarios, 43,8% nunca ha publicado un artículo en una revista, 26,9% publicó un artículo original en una revista indizada en Medline y 16,4% lo hizo en los últimos dos años. Solo 3,0% han sido autores corresponsales en alguna revist...

Introduction. COVID-19 infection in high-altitude districts has been a subject of study for several researchers since the incidence and transmission capacity of this virus is lower at higher altitudes. Objective. Compare the lethality of COVID-19 at different altitudes in different districts of Peru. Material and Methods. We conducted a secondary descriptive observational study based on data from the Ministry of Health, we took as a unit of analysis 1874 districts of Peru, taking the fatality rate as the dependent variable. In our main analysis, we developed a crude and cofactor-adjusted linear regression between the COVID-19 case fatality rate per million inhabitants and altitude of residence of the districts of Peru, we also carried out two sensitivity analyzes, to provide different approaches to the problem, adding two multivariate regression models as a sensitivity analysis, all the ...

Carta al Editor (sin resumen)

Carta al Editor (sin resumen)

Carta al Editor (sin resumen)

Carta al Editor (sin resumen)

OBJETIVO: Determinar las posibles interacciones farmacológicas de las hojas de Maytenus macrocarpa, con fármacos estimulantes e inhibitorios de la motilidad intestinal. MÉTODOS: Se utilizaron 110 ratones albinos machos, con pesos medios de 25 g, se empleó el método de Arbos y col, se administró carbón activado al 5 % vía oral, dosis de 0.1ml/10g, como marcador intestinal. Los grupos experimentales fueron: control (agua destilada 0,3ml), hojas de chuchuhuasi 1 (500mg/kg), hojas de chuchuhuasi 2 (3000mg/kg), atropina (1,5mg/kg), loperamida (5mg/kg), neostigmina (0,4mg/kg), metoclopramida (10mg/kg), hojas de chuchuhuasi 1 con metoclopramida, hojas de chuchuhuasi 1 con loperamida, hojas de chuchuhuasi 2 con metoclopramida y hojas de chuchuhuasi 2 con loperamida. Para la validación estadística se usó la prueba de Wilconxon, ANOVA y Tukey. RESULTADOS: El porcentaje de recorrido inte...