1
artículo
Publicado 2018
Enlace
Enlace
Objectives: The aim was to determine the association between tacrolimus levels and early renal graft function, acute rejection and infections in the first month after early kidney transplantation. Methods: Retrospective, observational and analytical study. Review of records of kidney transplant patients over 18 years of age during 2016, who met the inclusion criteria (n = 36). The descriptive and analytical statistics were with STATA 15, significance p <0.05. Results: Age 41.6 ± 15.3, males 52.78%, deceased donor 77.78%, 86.11% had ≤ 3 incompatibilities HLA and PRA 0%. They received induction 97.22%. Tacrolimus dose (TAC C) on the seventh day was 8.7 ± 3.4 ng / ml. The 16.66% were donors of expanded criteria, 22.22% with delayed graft function, acute tubular necrosis (6/36), anticalcineurin toxicity (10/36) and acute cellular rejection IA (1/36). The overall TAC C / D ratio <1....
2
artículo
Publicado 2018
Enlace
Enlace
ABSTRACT Fabry disease is a lysosomal storage disease caused by alpha galactosidase A enzyme deficiency. The pattern of inheritance is X-linked. The clinical presentation has a variety of symptoms and signs; and a classic clinical variant and non-classical clinical variants such as renal or cardiac have been described. The diagnosis is clinical and laboratory and even molecular and in some cases histology of the compromised organ is needed. The treatment in recent years remains symptomatic therapy and with enzyme replacement therapy; although chaperones are already available for the treatment of a group of patients with "amenable" mutations and they are studying gene therapy and nanotechnology. It must have a multidisciplinary approach, given the variety of symptoms and signs in its presentation. Early detection and early initiation of therapy could improve quality of life and limit the ...
3
artículo
Publicado 2018
Enlace
Enlace
Objectives: The aim was to determine the association between tacrolimus levels and early renal graft function, acute rejection and infections in the first month after early kidney transplantation. Methods: Retrospective, observational and analytical study. Review of records of kidney transplant patients over 18 years of age during 2016, who met the inclusion criteria (n = 36). The descriptive and analytical statistics were with STATA 15, significance p <0.05. Results: Age 41.6 ± 15.3, males 52.78%, deceased donor 77.78%, 86.11% had ≤ 3 incompatibilities HLA and PRA 0%. They received induction 97.22%. Tacrolimus dose (TAC C) on the seventh day was 8.7 ± 3.4 ng / ml. The 16.66% were donors of expanded criteria, 22.22% with delayed graft function, acute tubular necrosis (6/36), anticalcineurin toxicity (10/36) and acute cellular rejection IA (1/36). The overall TAC C / D ratio <1....
4
artículo
Publicado 2018
Enlace
Enlace
ABSTRACT Fabry disease is a lysosomal storage disease caused by alpha galactosidase A enzyme deficiency. The pattern of inheritance is X-linked. The clinical presentation has a variety of symptoms and signs; and a classic clinical variant and non-classical clinical variants such as renal or cardiac have been described. The diagnosis is clinical and laboratory and even molecular and in some cases histology of the compromised organ is needed. The treatment in recent years remains symptomatic therapy and with enzyme replacement therapy; although chaperones are already available for the treatment of a group of patients with "amenable" mutations and they are studying gene therapy and nanotechnology. It must have a multidisciplinary approach, given the variety of symptoms and signs in its presentation. Early detection and early initiation of therapy could improve quality of life and limit the ...
5
artículo
Publicado 2022
Enlace
Enlace
Antecedentes y objetivo: La insuficiencia renal es una de las complicaciones extrapulmonares más frecuente en pacientes hospitalizados con COVID-19 condicionando peores desenlaces. Sin embargo, estudios comparan pacientes con insuficiencia renal aguda (IRA) o crónica (ERC) con pacientes sanos. Determinar características clínicas de pacientes con COVID-19 e insuficiencia renal hospitalizados y evaluar el efecto del tipo de insuficiencia renal y el recibir hemodiálisis en los desenlaces clínicos negativos. Métodos: Cohorte descriptiva que incluyó pacientes con algún tipo de insuficiencia renal y COVID-19 hospitalizados durante marzo y julio del 2020, que tuvieron una interconsulta con nefrología. La insuficiencia renal se clasificó como aguda, crónica, y crónica en estadio V con hemodiálisis crónica. Se recolectó información sobre mortalidad, uso de inotrópicos, ventilaci...
6
artículo
Publicado 2022
Enlace
Enlace
Introduction: Kidney failure is one of the most frequent extrapulmonary complications in patients hospitalized with COVID-19, leading to poorer outcomes, and this may have serious consequences for the Peruvian health system. Nonetheless, there are studies comparing patients with acute kidney failure (AKF) and chronic kidney failure (CKF) against healthy subjects. Objective: To determine the clinical characteristics of hospitalized patients with COVID-19 and kidney failure, and to assess the effect of the type of kidney failure and undergo hemodialysis with respect to negative clinical outcomes. Methods: This is a descriptive cohort study that included patients with some kind of kidney failure and COVID-19 who were hospitalizedbetween March and June 2020, and who had a consultation with the nephrology service. Kidney failure was classified as acute, chronic, and stage V chronic undergoing...
7
artículo
Publicado 2022
Enlace
Enlace
Introducción: La insuficiencia renal es una de las complicaciones extrapulmonares más frecuente en pacientes hospitalizados con COVID-19 condicionando peores desenlaces que podría afectar al sistema de salud en Perú. Sin embargo, estudios comparan pacientes con insuficiencia renal aguda (IRA) o crónica (ERC) con pacientes sanos. Objetivo: Determinar características clínicas de pacientes con COVID-19 e insuficiencia renal hospitalizados y evaluar el efecto del tipo de insuficiencia renal y el recibir hemodiálisis en los desenlaces clínicos negativos. Métodos:Cohorte descriptiva incluyó pacientes con algún tipo de insuficiencia renal y COVID-19 hospitalizados durante marzo y julio del 2020, que tuvieron una interconsulta con nefrología. La insuficiencia renal se clasificó como aguda, crónica, y crónica en estadio V con hemodiálisis crónica. Se recolectó información sobr...
8
artículo
Publicado 2022
Enlace
Enlace
Introduction: Kidney failure is one of the most frequent extrapulmonary complications in patients hospitalized with COVID-19, leading to poorer outcomes, and this may have serious consequences for the Peruvian health system. Nonetheless, there are studies comparing patients with acute kidney failure (AKF) and chronic kidney failure (CKF) against healthy subjects. Objective: To determine the clinical characteristics of hospitalized patients with COVID-19 and kidney failure, and to assess the effect of the type of kidney failure and undergo hemodialysis with respect to negative clinical outcomes. Methods: This is a descriptive cohort study that included patients with some kind of kidney failure and COVID-19 who were hospitalizedbetween March and June 2020, and who had a consultation with the nephrology service. Kidney failure was classified as acute, chronic, and stage V chronic undergoing...
9
artículo
Publicado 2022
Enlace
Enlace
Introducción: El presente artículo resume la guía de práctica clínica (GPC) para el tamizaje y manejo de los pacientes desnutridos o en riesgo de desnutrición del Seguro Social del Perú (EsSalud). Objetivo: Proveer recomendaciones clínicas basadas en evidencia para el tamizaje y manejo de pacientes desnutridos o en riesgo de desnutrición en EsSalud. Métodos: Se conformó un grupo elaborador de la guía (GEG) que incluyó profesionales de la salud y metodólogos. El GEG formuló 9 preguntas clínicas a ser respondidas por la presente GPC. Se realizó búsquedas sistemáticas de revisiones sistemáticas y cuando fue considerado pertinentes estudios primarios. Se seleccionó la evidencia para responder cada una de las preguntas clínicas planteadas. La certeza de la evidencia fue evaluada usando la metodología Grading of Recommendations Assessment, Development, and Evaluation (GR...
10
artículo
Publicado 2022
Enlace
Enlace
Introduction: This article summarizes the clinical practice guide (CPG) for the screening and management of malnourished patients or patients at risk of malnutrition in the Social Security of Peru (EsSalud). Objective: To provide clinical recommendations based on evidence for the screening and management of malnourished patients or patients at risk of malnutrition in EsSalud. Methods: A CPG for the screening, management and monitoring of malnourished patients or patients at risk of malnutrition in EsSalud was developed. To this end, a guideline development group (local GDG) was established, including medical specialists and methodologists. The local GDG formulated 9 clinical questions to be answered by this CPG. Systematic searches of systematic reviews and -when it was considered pertinent- primary studies were conducted in Pubmed and CENTRAL during 2021. The evidence to answer each of ...
11
artículo
Publicado 2021
Enlace
Enlace
Introducción: El presente artículo resume la guía de práctica clínica (GPC) para el tratamiento farmacológico inicial nefritis lúpica en el Seguro Social del Perú (EsSalud). Objetivo: Proveer recomendaciones clínicas basadas en evidencia para tratamiento farmacológico inicial de adultos con nefritis lúpica clase I a V no refractarios en EsSalud. Material y Métodos: Se conformó un grupo elaborador de la guía (GEG) que incluyó médicos especialistas y metodólogos, el cual formuló preguntas clínicas. Se realizaron búsquedas sistemáticas de revisiones sistemáticas y –cuando fue considerado pertinente– estudios primarios en PubMed durante el 2021. Se seleccionó la evidencia para responder cada una de las preguntas clínicas planteadas. Se evaluó la certeza de evidencia usando la metodología Grading of Recommendations Assessment, Development, and Evaluation (GRADE)....
12
artículo
Publicado 2021
Enlace
Enlace
Background: This article summarizes the clinical practice guideline (CPG) for the initial pharmacological treatment of lupus nephritis in the Social Security of Peru (EsSalud). Objective: To provide evidence-based clinical recommendations for initial pharmacological treatment of non-refractory adults with class I to V lupus nephritis in EsSalud. Material and Methods: A guideline development group (GDG) was formed, which included specialist physicians and methodologists, who formulated clinical questions. Systematic searches were conducted for systematic reviews and - when deemed relevant - primary studies in PubMed during 2021. Evidence was selected to answer each of the clinical questions posed. The certainty of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. In periodic working meetings, the GEG used the GRADE meth...
