Introducción:Elobjetivodelestudioestábasadoendeterminarsielusodeantibióticoterapiaempíricaaumentaelriesgodemuerteenlospacientesadultosmayoresde18añoshospitalizadosconCOVID-19.Métodos:Serealizóunarevisiónsistemáticaymeta-análisis,paralocualsetomóencuentaestudiosretrospectivosyprospectivos.ParalabúsquedasistemáticaseusaronlasbasesdedatoselectrónicasMedline/PubMed,Embase,LILACSyCINAHLenelperiododediciembre2019amayodel2021.SecalcularonlosOddsRatioylosintervalosdeconfianzaal95%utilizandoelefectoaleatorio,enfuncióndequeexistaonoheterogeneidad,seelaboróelgráficodeFunnelPlotparaevaluarelriesgodesesgo.Resultados:Selocalizaron528artículos,quecumplieronconloscriteriosdeinclusiónyexclusión,seevaluólaelegibilidaddelostextoscompletosde90estudios,deloscualessetuvocomoresultado10artículos.ElOddsRatiodelos10estudiosesde1,55(1,20-2,01),afavordelnousodeantibióticos,conunI2deheterogen...

El estudio tuvo como objetivo conocer los determinantes de la salud pública asociados a infecciones por bacterias multirresistentes en un hospital de la Región Lambayeque. El tipo de estudio fue cuantitativo, observacional, corte longitudinal, de casos y controles. La población por los pacientes con infecciones bacterianas adquiridas en la comunidad, siendo 40 pacientes con infecciones por bacterias multirresistentes (casos) y 40 pacientes que no presentaron infecciones por bacterias multirresistentes. El instrumento fueron las historias clínicas de los pacientes que cumplían los criterios. Los datos fueron recopilados en el programa Excel versión 2013 y el procesamiento y análisis de datos se hicieron en SPSS versión 28, además se usaron modelos de regresión logística binaria. Obteniendo como resultados: el nivel socioeconómico, la actividad laboral y el tipo de comunidad pr...

Objetivos: Determinar si los B2 agonistas se asocian a mortalidad a los 28 días en pacientes con SARS-CoV-2 en ventilación mecánica Métodos: estudio de cohorte prospectivo. Resultados: Se pudo observar que el uso de B2 agonistas tuvo un efecto protectivo (HR=0,11 IC 95% 0,03-0,37), llegando a reducir la mortalidad en un 89% en los pacientes con SARS-CoV-2 en ventilación mecánica. Las variables predictoras de mortalidad fueron el no uso de B2 de agonistas representó un factor de riesgo de mortalidad y el PaO2/FiO2 un factor protector. En el análisis de supervivencia de Kaplan Meier el tiempo estimado de sobrevida de los pacientes que recibieron B2 agonistas fue mayor en comparación de los pacientes que no recibieron B2 agonistas. Se encontró una diferencia marcada en la mejoría clínica a favor del uso de B2 agonistas. Conclusiones: Existió una reducción de la mortalidad en p...

Introduction: The aim of the study is based on determine whether the use of empirical antibiotic therapy increases the risk of death in adult patients older than 18 years hospitalized with COVID-19. Material and Methods: A systematic review and meta-analysis were performed, taking into account retrospective and prospective studies. The electronic databases Medline/PubMed, Embase, LILACS, and CINAHL were used for the systematic search in the period from December 2019 to May 2021. Odds Ratio and 95% confidence intervals were calculated using the random effect, depending on whether or not heterogeneity exists, the Funnel Plot graph was elaborated to assess the risk of bias. Results: 528 articles were located, which met the inclusion and exclusion criteria, and the eligibility of the full texts of 90 studies was evaluated, resulting in 10 articles. The Odds Ratio of the 10 studies is 1.55 (1...

La presente investigación tuvo como objetivo comparar el efecto del Remifentanilo frente al del Fentanilo en la disminución de la concentración sérica de lactato deshidrogenasa en sangre periférica de Rattus norvegicus albinus anestesiadas con sevorane. Para lo cual se usaron 20 Ratas norvegicus albinus, Sevorane, ampolla de  Fentanilo, Remifentanilo; y para su análisis se empleó el método enzimático. Para el análisis estadístico se  calculó los promedios y errores estándar. Se empleó la prueba de comparación de medias utilizando la distribución de t de student., El fentanilo es un fármaco derivado de los opiáceos de solubilidad lipídica alta, inicio de acción rápida, y duración de acción corta, retirándose de la sangre por metabolismo hepático. El remifentanilo es un agonista de los receptores µ opioides, de duración de acción más corta que el fentanilo po...

La presente investigación tuvo como objetivo comparar el efecto del Remifentanilo frente al del Fentanilo en la disminución de la concentración sérica de lactato deshidrogenasa en sangre periférica de Rattus norvegicus albinus anestesiadas con sevorane. Para lo cual se usaron 20 Ratas norvegicus albinus, Sevorane, ampolla de  Fentanilo, Remifentanilo; y para su análisis se empleó el método enzimático. Para el análisis estadístico se  calculó los promedios y errores estándar. Se empleó la prueba de comparación de medias utilizando la distribución de t de student., El fentanilo es un fármaco derivado de los opiáceos de solubilidad lipídica alta, inicio de acción rápida, y duración de acción corta, retirándose de la sangre por metabolismo hepático. El remifentanilo es un agonista de los receptores µ opioides, de duración de acción más corta que el fentanilo po...

The present investigation was a cross - sectional and retrospective study, with the objective of relating ethanol serum levels to the types of traffic accidents that occurred in the Libertad region during 2014, where 981 samples of blood corresponding to equals Number of individuals. It was found that the type of accident with the highest percentage is 78.28% was the shock, and the lowest percentage is 4.20% of abuse. It is also observed that the highest percentage of these drivers (72.47%), its concentration is 0.5 to 1.5 g / l, where it is included drunken state, where the possibility of traffic accidents caused by drivers is greatly increased, Due to the diminution of the reflexes and difficulty in the visual adaptation and especially in the dark. Then follows the drivers in absolute drunken state (16.53%) whose concentration in blood 1.5 to 2.5 g / ...

The purpose of the present investigation was to determine the effect of X-rays on the mucosa Gastric cancer in Rattus Rattus var. Albinus with a diet enhanced with Triticum Aestivum (wheat) ". Twenty-four adult male albino rats weighing between 200 and 250 g were used, which were randomly distributed into two groups: control and experimental, with 12 animals each. The control group was subdivided randomly into 2 subgroups, the D: which did not receive wheat and was not irradiated, and the B: which did not receive wheat but was irradiated. The Experimental group was subdivided randomly into 2 subgroups, the C: which received wheat and was not irradiated and the A: which received wheat and if it was irradiated. Oral administration of wheat was performed during 16 days prior to X-ray irradiation, 18 mSv, the animals were housed in cages, anesthetized ...

The present investigation was a cross - sectional and retrospective study, with the objective of relating ethanol serum levels to the types of traffic accidents that occurred in the Libertad region during 2014, where 981 samples of blood corresponding to equals Number of individuals. It was found that the type of accident with the highest percentage is 78.28% was the shock, and the lowest percentage is 4.20% of abuse. It is also observed that the highest percentage of these drivers (72.47%), its concentration is 0.5 to 1.5 g / l, where it is included drunken state, where the possibility of traffic accidents caused by drivers is greatly increased, Due to the diminution of the reflexes and difficulty in the visual adaptation and especially in the dark. Then follows the drivers in absolute drunken state (16.53%) whose concentration in blood 1.5 to 2.5 g / l. The drivers have a lot of aggres...

The purpose of the present investigation was to determine the effect of X-rays on the mucosa Gastric cancer in Rattus Rattus var. Albinus with a diet enhanced with Triticum Aestivum (wheat) ". Twenty-four adult male albino rats weighing between 200 and 250 g were used, which were randomly distributed into two groups: control and experimental, with 12 animals each. The control group was subdivided randomly into 2 subgroups, the D: which did not receive wheat and was not irradiated, and the B: which did not receive wheat but was irradiated. The Experimental group was subdivided randomly into 2 subgroups, the C: which received wheat and was not irradiated and the A: which received wheat and if it was irradiated. Oral administration of wheat was performed during 16 days prior to X-ray irradiation, 18 mSv, the animals were housed in cages, anesthetized with 0.6% pentobarbital in doses of 0.5 ...

Objective: To determine the frequency of multiresistant bacteria Carriers (BM) and its profile of resistance in critical areas (ICU-INCU) in a public hospital in northern Peru (HRL). Material and methods: A cross-sectional observational study was conducted during February to May 2015, in 48 patients and 32 healthcare staff. 4 anatomical regions for sampling were considered and supplemented instruments with antibiotics were used for primary isolation of BM. The resistance phenotype was confirmed by Jailer's test, Modified Hodge and susceptibility to cefoxitin. Results: The frequencies of BM in patients and healthcare staff were 79.1% and 3.1% respectively; also 89.5% of patients were already carriers at the time of admission mainly from Emergency Service, being anorectal region the principal source of isolates with 75.0%. It also was determined that production of extended spectrum beta-la...

During the COVID-19 pandemic, the increase in reports of human monkeypox virus infection cases spreading in many countries outside Africa is a major cause for concern. Therefore, this study aimed to explore the evidence of antiviral pharmacotherapy available for the treatment of adult patients with monkeypox. A scoping review of the literature was conducted using PubMed, Scopus, Web of Science, Embase, and CENTRAL databases until 12 September 2022. The key search terms used were “monkeypox” and “treatment”. A total of 1927 articles were retrieved using the search strategy. After removing duplicates (n = 1007) and examining by title, abstract, and full text, 11 studies reporting case reports of monkeypox with antiviral treatment were included, detailing the number of monkeypox cases, clinical manifestations, number of participants with antiviral treatment, history of sexually tran...

During the COVID-19 pandemic, the increase in reports of human monkeypox virus infection cases spreading in many countries outside Africa is a major cause for concern. Therefore, this study aimed to explore the evidence of antiviral pharmacotherapy available for the treatment of adult patients with monkeypox. A scoping review of the literature was conducted using PubMed, Scopus, Web of Science, Embase, and CENTRAL databases until 12 September 2022. The key search terms used were “monkeypox” and “treatment”. A total of 1927 articles were retrieved using the search strategy. After removing duplicates (n = 1007) and examining by title, abstract, and full text, 11 studies reporting case reports of monkeypox with antiviral treatment were included, detailing the number of monkeypox cases, clinical manifestations, number of participants with antiviral treatment, history of sexually tran...

uring the COVID-19 pandemic, the increase in reports of human monkeypox virus infection cases spreading in many countries outside Africa is a major cause for concern. Therefore, this study aimed to explore the evidence of antiviral pharmacotherapy available for the treatment of adult patients with monkeypox. A scoping review of the literature was conducted using PubMed, Scopus, Web of Science, Embase, and CENTRAL databases until 12 September 2022. The key search terms used were “monkeypox” and “treatment”. A total of 1927 articles were retrieved using the search strategy. After removing duplicates (n = 1007) and examining by title, abstract, and full text, 11 studies reporting case reports of monkeypox with antiviral treatment were included, detailing the number of monkeypox cases, clinical manifestations, number of participants with antiviral treatment, history of sexually trans...