En los últimos cinco años, la malaria se ha incrementado de forma constante en la Amazonía Peruana. Este estudio busca determinar la heterogeneidad micro-geográfica de las parasitemias por Plasmodium vivax en comunidades rurales de la Amazonía Peruana. Cuatro encuestas transversales de detección activa de casos (DAC) fueron realizadas entre Mayo y Julio del 2015 en cuatro comunidades rurales del distrito de Mazán. La detección de agrupaciones (clústers) de parasitemias por P. vivax dentro de las comunidades fue determinada mediante el análisis de Anselin’s Local Moran’s I (LISA) y se utilizaron modelos de regresión de Poisson multinivel para evaluar si los factores asociados con parasitemias por P. vivax varían a un nivel micro-geográfico, con dos aproximaciones: 1) incluyendo todas las comunidades y términos de interacción (multi-comunidad) y 2) un modelo por cada com...

The incidence of malaria due both to Plasmodium falciparum and Plasmodium vivax in the Peruvian Amazon has risen in the past 5 years. This study tested the hypothesis that the maintenance and emergence of malaria in hypoendemic regions such as Amazonia is determined by submicroscopic and asymptomatic Plasmodium parasitaemia carriers. The present study aimed to precisely quantify the rate of very-low parasitaemia carriers in two sites of the Peruvian Amazon in relation to transmission patterns of P.vivax and P.falciparum in this area. Methods: This study was carried out within the Amazonian-ICEMR longitudinal cohort. Blood samples were collected for light microscopy diagnosis and packed red blood cell (PRBC) samples were analysed by qPCR. Plasma samples were tested for total IgG reactivity against recombinant PvMSP-10 and PfMSP-10 antigens by ELISA. Occupation and age 10 years and greater...

Plasmodium vivax is the main cause of malaria in the Peruvian Amazon and Mazan is considered one of its districts with high risk of malaria transmission. In this site, previous studies has described P. vivax transmission as heterogenic and has suggested that its prevalence is influenced by factors linked to human mobilization. However, the contribution of this factor have not been assessed yet. Population genetic tools provide information on the individual contribution of the factors that favor the transmission and evaluate the demographic patterns of dispersion of the parasite populations which are influenced by the human mobilization. In order to evaluate contribution of human mobilization to malariatransmission in Mazan, in this work we use a Bayesian framework to identify genetic sub-populations in each basin and to discriminate between endogenous and imported cases. Socio-demographi...