Effects of climate change have led to a reduction in precipitation and an increase in temperature across several areas of the world. This has resulted in a sharp decline of glaciers and an increase in surface runoff in watersheds due to snowmelt. This situation requires a better understanding to improve the management of water resources in settled areas downstream of glaciers. In this study, the snowmelt runoff model (SRM) was applied in combination with snow-covered area information (SCA), precipitation, and temperature climatic data to model snowmelt runoff in the Santa River sub-basin (Peru). The procedure consisted of calibrating and validating the SRM model for 2005–2009 using the SRTM digital elevation model (DEM), observed temperature, precipitation and SAC data. Then, the SRM was applied to project future runoff in the sub-basin under the climate change scenarios RCP 4.5 and RC...