1
revisión
Publicado 2022
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Advances in molecular diagnostics have led to improved stratification and targeted interventions in the treatment of children with brain tumors. This has necessitated complex infrastructure to deliver all the required testing in a clinically useful time period. However, in less-resourced countries, this testing is not routinely available and an ever-widening gap in the ability to deliver more tailored therapies including targeted agents is increasingly evident. This article reviews the recent advances and suggests practical ways of ensuring that genomic advances are applied according to available resources.
2
artículo
Publicado 2020
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This study aims to know how the training processes of practicing teachers contribute to the construction of beliefs about teaching at the university. Froma qualitative methodology with agrounded theory approach, professors from public and private universities were selected through theoretical sampling. In-depth interviews were conducted to collect data whichwere analytically coded. Among the results it was found that the teachers' beliefs come frominstitutional training of a normative typewhich emphasizes a functional teaching in didactic techniques, use of technology and innovation, excluding training in knowledge of the discipline they teach. Thus,it was also found that teachers carry out self-training processes on a personal initiativefor updating scientific knowledgeand develop their practices teaching with strategies that they themselves use to learn, because they believe in their o...
3
artículo
Publicado 2020
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Este estudio se propuso conocer cómo contribuyen los procesos formativos de profesores en ejercicio, en la construcción de creencias acerca de la enseñanza en la universidad. Con base en la metodología cualitativa y enfoque de teoría fundamentada se seleccionaron profesores de universidades públicas y privadas, mediante el muestreo teórico. Se realizaron entrevistas a profundidad para colectar datos y se codificaron analíticamente. Entre los resultados destacan las creencias que provienen de la capacitación institucional de tipo normativa, la cual enfatiza una enseñanza funcional, en técnicas didácticas, uso de tecnología e innovación, excluyendo la capacitación en el conocimiento de la disciplina que enseñan. Así también se encontró que los profesores llevan a cabo por iniciativa personal procesos de autoformación, para la actualización en conocimientos científicos...
4
artículo
Publicado 1997
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Compares the possibilities of New Zealand and Peru in export agriculture and agribusiness, in which both countries have great potential. He considers that, to remain competitive internationally, both countries must stop exporting raw materials and replace them with products with higher added value. It analyzes the situation and the expected evolution of four New Zealand export products: meat, milk and derivatives, venison and kiwi, and argues that the central aspect to take advantage of the challenges and opportunities in agribusiness is to never forget the importance of the consumer and the consumption patterns, as the importance given to products sensitive to the environment is growing. As possible strategies, mention is made of taking advantage of the comparative advantages offered by nature, developing products specifically destined for the export market, protecting natural resources...
5
artículo
Publicado 2019
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The impact of rococo has been traditionally overlooked in the retablos of Peru. Although scholars recognized that rococo appeared on certain retablos of late-18th century Lima and Trujillo as decoration, little effort has been made to investigate how the style reached the viceroyalty. This article identifies printed sources from France and Germany (Augsburg) and considers how artists used them. It also compares the treatment of rococo motifs and forms in Trujillo with the way those forms are treated in the Cono Sur (present-day Argentina and Chile). Although the same sources were used in both areas, the retablos of the Cono Sur were frequently made by immigrants (especially from German-speaking lands) while those in the north were usually made by criollo craftsmen.
6
artículo
Publicado 2025
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The architectural sculpture of the so-called ‘Mestizo Baroque’ or ‘Andean Hybrid Baroque’ churches of southern Peru and Bolivia has fascinated – and polarized – scholars of Latin American colonial art for precisely a century, particularly the degree to which it reflects indigenous sensibilities and styles. Scholars from Ángel Guido and Martín Noel to Teresa Gisbert and the present reviewer have paid particular attention to the significance of the rich assortment of flowers, other plants, birds, and animals that animate these facades, some of them originating in European Christian iconography and others clearly of Andean and Amazonian origin.
7
artículo
Publicado 1997
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Compare the possibilities of New Zealand and Peru in export agriculture and agribusiness, in which both countries have great potential. He considers that, to remain competitive internationally, both countries must stop exporting raw materials and replace them with products with higher added value. It analyzes the situation and the expected evolution of four New Zealand export products: meat, milk and derivatives, venison and kiwi, and argues that the central aspect to take advantage of the challenges and opportunities in agribusiness is to never forget the importance of the consumer and the consumption patterns, as the importance given to products sensitive to the environment is growing. As possible strategies, mention is made of taking advantage of the comparative advantages offered by nature, developing products specifically destined for the export market, protecting natural resources ...
8
artículo
Publicado 2022
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Peripheral T-cell lymphomas (PTCL) are agressive lymphomas engineered mouse models and spontaneous PTCL models were that develop from mature T cells. The most common PTCLs are used to functionally examine the role of Notch signaling, and genetically, molecularly, and clinically diverse and are generally Notch1/Notch2 blockade and pan-Notch blockade using domiassociated with dismal outcomes. While Notch signaling plays a nant-negative MAML significantly impaired the proliferation of critically important role in both the development of immature T malignant T cells and PTCL progression in these models. Treatment cells and their malignant transformation, its role in PTCL is poorly with DLL1/DLL4 blocking antibodies established that Notch sigunderstood, despite the increasingly appreciated function of Notch naling is ligand-dependent. Together, these findings reveal a role for in regulating t...
9
artículo
Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets account for a minority of lymphoproliferative neoplasms. These T-cell derived neoplasms, while molecularly and genetically heterogeneous, exploit transcription factors and signaling pathways that are critically important in normal T-cell biology, including those implicated in antigen-, costimulatory-, and cytokine-receptor signaling. The transcription factor GATA-3 regulates the growth and proliferation of both immature and mature T cells and has recently been implicated in T-cell neoplasms, including the most common mature T-cell lymphoma observed in much of the Western world. Here we show that GATA-3 is a proto-oncogene across the spectrum of T-cell neoplasms, including those derived from T-cell progenitors and their mature progeny, and further define the transcriptional programs that are GATA-3 ...
