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Publicado 2017
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This work was supported by the São Paulo Research Foundation (FAPESP, Brazil) [grant numbers 2014/16998-3 (project), 2014/26433-3 (JC Pereira B.Sc. scholarship)]; the National Council for Scientific and Technological Development (CNPq, Brazil) [grant number 401004/2014-7 (project) and B Miatelo B.Sc. scholarship (PIBIC)]; and the “Consejo Nacional de Ciencia, Tecnología e Inovación Tecnológica” (CONCYTEC, Perú) [grant number 272-2015-FONDECYT (A.C. Miano Ph.D. scholarship)].
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Consejo Nacional de Ciencia, Tecnología e Inovación Tecnológica (CONCYTEC, Peru) . Grant Number: 272-2015-FONDECY
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Publicado 2016
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The authors are grateful to the São Paulo Research Foundation (FAPESP, Brazil) for funding the project no. 2014/16998-3 and JC Pereira B.Sc. scholarship (2014/26433-3); the National Council for Scientific and Technological Development (CNPq, Brazil) for funding the project no. 401004/2014-7 and MD Matta Jr. post-doctoral fellowship (158545/2015-0); Cienciactiva for the A.C. Miano Ph.D. scholarship, from the “Consejo Nacional de Ciencia, Tecnología e Inovación Tecnológica” (CONCYTEC, Peru; Contract 272-2015-FONDECYT) and Coordination for the Improvement of Higher Education Personnel (CAPES, Brazil) for the N Castanha M.Sc. scholarship. The authors are also grateful to the “Núcleo de Apoio à Pesquisa em Microscopia Eletrônica Aplicada à Pesquisa Agropecuária” (NAP/MEPA-ESALQ/USP) for the support and facilities of Electronic Microscopy. By describing an important process fo...
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Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets account for a minority of lymphoproliferative neoplasms. These T-cell derived neoplasms, while molecularly and genetically heterogeneous, exploit transcription factors and signaling pathways that are critically important in normal T-cell biology, including those implicated in antigen-, costimulatory-, and cytokine-receptor signaling. The transcription factor GATA-3 regulates the growth and proliferation of both immature and mature T cells and has recently been implicated in T-cell neoplasms, including the most common mature T-cell lymphoma observed in much of the Western world. Here we show that GATA-3 is a proto-oncogene across the spectrum of T-cell neoplasms, including those derived from T-cell progenitors and their mature progeny, and further define the transcriptional programs that are GATA-3 ...