Resultados de Búsqueda por Autor

1

artículo

Notch Signaling Promotes Mature T-Cell Lymphomagenesis

Publicado por
Gao, X, Wang, C, Abdelrahman, S, Kady, N, Murga-Zamalloa, C, Gann, P, Sverdlov, M, Wolfe, A, Polk, A, Brown, N, Bailey, N, Inamdar, K, Casavilca-Zambrano, S, Montes Gil, J, Barrionuevo, C, Taxa-Rojas, L, Reneau, J, Siebe, CW, Maillard, I, Wilcox, RA

Publicado 2022

Enlace

Peripheral T-cell lymphomas (PTCL) are agressive lymphomas engineered mouse models and spontaneous PTCL models were that develop from mature T cells. The most common PTCLs are used to functionally examine the role of Notch signaling, and genetically, molecularly, and clinically diverse and are generally Notch1/Notch2 blockade and pan-Notch blockade using domiassociated with dismal outcomes. While Notch signaling plays a nant-negative MAML significantly impaired the proliferation of critically important role in both the development of immature T malignant T cells and PTCL progression in these models. Treatment cells and their malignant transformation, its role in PTCL is poorly with DLL1/DLL4 blocking antibodies established that Notch sigunderstood, despite the increasingly appreciated function of Notch naling is ligand-dependent. Together, these findings reveal a role for in regulating t...

2

artículo

GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms

Publicado por
Geng, X, Wang, C, Gao, X, Chowdhury, P, Weiss, J, Villegas, JA, Saed, B, Perera, T, Hu, Y, Reneau, J, Sverdlov, M, Wolfe, A, Brown, N, Harms, P, Bailey, NG, Inamdar K, Hristov, AC, Tejasvi, T, Montes, J, Barrionuevo, C, Taxa-rojas, L, Casavilca-Sambrano, S, de Pádua Covas Lage JLA, Culler HF, Pereira, J, Runge, JS, Qin, T, Tsoi, LC, Hong, HS, Zhang L, Lyssiotis, CA, Ohe, R, Toubai, T, Zevallos-Morales, A, Murga-Zamalloa, C, Wilcox, RA

Publicado 2022

Enlace

Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets account for a minority of lymphoproliferative neoplasms. These T-cell derived neoplasms, while molecularly and genetically heterogeneous, exploit transcription factors and signaling pathways that are critically important in normal T-cell biology, including those implicated in antigen-, costimulatory-, and cytokine-receptor signaling. The transcription factor GATA-3 regulates the growth and proliferation of both immature and mature T cells and has recently been implicated in T-cell neoplasms, including the most common mature T-cell lymphoma observed in much of the Western world. Here we show that GATA-3 is a proto-oncogene across the spectrum of T-cell neoplasms, including those derived from T-cell progenitors and their mature progeny, and further define the transcriptional programs that are GATA-3 ...

3

artículo

Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery

Publicado por
Devereaux, P. J., Biccard, Bruce M., Sigamani, Alben, Xavier, Denis, Chan, Matthew T. V., Srinathan, Sadeesh K., Walsh, Michael, Abraham, Valsa, Pearse, Rupert, Wang, C. Y., Sessler, Daniel I., Kurz, Andrea, Szczeklik, Wojciech, Berwanger, Otavio, Villar, Juan Carlos, Málaga Rodríguez, Germán Javier, Garg, Amit X., Chow, Clara K., Ackland, Gareth, Patel, Ameen, Borges, Flavia Kessler, Belley-Cote, Emilie P., Duceppe, Emmanuelle, Spence, Jessica, Tandon, Vikas, Williams, Colin, Sapsford, Robert J., Polanczyk, Carisi A., Tiboni, Maria, Alonso-Coello, Pablo, Faruqui, Atiya, Heels-Ansdell, Diane, Lamy, Andre, Whitlock, Richard, LeManach, Yannick, Roshanov, Pavel S., McGillion, Michael, Kavsak, Peter, McQueen, Matthew J., Thabane, Lehana, Rodseth, Reitze N., Buse, Giovanna A. Lurati, Bhandari, Mohit, Garutti, Ignacia, Jacka, Michael J., Schunemann, Holger J., Cortes, Olga Lucia, Coriat, Pierre, Dvirnik, Nazari, Botto, Fernando, Pettit, Shirley, Jaffe, Allan S., Guyatt, Gordon H.

Publicado 2017

Enlace

Importance: Little is known about the relationship between perioperative high-sensitivity troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac surgery (MINS). Objective: To determine the association between perioperative hsTnT measurements and 30-day mortality and potential diagnostic criteria for MINS (ie, myocardial injury due to ischemia associated with 30-day mortality). Design, Setting, and Participants: Prospective cohort study of patients aged 45 years or older who underwent inpatient noncardiac surgery and had a postoperative hsTnT measurement. Starting in October 2008, participants were recruited at 23 centers in 13 countries; follow-up finished in December 2013. Exposures: Patients had hsTnT measurements 6 to 12 hours after surgery and daily for 3 days; 40.4% had a preoperative hsTnT measurement. Main Outcomes and Measures: A modified Mazu...