Background: Currently, gastric cancer (GC) is considered a public health problem worldwide. Using medicinal plants for the prevention of chronic diseases such as cancer constitutes new alternatives in traditional medicine. Oenothera rosea (OR) could be an option, but it needs to be evaluated. Aim: The main objective of this study was to evaluate the protective effect of OR extract on N-methyl-N-nitrosourea (NMU)-induced GC in rats. Methods: In total, 80 male Holtzman rats were randomized into five groups. Group A received the saline solution (5mL/kg), group B received NMU 500 μg/kg (cancer inductor) by oral administration for 16 weeks, and groups C, D, and E were treated with OR extract (100, 200, and 300 mg/kg, respectively) and NMU in order to evaluate the preventive effect on cancer induced by NMU for 16 weeks. Blood and histological samples of stomachs were collected to determine hi...

Objectives: To determine the cicatrizing effect of Copaifera officinalis’ stem bark copaiba oil compared with omeprazole 20 mg in patients with diagnosis of peptic ulcer. Design: Experimental, comparative, phase II, randomized, double-blind, parallel-group clinical trial. Setting: Clinical Investigation Institute, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Participants: Patients with diagnosis of peptic ulcer. Interventions: Clinical diagnosis of peptic ulcer was done by endoscopy as well as pre and post treatment evaluation following administration of copaiba oil formulated capsules (80 mg and 120 mg). Sixty patients enrolled voluntarily to the study and signed informed consent as approved by the Institutional Review Board. Patients were randomly distributed in three groups of 20 cases each according to arrival order; the first and second group received...

La investigación tuvo como objetivo evaluar la eficacia y seguridad de supositorios de aceite de Copaifera officinalis L. “copaiba” en pacientes con diagnóstico definitivo de crisis hemorroidal aguda. El ensayo fue clínico prospectivo, controlado, comparativo, aleatorio y se realizó en el Instituto de Investigaciones Clínicas de la Facultad de Medicina de UNMSM. y Servicio de Gastroenterología del Hospital Nacional Dos de Mayo. Los pacientes evaluados presentaban diagnóstico definitivo de crisis hemorroidal aguda. El diagnóstico se realizó mediante estudio clínico y proctoscópico antes y después del tratamiento, además de exámenes auxiliares serológicos; 60 pacientes fueron enrolados voluntariamente al protocolo cumpliendo con los criterios éticos de investigación; los cuales fueron distribuidos en 3 grupos de 20 casos cada uno, administrándoseles supositorios de co...