Clinical characteristics and molecular detection of in hospitalized children with a clinical diagnosis of whooping cough in Peru.
Descripción del Articulo
Pertussis is an infectious disease caused by the Gram-negative bacterium Bordetella pertussis. In Peru, actual public health programs indicate that vaccination against B. pertussis must be mandatory and generalized, besides all detected cases must be reported. The objective of this study was to dete...
| Autores: | , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2021 |
| Institución: | Universidad Peruana de Ciencias Aplicadas |
| Repositorio: | UPC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorioacademico.upc.edu.pe:10757/655868 |
| Enlace del recurso: | http://hdl.handle.net/10757/655868 |
| Nivel de acceso: | acceso abierto |
| Materia: | Bordetella pertussis Peru Real-time polymerase chain reaction Whooping cough |
| id |
UUPC_f8e1fcb858c3c26ad57f39e1738a125e |
|---|---|
| oai_identifier_str |
oai:repositorioacademico.upc.edu.pe:10757/655868 |
| network_acronym_str |
UUPC |
| network_name_str |
UPC-Institucional |
| repository_id_str |
2670 |
| dc.title.en_US.fl_str_mv |
Clinical characteristics and molecular detection of in hospitalized children with a clinical diagnosis of whooping cough in Peru. |
| title |
Clinical characteristics and molecular detection of in hospitalized children with a clinical diagnosis of whooping cough in Peru. |
| spellingShingle |
Clinical characteristics and molecular detection of in hospitalized children with a clinical diagnosis of whooping cough in Peru. Del Valle-Mendoza, Juana Bordetella pertussis Peru Real-time polymerase chain reaction Whooping cough |
| title_short |
Clinical characteristics and molecular detection of in hospitalized children with a clinical diagnosis of whooping cough in Peru. |
| title_full |
Clinical characteristics and molecular detection of in hospitalized children with a clinical diagnosis of whooping cough in Peru. |
| title_fullStr |
Clinical characteristics and molecular detection of in hospitalized children with a clinical diagnosis of whooping cough in Peru. |
| title_full_unstemmed |
Clinical characteristics and molecular detection of in hospitalized children with a clinical diagnosis of whooping cough in Peru. |
| title_sort |
Clinical characteristics and molecular detection of in hospitalized children with a clinical diagnosis of whooping cough in Peru. |
| author |
Del Valle-Mendoza, Juana |
| author_facet |
Del Valle-Mendoza, Juana del Valle-Vargas, Cristina Aquino-Ortega, Ronald Del Valle, Luis J Cieza-Mora, Erico Silva-Caso, Wilmer Bazán-Mayra, Jorge Zavaleta-Gavidia, Victor Aguilar-Luis, Miguel Angel Cornejo-Pacherres, Hernán Martins-Luna, Johanna Cornejo-Tapia, Angela |
| author_role |
author |
| author2 |
del Valle-Vargas, Cristina Aquino-Ortega, Ronald Del Valle, Luis J Cieza-Mora, Erico Silva-Caso, Wilmer Bazán-Mayra, Jorge Zavaleta-Gavidia, Victor Aguilar-Luis, Miguel Angel Cornejo-Pacherres, Hernán Martins-Luna, Johanna Cornejo-Tapia, Angela |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Del Valle-Mendoza, Juana del Valle-Vargas, Cristina Aquino-Ortega, Ronald Del Valle, Luis J Cieza-Mora, Erico Silva-Caso, Wilmer Bazán-Mayra, Jorge Zavaleta-Gavidia, Victor Aguilar-Luis, Miguel Angel Cornejo-Pacherres, Hernán Martins-Luna, Johanna Cornejo-Tapia, Angela |
| dc.subject.en_US.fl_str_mv |
Bordetella pertussis Peru Real-time polymerase chain reaction Whooping cough |
| topic |
Bordetella pertussis Peru Real-time polymerase chain reaction Whooping cough |
| description |
Pertussis is an infectious disease caused by the Gram-negative bacterium Bordetella pertussis. In Peru, actual public health programs indicate that vaccination against B. pertussis must be mandatory and generalized, besides all detected cases must be reported. The objective of this study was to determine the prevalence of B. pertussis among children under five years of age with a presumptive diagnosis of whopping cough in Cajamarca, a region located in northern Peru. |
| publishDate |
2021 |
| dc.date.accessioned.none.fl_str_mv |
2021-05-06T20:58:59Z |
| dc.date.available.none.fl_str_mv |
2021-05-06T20:58:59Z |
| dc.date.issued.fl_str_mv |
2021-01 |
| dc.type.en_US.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.issn.none.fl_str_mv |
2008-3289 |
| dc.identifier.pmid.none.fl_str_mv |
33889359 |
| dc.identifier.doi.none.fl_str_mv |
10.18502/ijm.v13i1.5488 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10757/655868 |
| dc.identifier.journal.en_US.fl_str_mv |
Iranian journal of microbiology |
| dc.identifier.isni.none.fl_str_mv |
0000 0001 2196 144X |
| identifier_str_mv |
2008-3289 33889359 10.18502/ijm.v13i1.5488 Iranian journal of microbiology 0000 0001 2196 144X |
| url |
http://hdl.handle.net/10757/655868 |
| dc.language.iso.en_US.fl_str_mv |
eng |
| language |
eng |
| dc.relation.url.en_US.fl_str_mv |
https://pubmed.ncbi.nlm.nih.gov/33889359/ |
| dc.rights.en_US.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.*.fl_str_mv |
Attribution-NonCommercial-ShareAlike 4.0 International |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ |
| dc.format.en_US.fl_str_mv |
application/pdf |
| dc.publisher.en_US.fl_str_mv |
Tehran University of Medical Sciences |
| dc.source.es_PE.fl_str_mv |
Universidad Peruana de Ciencias Aplicadas (UPC) Repositorio Academico - UPC |
| dc.source.none.fl_str_mv |
reponame:UPC-Institucional instname:Universidad Peruana de Ciencias Aplicadas instacron:UPC |
| instname_str |
Universidad Peruana de Ciencias Aplicadas |
| instacron_str |
UPC |
| institution |
UPC |
| reponame_str |
UPC-Institucional |
| collection |
UPC-Institucional |
| dc.source.journaltitle.none.fl_str_mv |
Iranian journal of microbiology |
| dc.source.volume.none.fl_str_mv |
13 |
| dc.source.issue.none.fl_str_mv |
1 |
| dc.source.beginpage.none.fl_str_mv |
23 |
| dc.source.endpage.none.fl_str_mv |
30 |
| dc.source.country.none.fl_str_mv |
Iran |
| bitstream.url.fl_str_mv |
https://repositorioacademico.upc.edu.pe/bitstream/10757/655868/5/IJM-13-23.pdf.jpg https://repositorioacademico.upc.edu.pe/bitstream/10757/655868/4/IJM-13-23.pdf.txt https://repositorioacademico.upc.edu.pe/bitstream/10757/655868/3/license.txt https://repositorioacademico.upc.edu.pe/bitstream/10757/655868/2/license_rdf https://repositorioacademico.upc.edu.pe/bitstream/10757/655868/1/IJM-13-23.pdf |
| bitstream.checksum.fl_str_mv |
d4b2046948c3e9ecf0f20a36009dc690 66b1d4d3c5ab89edd32ff73239943962 8a4605be74aa9ea9d79846c1fba20a33 934f4ca17e109e0a05eaeaba504d7ce4 beb2fe01f9f67e2439e2d11c473c7837 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio académico upc |
| repository.mail.fl_str_mv |
upc@openrepository.com |
| _version_ |
1837188349450780672 |
| spelling |
72c40e99cf9b824e2bde963be2425b9b6edcb3c7c7224757af6b165aab0ee8fd5001eded142e2aa7698242b38e7b62bbc730083e4b4b4fdf6cb27d0af2ebfdfc72ff6e2f71b982532605c08ec787504e734c91570ccc20664e384fad118e0923d7b4dc10c47b6bffc947a57e30ebd3c04b0062ce6043cb4c2dacaa378b39530255b5009432e54b65fd730068d6cc43a4e22ec4f333488cef35a963efa611789ef03e88500cb0dcd195d62aa4a0afba96aa46e42d350031b658ac809296b89763c7daf423d8d8500Del Valle-Mendoza, Juanadel Valle-Vargas, CristinaAquino-Ortega, RonaldDel Valle, Luis JCieza-Mora, EricoSilva-Caso, WilmerBazán-Mayra, JorgeZavaleta-Gavidia, VictorAguilar-Luis, Miguel AngelCornejo-Pacherres, HernánMartins-Luna, JohannaCornejo-Tapia, Angela2021-05-06T20:58:59Z2021-05-06T20:58:59Z2021-012008-32893388935910.18502/ijm.v13i1.5488http://hdl.handle.net/10757/655868Iranian journal of microbiology0000 0001 2196 144XPertussis is an infectious disease caused by the Gram-negative bacterium Bordetella pertussis. In Peru, actual public health programs indicate that vaccination against B. pertussis must be mandatory and generalized, besides all detected cases must be reported. The objective of this study was to determine the prevalence of B. pertussis among children under five years of age with a presumptive diagnosis of whopping cough in Cajamarca, a region located in northern Peru.Background and Objectives: Pertussis is an infectious disease caused by the Gram-negative bacterium Bordetella pertussis. In Peru, actual public health programs indicate that vaccination against B. pertussis must be mandatory and generalized, be-sides all detected cases must be reported. The objective of this study was to determine the prevalence of B. pertussis among children under five years of age with a presumptive diagnosis of whopping cough in Cajamarca, a region located in northern Peru. Materials and Methods: The population of this cross-sectional study were children under 5 years old hospitalized as presumptive cases of pertussis during December 2017 to December 2018. The nasopharyngeal samples were analyzed by real-time PCR for the detection of B. pertussis. Results: B. pertussis was identified as PCR + in 42.3% of our sample (33/78). The clinical presentation that was observed most frequently includes paroxysmal coughing (97%), difficulty breathing (69.7%), cyanosis (72.7%) and post-tussive em-esis (60.6%). Additionally, pneumonia was the most observed complication (33.3%). Four of the patients with PCR+ for B. pertussis presented only lymphocytosis, five only leukocytosis, two patients with decreased leukocytosis and lymphocytes and only one patient with leukopenia and relative lymphocytosis. There was a percentage of 84.8% of unvaccinated children in the PCR+ group. Finally, the mother was the most frequent symptom carrier (18.2%). Conclusion: In conclusion, in the studied population there is a high rate of PCR+ cases for B. pertussis. Laboratory values may show leukopenia or lymphopenia in patients with pertussis. It is necessary to use appropriate laboratory diagnostic tests in all infants with respiratory symptoms for B. pertussis. Since, the clinical diagnosis overestimates the diagnosis of pertussis.Revisión por paresapplication/pdfengTehran University of Medical Scienceshttps://pubmed.ncbi.nlm.nih.gov/33889359/info:eu-repo/semantics/openAccessAttribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/Universidad Peruana de Ciencias Aplicadas (UPC)Repositorio Academico - UPCIranian journal of microbiology1312330Iranreponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCBordetella pertussisPeruReal-time polymerase chain reactionWhooping coughClinical characteristics and molecular detection of in hospitalized children with a clinical diagnosis of whooping cough in Peru.info:eu-repo/semantics/article2021-05-06T20:59:00ZTHUMBNAILIJM-13-23.pdf.jpgIJM-13-23.pdf.jpgGenerated Thumbnailimage/jpeg96133https://repositorioacademico.upc.edu.pe/bitstream/10757/655868/5/IJM-13-23.pdf.jpgd4b2046948c3e9ecf0f20a36009dc690MD55falseTEXTIJM-13-23.pdf.txtIJM-13-23.pdf.txtExtracted texttext/plain30570https://repositorioacademico.upc.edu.pe/bitstream/10757/655868/4/IJM-13-23.pdf.txt66b1d4d3c5ab89edd32ff73239943962MD54falseLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorioacademico.upc.edu.pe/bitstream/10757/655868/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD53falseCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81031https://repositorioacademico.upc.edu.pe/bitstream/10757/655868/2/license_rdf934f4ca17e109e0a05eaeaba504d7ce4MD52falseORIGINALIJM-13-23.pdfIJM-13-23.pdfapplication/pdf724393https://repositorioacademico.upc.edu.pe/bitstream/10757/655868/1/IJM-13-23.pdfbeb2fe01f9f67e2439e2d11c473c7837MD51true10757/655868oai:repositorioacademico.upc.edu.pe:10757/6558682021-05-07 03:31:32.091Repositorio académico upcupc@openrepository.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 |
| score |
13.95948 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
