High-risk histopathological features of retinoblastoma following primary enucleation: A Global Study Of 1,426 Patients From 5 Continents

• Autores: Kaliki, S, Vempuluru, VS, Bakal, KR, Dorji, S, Tanna, V, Shields, CN, Fallon, SJ, Raval, V, Ahmad, A, Mushtaq, A, Hussain, M, Yousef, YA, Mohammad, M, Roy, SR, Huque, F, Tatiana, U, Yuri, S, Vladimir, P, Zambrano, SC, Alarcón-León, S, Valdiviezo-Zapata, C, Vargas-Martorellet, M, Gutierrez-Chira, C, Buitrago, M, Ortiz, JS, Diaz-Coronado, R, Tripathy, D, Rath, S, Patil, G, Berry, JL, Pike, S, Brown, B, Tanabe, M, Frenkel, S, Eiger-Moscovich, M, Pe'er, J, Shields, CL, Eagle, RC,, Jr, Laiton, A, Velasco, AM, Vega, K, Desimone, J, Bejjanki, KM, Kapoor, AG, Venkataraman, A, Bryant, V, Reddy, MA, Sagoo, MS, Hubbard, GB, Azarcon, CP, Olson, TA, Grossniklaus, H, Rolfe, O, Staffieri, SE, O'day, R, Mathew, AA, Elder, JE, Mckenzie, JD, Fabian, ID, Shemesh, R, Vishnevskia-Dai, V, Ali, MH, Jakati, S, Mishra, DK, Palkonda, VAR
• Formato: artículo
• Fecha de Publicación: 2024
• Institución: Instituto Nacional de Enfermedades Neoplásicas
• Repositorio: INEN-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.inen.sld.pe:20.500.14703/432
• Enlace del recurso: https://hdl.handle.net/20.500.14703/432
• Nivel de acceso: acceso abierto
• Materia: chemotherapy; enucleation; eye; high-risk features; histopathology; retinoblastoma; tumor; https://purl.org/pe-repo/ocde/ford#3.02.21

Purpose: To evaluate high-risk histopathological features following primary enucleation of eyes with retinoblastoma and assess the patient outcomes across continents. Methods: A retrospective study of 1,426 primarily enucleated retinoblastoma eyes from five continents. Results: Of all, 923 (65%) were from Asia (AS), 27 (2%) from Australia (AUS), 120 (8%) from Europe (EUR), 162 (11%) from North America (NA), and 194 (14%) from South America (SA). Based on the continent (AS vs. AUS vs. EUR vs. NA vs. SA), the histopathological features included massive choroidal invasion (31% vs. 7% vs. 13% vs. 19% vs. 27%, P = 0.001), postlaminar optic nerve invasion (27% vs. 0% vs. 16% vs. 21% vs. 19%, P = 0.0006), scleral infiltration (5% vs. 0% vs. 4% vs. 2% vs. 7%, P = 0.13), and microscopic extrascleral infiltration (4% vs. 0% vs. <1% vs. <1% vs. 4%, P = 0.68). Adjuvant chemotherapy with/without orbital radiotherapy was given to 761 (53%) patients. Based on Kaplan-Meier estimates in different continents (AS vs. AUS vs. EUR vs. NA vs. SA), the 6-year risk of orbital tumor recurrence was 5% versus 2% versus 0% versus 0% versus 12% (P < 0.001), systemic metastasis was reported in 8% versus 5% versus 2% versus 0% versus 13% (P = 0.001), and death in 10% versus 3% versus 2% versus 0% versus 11% (P < 0.001) patients. Conclusion: There is a wide variation in the infiltrative histopathological features of retinoblastoma across continents, resulting in variable outcomes. SA and AS had a higher risk of orbital tumor recurrence, systemic metastasis, and death compared to AUS, EUR, and NA. Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.