Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies
Descripción del Articulo
Aim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and clinicopathological features in different malignancies. Methods: 209 pathological samples fro...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2019 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/2743 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/2743 https://doi.org/10.2217/bmm-2019-0178 |
| Nivel de acceso: | acceso abierto |
| Materia: | melanoma biomarker cancer cervix density gastric glioblastoma lung lymphocytes macrophages http://purl.org/pe-repo/ocde/ford#1.06.01 |
| id |
CONC_476a5dcb730c73f3c0341d49d0f853b9 |
|---|---|
| oai_identifier_str |
oai:repositorio.concytec.gob.pe:20.500.12390/2743 |
| network_acronym_str |
CONC |
| network_name_str |
CONCYTEC-Institucional |
| repository_id_str |
4689 |
| dc.title.none.fl_str_mv |
Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies |
| title |
Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies |
| spellingShingle |
Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies Castaneda C.A. melanoma biomarker cancer cervix density gastric glioblastoma lung lymphocytes macrophages http://purl.org/pe-repo/ocde/ford#1.06.01 |
| title_short |
Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies |
| title_full |
Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies |
| title_fullStr |
Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies |
| title_full_unstemmed |
Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies |
| title_sort |
Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies |
| author |
Castaneda C.A. |
| author_facet |
Castaneda C.A. Castillo M. Aliaga K. Bernabe L.A. Casavilca S. Sanchez J. Torres-Cabala C.A. Gomez H.L. Mas L. Dunstan J. Cotrina J.M. Abugattas J. Chavez I. Ruiz E. Montenegro P. Rojas V. Orrego E. Galvez-Nino M. Felix B. Landa-Baella M.P. Vidaurre T. Villa M.R. Zevallos R. Taxa L. Guerra H. |
| author_role |
author |
| author2 |
Castillo M. Aliaga K. Bernabe L.A. Casavilca S. Sanchez J. Torres-Cabala C.A. Gomez H.L. Mas L. Dunstan J. Cotrina J.M. Abugattas J. Chavez I. Ruiz E. Montenegro P. Rojas V. Orrego E. Galvez-Nino M. Felix B. Landa-Baella M.P. Vidaurre T. Villa M.R. Zevallos R. Taxa L. Guerra H. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Castaneda C.A. Castillo M. Aliaga K. Bernabe L.A. Casavilca S. Sanchez J. Torres-Cabala C.A. Gomez H.L. Mas L. Dunstan J. Cotrina J.M. Abugattas J. Chavez I. Ruiz E. Montenegro P. Rojas V. Orrego E. Galvez-Nino M. Felix B. Landa-Baella M.P. Vidaurre T. Villa M.R. Zevallos R. Taxa L. Guerra H. |
| dc.subject.none.fl_str_mv |
melanoma |
| topic |
melanoma biomarker cancer cervix density gastric glioblastoma lung lymphocytes macrophages http://purl.org/pe-repo/ocde/ford#1.06.01 |
| dc.subject.es_PE.fl_str_mv |
biomarker cancer cervix density gastric glioblastoma lung lymphocytes macrophages |
| dc.subject.ocde.none.fl_str_mv |
http://purl.org/pe-repo/ocde/ford#1.06.01 |
| description |
Aim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and clinicopathological features in different malignancies. Methods: 209 pathological samples from gastric cancer, cervical cancer (CC), non-small-lung cancer, cutaneous melanoma (CM) and glioblastoma were tested for TIL in hematoxylin eosin, and density of CD3+, CD4+, CD8+, CD20+, CD68+ and CD163+ cells by digital analysis. Results: TIL levels were higher in invasive margin compartments (IMC). TIL in IMC, intratumoral and stromal compartments predicted survival. CC and gastric cancer had higher TIL in intratumoral; CC and CM had higher TIL in stromal compartment and IMC. CM had the highest density of lymphocyte and macrophage populations. CD20 density was associated with survival in the whole series. Conclusion: Standardized evaluation of TIL levels may provide valuable prognostic information in a spectrum of different malignancies. © 2019 Future Medicine Ltd. |
| publishDate |
2019 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/2743 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.2217/bmm-2019-0178 |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-85074446280 |
| url |
https://hdl.handle.net/20.500.12390/2743 https://doi.org/10.2217/bmm-2019-0178 |
| identifier_str_mv |
2-s2.0-85074446280 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Biomarkers in Medicine |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Future Medicine Ltd. |
| publisher.none.fl_str_mv |
Future Medicine Ltd. |
| dc.source.none.fl_str_mv |
reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
| instname_str |
Consejo Nacional de Ciencia Tecnología e Innovación |
| instacron_str |
CONCYTEC |
| institution |
CONCYTEC |
| reponame_str |
CONCYTEC-Institucional |
| collection |
CONCYTEC-Institucional |
| repository.name.fl_str_mv |
Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1844883003524775936 |
| spelling |
Publicationrp07318600rp06447600rp07333600rp07322600rp06445600rp06449600rp07338600rp07340600rp07343600rp07336600rp07334600rp07341600rp06448600rp05755600rp06444600rp07339600rp07342600rp07337600rp07344600rp07319600rp07335600rp07332600rp06457600rp06453600rp01856600Castaneda C.A.Castillo M.Aliaga K.Bernabe L.A.Casavilca S.Sanchez J.Torres-Cabala C.A.Gomez H.L.Mas L.Dunstan J.Cotrina J.M.Abugattas J.Chavez I.Ruiz E.Montenegro P.Rojas V.Orrego E.Galvez-Nino M.Felix B.Landa-Baella M.P.Vidaurre T.Villa M.R.Zevallos R.Taxa L.Guerra H.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2019https://hdl.handle.net/20.500.12390/2743https://doi.org/10.2217/bmm-2019-01782-s2.0-85074446280Aim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and clinicopathological features in different malignancies. Methods: 209 pathological samples from gastric cancer, cervical cancer (CC), non-small-lung cancer, cutaneous melanoma (CM) and glioblastoma were tested for TIL in hematoxylin eosin, and density of CD3+, CD4+, CD8+, CD20+, CD68+ and CD163+ cells by digital analysis. Results: TIL levels were higher in invasive margin compartments (IMC). TIL in IMC, intratumoral and stromal compartments predicted survival. CC and gastric cancer had higher TIL in intratumoral; CC and CM had higher TIL in stromal compartment and IMC. CM had the highest density of lymphocyte and macrophage populations. CD20 density was associated with survival in the whole series. Conclusion: Standardized evaluation of TIL levels may provide valuable prognostic information in a spectrum of different malignancies. © 2019 Future Medicine Ltd.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengFuture Medicine Ltd.Biomarkers in Medicineinfo:eu-repo/semantics/openAccessmelanomabiomarker-1cancer-1cervix-1density-1gastric-1glioblastoma-1lung-1lymphocytes-1macrophages-1http://purl.org/pe-repo/ocde/ford#1.06.01-1Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignanciesinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/2743oai:repositorio.concytec.gob.pe:20.500.12390/27432024-05-30 16:11:00.813http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="980292fc-ab0c-4b71-bb3d-477ff564d879"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies</Title> <PublishedIn> <Publication> <Title>Biomarkers in Medicine</Title> </Publication> </PublishedIn> <PublicationDate>2019</PublicationDate> <DOI>https://doi.org/10.2217/bmm-2019-0178</DOI> <SCP-Number>2-s2.0-85074446280</SCP-Number> <Authors> <Author> <DisplayName>Castaneda C.A.</DisplayName> <Person id="rp07318" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Castillo M.</DisplayName> <Person id="rp06447" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Aliaga K.</DisplayName> <Person id="rp07333" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Bernabe L.A.</DisplayName> <Person id="rp07322" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Casavilca S.</DisplayName> <Person id="rp06445" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Sanchez J.</DisplayName> <Person id="rp06449" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Torres-Cabala C.A.</DisplayName> <Person id="rp07338" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Gomez H.L.</DisplayName> <Person id="rp07340" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Mas L.</DisplayName> <Person id="rp07343" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Dunstan J.</DisplayName> <Person id="rp07336" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Cotrina J.M.</DisplayName> <Person id="rp07334" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Abugattas J.</DisplayName> <Person id="rp07341" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Chavez I.</DisplayName> <Person id="rp06448" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Ruiz E.</DisplayName> <Person id="rp05755" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Montenegro P.</DisplayName> <Person id="rp06444" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Rojas V.</DisplayName> <Person id="rp07339" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Orrego E.</DisplayName> <Person id="rp07342" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Galvez-Nino M.</DisplayName> <Person id="rp07337" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Felix B.</DisplayName> <Person id="rp07344" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Landa-Baella M.P.</DisplayName> <Person id="rp07319" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Vidaurre T.</DisplayName> <Person id="rp07335" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Villa M.R.</DisplayName> <Person id="rp07332" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Zevallos R.</DisplayName> <Person id="rp06457" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Taxa L.</DisplayName> <Person id="rp06453" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Guerra H.</DisplayName> <Person id="rp01856" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Future Medicine Ltd.</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>melanoma</Keyword> <Keyword>biomarker</Keyword> <Keyword>cancer</Keyword> <Keyword>cervix</Keyword> <Keyword>density</Keyword> <Keyword>gastric</Keyword> <Keyword>glioblastoma</Keyword> <Keyword>lung</Keyword> <Keyword>lymphocytes</Keyword> <Keyword>macrophages</Keyword> <Abstract>Aim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and clinicopathological features in different malignancies. Methods: 209 pathological samples from gastric cancer, cervical cancer (CC), non-small-lung cancer, cutaneous melanoma (CM) and glioblastoma were tested for TIL in hematoxylin eosin, and density of CD3+, CD4+, CD8+, CD20+, CD68+ and CD163+ cells by digital analysis. Results: TIL levels were higher in invasive margin compartments (IMC). TIL in IMC, intratumoral and stromal compartments predicted survival. CC and gastric cancer had higher TIL in intratumoral; CC and CM had higher TIL in stromal compartment and IMC. CM had the highest density of lymphocyte and macrophage populations. CD20 density was associated with survival in the whole series. Conclusion: Standardized evaluation of TIL levels may provide valuable prognostic information in a spectrum of different malignancies. © 2019 Future Medicine Ltd.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
| score |
13.427946 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
