Colorectal cancer is the third most frequently diagnosed cancer in both men and women. Adenocarcinoma is the most common pathologic subtype of colon cancer and constitutes 86% of all colon cancers. Nontheless, there are other less frequent sybtyes of colorectal carcinomas, such as adenosquamous carcinoma, an extremely rare form of colon cancer, but with worse prognosis and greater potential of metástasis. We present the case of a 68-year-old female presented with a two-month history of anemia, hematochezia and abdominal pain. The colonoscopic study presented a tumor in the ascending colon, which after surgical resection and pathological studies, turned out to be a primary colonoc adenosquamous carcinoma.

he clinical data and autopsy findings of a case of perinatal listeriosis are presented. Clinical and pathological highlights of this fascinating disease are discussed.

Introducción: El cáncer colorrectal (CCR) es la cuarta neoplasia más frecuente en el mundo y según el origen de las alteraciones en el genoma de las células, el CCR se clasifica en esporádico (~70%) y genético (~30%), éste último involucra a los síndromes hereditarios de predisposición al CCR. Objetivo: Describir los síndromes hereditarios de predisposición al CCR, polipósicos y no polipósicos, identificados en el consultorio de Oncogenética del INEN. Material y métodos: Estudio descriptivo observacional a partir del registro de atenciones en el consultorio de Oncogenética del INEN durante el periodo 2009 al 2013. Se incluyeron a los pacientes con antecedentes personales o familiares de CCR y/o con poliposis colónica que fueron referidos para la evaluación clínica genética al consultorio de Oncogenética del INEN. Resultados: El 59,3% fueron mujeres, 40,7% varones, ...

Mucinous cystic neoplasm (MCN) of the liver is an unusual cyst-forming epithelial neoplasm, typically showing no communication with the bile ducts. This neoplasm represents less than 5% of all cystic lesions of the liver and there are only 250 cases in the world literature. We present the case of a 23-year-old female with a 13.5 x 10.2 cm lesion, hypodense, lobulated, with multiple septa up to 2.5 mm thick and small cystic images inside, which produces intrahepatic bile duct and common bile duct dilatation. The pathological study concluded that the tumor corresponded to a mucinous cystic neoplasm of the liver.

Antecedente: La fibromatosis tipo desmoide es un proceso neoplásico benigno no encapsulado localmente invasivo y agresivo, que se origina de la proliferación de fibroblastos y miofibroblastos aparentemente normales. La localización más frecuente de la fibromatosis es extra-abdominal (60%), pared abdominal (25%) e intra-abdominal (8-15%), en raras ocasiones puede originarse en las vísceras (0,73%), como el páncreas, unión gastroesofágica, diafragma y apéndice. La incidencia anual de tumor desmoide se estima de 2 a 5 casos por millón. En el presente artículo, reportamos un caso de presentación inusual, originado en el apéndice cecal. Caso: Paciente de sexo femenino de 41 años con dolor pélvico agudo, que ingresa a sala de operaciones con diagnóstico clínico y ecográfico de probable tumor de ovario a pedículo torcido. En el intraoperatorio se evidenció una tumoración sÃ...

Testicular cancer is the most common solid tumor in men between ages 15 and 29. It can metastasize through the hematogenous or lymphatic routes to different organs such as the lung and liver (common) and the stomach (uncommon). We present thecase of a 30-year-old male patient with upper gastrointestinal bleeding due to two ulcers in the stomach body with histology of unspecified small-cell malignant neoplasm. CT scans showed a right testicular tumor with secondary implants in the brain, lung, liver and spleen. β-HCG (35,5354 mIU/mL), AFP (500 ng/mL) and LDH (1,669 IU/L) tests were conducted. A right radicalorchiectomy was performed. It is concluded that this was a clinical stage IIIC primary germ cell tumor of the right testis due to liver, spleen, lung, gastric and brain metastases.

Cardiac amyloidosis is a rare clinical entity and, therefore, almost unknown. It shows as a restrictive cardiomyopathy, since it is an infiltrative disease caused by the extracellular deposition of amyloids in the cardiac wall. Although it may be systemic, the heart condition determines its poor prognosis. This is the case of a 38-year-old patient who was admitted for dyspnea and severe fatigue. He was diagnosed with IgA multiple myeloma, lambda light chains, clinical stage IIIB, and initiated treatment with cyclophosphamide, thalidomide and dexamethasone. The patient stopped the treatment, and returned after one year and 2 months with an advanced disease and presence of amyloidosis. The patient progressed torpidly and eventually died. A review of the medical literature is performed concerning amyloidosis types, physiopathology, diagnostic methods and treatment.

Tuberculosis (TB) is a major public health problem that, due to the clinical variability of its presentation, can be confused with cancer. The aim of this study was to identify the clinical-radiological characteristics and to describe the methodology that allowed to achieve a TB diagnosis in patients referred to the National Institute of Neoplastic Diseases (INEN) with a presumed diagnosis of cancer between 2014 and 2016. The study included 170 patients (52.4% men) with an average age of 41.1 years; 18% presented a history of contact with TB, and 5.9% had had the disease previously. The TB was pulmonary in 22.4% and extrapulmonary in 77.7% of patients. The most frequent symptoms were respiratory, tumor, weight loss, and neurological. The cancer diagnoses most frequently discarded were lymphoma, lung cancer, and brain cancer. The lesions that suggested a neoplasm indicated an advanced cli...

The solid pseudopapillary tumor of the pancreas, also known as Frantz's tumor, is a very rare disease in our country, comprising less than 3 % of pancreatic tumors. Its etiology is unknown and it is predominantly found in young women in their third decade of life. We present the case of a 23-year-old woman who was admitted due to a 3-month burning epigastralgia and early satiety. On examination, she had pain with deep palpation. Her biochemical profile, liver profile, and tumor markers were within normal values. An abdomen and pelvis multislice helical/spiral computed tomography (CT) scan showed a solid cystic neoformative lesion with rounded structure and well-defined borders. Pathology confirmed a solid pseudopapillary tumor of the pancreas. The patient underwent a tumor resection with favorable evolution.

We previously described a divergent clinical and molecular presentation of hepatocellular carcinoma (HCC) in Peru. The present study aimed to further characterize the tissue features associated with this singular nosological form of HCC in order to gain insight into the natural history of the disease. We performed an exploratory analysis of the histology of both tumor and non-tumor liver (NTL) tissues from 50 Peruvian HCC patients, and compared with that of 75 individuals with non-HCC liver tumor or benign liver lesions as a baseline for NTL features. We complemented this approach with a transcriptome analysis in a subset of NTL tissue samples and also performed an ultra-sensitive hepatitis B virus (HBV) detection in liver tissues of the patients. Overall, results highlighted the low rate of liver parenchymal alterations in a young patient cohort (median age: 40 years old), despite a str...

OBJETIVOS. El propósito es reportar la experiencia de un único cirujano en una única institución con nefrectomías radicales hecha con técnica abierta, laparoscópica y laparoscópica tridimensional y comparar diversos parámetros perioperatorios entre dichas técnicas. MATERIALES Y MÉTODOS. Evaluamos en forma retrospectiva y analítica diversos parámetros perioperatorios en 130 nefrectomías radicales consecutivas durante los años 2014 al 2020, y los comparamos entre las técnicas abierta, laparoscópica y laparoscópica tridimensional. RESULTADOS. De las 130 nefrectomías radicales, 90 se realizaron con técnica abierta, 28 con cirugía laparoscópica y 12 con laparoscopia tridimensional. No hubo diferencias en edad, sexo, índice de masa corporal, lado afectado, T patológico, duración de la cirugía y porcentaje de transfusiones post operatorias. Encontramos diferencias en l...

OBJETIVOS. El propósito es reportar la experiencia de un único cirujano en una única institución con nefrectomías radicales hecha con técnica abierta, laparoscópica y laparoscópica tridimensional y comparar diversos parámetros perioperatorios entre dichas técnicas. MATERIALES Y MÉTODOS. Evaluamos en forma retrospectiva y analítica diversos parámetros perioperatorios en 130 nefrectomías radicales consecutivas durante los años 2014 al 2020, y los comparamos entre las técnicas abierta, laparoscópica y laparoscópica tridimensional. RESULTADOS. De las 130 nefrectomías radicales, 90 se realizaron con técnica abierta, 28 con cirugía laparoscópica y 12 con laparoscopia tridimensional. No hubo diferencias en edad, sexo, índice de masa corporal, lado afectado, T patológico, duración de la cirugía y porcentaje de transfusiones post operatorias. Encontramos diferencias en l...

OBJETIVOS. El propósito es reportar la experiencia de un único cirujano en una única institución con nefrectomías radicales hecha con técnica abierta, laparoscópica y laparoscópica tridimensional y comparar diversos parámetros perioperatorios entre dichas técnicas. MATERIALES Y MÉTODOS. Evaluamos en forma retrospectiva y analítica diversos parámetros perioperatorios en 130 nefrectomías radicales consecutivas durante los años 2014 al 2020, y los comparamos entre las técnicas abierta, laparoscópica y laparoscópica tridimensional. RESULTADOS. De las 130 nefrectomías radicales, 90 se realizaron con técnica abierta, 28 con cirugía laparoscópica y 12 con laparoscopia tridimensional. No hubo diferencias en edad, sexo, índice de masa corporal, lado afectado, T patológico, duración de la cirugía y porcentaje de transfusiones post operatorias. Encontramos diferencias en l...