Sr. Editor, Con relación a la editorial publicada en el número 2 del volumen 82 de la revista Anales de la Facultad de Medicina, como investigadores de la Unidad de Ensayos Clínicos de la Universidad Nacional Mayor de San Marcos (UNMSM) alcanzamos la siguiente información: Iniciada la pandemia, disponíamos de una reglamentación nacional sobre ensayos clínicos que no respondía a un escenario impredecible de pandemia, por lo que el Instituto Nacional de Salud (INS) realizó modificaciones de emergencia (1) y conformó un comité nacional de ética específico para ensayos clínicos sobre COVID-19 (CNTEI) (2).

Background: Educational environment refers to the material resources and interpersonal relationships of an educational institution. Aim: To describe the educational environment of a Peruvian medical school and to explore a possible association between curricular years and the educational environment. Material and Methods: A cross-sectional study was conducted using the Dundee Ready Education Environment Measure (DREEM) to evaluate the educational environment of a Peruvian medical school. Data collection consisted in online surveys completed voluntarily by 1st through 6th year medical students between April and October 2015. Results: The questionnaire was completed by 828 of 2,421 (34.2%) students. The mean DREEM score was 117 ± 25.6 of a maximum of 200. A poorer perception of the educational environment was associated with later years in the curriculum, when analysis was adjusted for ge...

Introduction: Antimicrobial resistance (AMR) is a worldwide public health crisis. The World Health Organization (WHO) established a priority list of resistant bacteria to guide research and alternatives for improvement. Objective: To describe the scientific production of Peru on AMR of bacteria prioritized by the World Health Organization, between 2012 and 2021. Methods: Observational descriptive study of bibliometric type in journals indexed in Scopus during the period 2012-2021. The selection of studies and data extraction were performed manually in duplicate. Resistant bacteria studied were classified based on priority (critical, high, and medium). Results: A total of 118 articles were included. During the period 2014-2021, the number of publications increased. The articles published in English accounted for 61.9%, 98.3% had their affiliation in Peru, and 77.1% were conducted in Lima....

Background: Tuberculosis has been associated with an increased risk of cardiovascular disease (CVD), including acute myocardial infarction (AMI). We investigated whether latent tuberculosis infection (LTBI) is associated with AMI. Methods: We conducted a case-control study in 2 large national public hospital networks in Lima, Peru, between July 2015 and March 2017. Case patients were patients with a first time diagnosis of type 1 (spontaneous) AMI. Controls were patients without a history of AMI. We excluded patients with known human immunodeficiency virus infection, tuberculosis disease, or prior LTBI treatment. We used the QuantiFERON-TB Gold In-Tube assay to identify LTBI. We used logistic regression modeling to estimate the odds ratio (OR) of LTBI in AMI case patients versus non-AMI controls. Results: We enrolled 105 AMI case patients and 110 non-AMI controls during the study period....

Antecedentes: Anteriormente informamos un aumento de los niveles sanguíneos no estimulados de interferón-gamma en personas con infección tuberculosa latente (LTBI) en los Estados Unidos, lo que sugiere una mayor activación inmunitaria en la LTBI. Para investigar esto más a fondo en un entorno endémico de TB, evaluamos los niveles de interferón-gamma en personas con y sin LTBI en Perú. Métodos: Analizamos datos de pacientes con y sin un infarto agudo de miocardio (IAM) tipo 1 reciente (espontáneo) que fueron inscritos en dos redes de hospitales públicos en Lima, Perú, y se sometieron a pruebas de ITBL utilizando el tubo QuantiFERON® TB Gold In-tube ( QFT) ensayo. Los participantes con una prueba QFT positiva se definieron como pacientes con LTBI, mientras que los participantes con una prueba QFT negativa se definieron como no LTBI. El interferón-gamma no estimulado se cuanti...

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