Introduction. Traffic accidents are one of the leading causes of physical disability in Peru. Physical therapy plays a key role in restoring functionality, and its duration varies depending on several factors. Identifying these factors could improve therapeutic planning and patient follow-up. Objectives. To determine the number of physical therapy sessions and associated factors in patients undergoing post-traffic accident rehabilitation covered by the Mandatory Traffic Accident Insurance (SOAT). Methods. We conducted a cross-sectional study using records of patients treated in 2022 at a specialized physical medicine and rehabilitation center in Lima, Peru. We included individuals aged ≥18 years covered by SOAT. A quasi-Poisson regression model was used to estimate the number of physical therapy sessions. Results. We analyzed 683 medical records. Of the patients, 67.1% were male, and t...

Los accidentes de tránsito son una de las principales causas de discapacidad física en el Perú. La fisioterapia es fundamental para recuperar la funcionalidad y su duración es variable según diversos factores, identificarlos permitiría mejorar la terapéutica y el seguimiento del paciente. Por lo mismo, la investigación tiene por objetivo determinar el número de sesiones de fisioterapia y los factores asociados en pacientes en rehabilitación post accidentes de tránsito bajo la cobertura del Seguro Obligatorio de Accidentes de Tránsito (SOAT). Para ello, se realizó un estudio trasversal con pacientes atendidos en 2022 en un centro especializado en medicina física y rehabilitación en Lima, Perú. Incluimos personas de ≥18 años atendidos con cobertura de SOAT. Aplicamos la regresión de cuasi-Poisson para modelar el número de sesiones de fisioterapia. Analizamos 683 histor...

Objective: PI3K is one of the most frequently mutated proteins in cancer, resulting in changes to its functions in regulating metabolism, immunity, among others. Despite the identification of specific drugs targeting PI3K, significant resistance tothese therapies has been observed. Therefore, the search for new inhibitors is crucial. This project proposes a strategy based on in silico computational tools for screening Food and Drug Administration (FDA)-approved drugs, aiming to evaluate their potential for drug repositioning. Materials and methods: This study obtained the sequence of PI3Kα from UniProt Knowledgebase and its three-dimensional structure from AlphaFold Protein Structure Database, which were then coupled with adenosine triphosphate (ATP) and its selective inhibitors: inavolisib, taselisib, CH5132799, alpelisib and ZSTK474. Drug-protein interaction analysiswas performed usin...