Background: Primary Sjogren's syndrome (pSS) is an autoimmune disease that leads to salivary and lacrimal gland dysfunction. The adaptive immune response associated with T helper-2 lymphocytes appears to be altered in these patients. Therefore, the objective of this study was to determine the salivary levels of interleukin (IL)-6, IL-5, and IL-4 in patients with pSS when compared to a healthy control (HC) group. The secondary objectives were to study whether ILs levels in pSS patients were associated with salivary flow, patient-reported outcomes (PROMs) for xerostomia and oral health quality of life (Oral Health Impact Profile-14 [OHIP-14]), pSS classification criteria and presence of extraglandular manifestations. Methods: A case-control study was conducted in 36 patients with pSS and 35 HCs. Cytokine levels were measured using high-sensitivity multiplex map human immunoassays. Unstimul...

Objectives: Sjögren's syndrome is a complex and heterogeneous autoimmune disease characterised by ocular and oral dryness (1), which mainly affects the exocrine glands. The objective of this study was to determine the prevalence of sicca syndrome (SS) in the Peruvian population. The age and gender of patients with SS and their national prevalence and in each of the departments were defined. Methods: This was a cross-sectional prevalence study. All the people for whom the Ministry of Health (MINSA) in Peru covered health treatments from January to December 2016 were taken into account. The patients with SS were either newly or previously diagnosed with sicca syndrome (Sjögren's) according to the international classification of diseases version 10 (ICD-10) of the World Health Organization (WHO). The prevalence was determined considering the number of cases of SS in the total population r...

The application of additive manufacturing technologies to the construction industry has a wide range of advantages from the economic, social and design flexibility point of view. However, most of up to date research studies have been performed using ordinary Portland cement (OPC)-based mortars and concretes. Therefore, the objective of this article is to explore the development of an eco-friendly earth composite reinforced with natural sisal fibers and chemically stabilized with a hydraulic binder. Analysis of the workability by shear vane tests was performed on fresh earth samples to find the optimum water content in sisal fiber-reinforced earth stabilized with OPC. Afterward, the effect of the addition of OPC on the hardening process was evaluated through shear vane and Vicat needle tests from 0 to 180 min after mixing. The results indicate that water content, fiber addition and OPC re...

The goal of the present research was to establish the relationship cause - effect between drug administration and the presence of acquired aplasic anemia, drug hepatitis and hemorrhagic gastritis, identifying the probable causing drugs. It is applied the deductive analysis by Karch and Lasagna algorithim modilyed by Naranjo et al. The considered criteria for establishing relationship of causality between ethiologic (drug) agent and induced disease were: temporal relationship between suspect drug and induced disease drugs; favorable resolution of the signs, symptoms and lab assay after retirement of probably causing agent; the lab data and clinical analysis that relate in time, the drug and the appearance of the diseases in the study. It was identified 18 cases of acquires aplasic anemia; 15 cases of drug hepatitis and 41 cases of hemorrhagic gastritis. It was concluded that 27,8% of the ...

The goal of the present research was to establish the relationship cause - effect between drug administration and the presence of acquired aplasic anemia, drug hepatitis and hemorrhagic gastritis, identifying the probable causing drugs. It is applied the deductive analysis by Karch and Lasagna algorithim modilyed by Naranjo et al. The considered criteria for establishing relationship of causality between ethiologic (drug) agent and induced disease were: temporal relationship between suspect drug and induced disease drugs; favorable resolution of the signs, symptoms and lab assay after retirement of probably causing agent; the lab data and clinical analysis that relate in time, the drug and the appearance of the diseases in the study. It was identified 18 cases of acquires aplasic anemia; 15 cases of drug hepatitis and 41 cases of hemorrhagic gastritis. It was concluded that 27,8% of the ...

Magnetite (Fe3O4) nanoparticles coated with organic material are of considerable importance in various areas of engineering, as well as in biomedicine. Several papers show drastic changes in the magnetic properties related to the surface effects and the particle-particle interactions strength. However, there is no consensus about the origin or mechanisms that produce these changes, which could be different depending on the particle size and shape, coating efficiency and particle-particle interaction strength. Aiming to shed light on these issues, oleic acid (OA) coated Fe3O4 nanoparticles with different sizes were synthesized by a thermal decomposition method. Structural and microscopic results revealed Fe3O4 nanoparticles with good crystallinity and almost-spherical or polyhedral shapes depending on the solvent used for the synthesis. Infrared (FTIR) spectroscopy indicated OA molecules ...

Introducción: El Linfoma Gástrico Primario es una entidad infrecuente dentro de las neoplasias que afectan el estómago. La histología del Linfoma Gástrico Primario es variada y adquiere connotación especial el Linfoma a células B de la zona marginal extranodal, por su potencial remisiónconlaantibioticoterapia. Objetivos: ApreciarlascaracterísticasclínicasdelospacientesconLinfomaGástricoPrimario, loshallazgosendoscópicosmásrelevantes, identificarlosfactoresqueinfluencianlasupervivenciayevaluarlosefectosdelaterapia. Materialymétodos: Elpresenteestudioesdetipoobservacional, analíticoydecortetransversal, se realizó en 169 pacientes con diagnóstico histológico de Linfoma Gástrico que fueron atendidos en el Instituto Especializado de Enfermedades Neoplásicas, Lima-Perú, desde Enero de 1995 a Diciembre del 2000. Para el estadiaje se utilizó el sistema Ann Arbor modificado ...