En la laguna de Quistococha, se estudió la productividad primaria y la biomasa fitoplanctónica junto con los parámetros físicos y químicos desde el mes de julio a diciembre de 1,999 (época de vaciante). Se determinaron tres estaciones de muestreo y en cada uno de ellos tres estratos de la columna de agua. El método de los frascos claros y oscuros fue para la productividad primaria y la colecta de una muestra de agua por estrato a través de una red de plancton y luego filtrado por un filtro de membrana de 0.47u para la biomasa fitoplantónica. La productividad primaria y la Biomasa variaron significativamente entre las estaciones de muestreo durante todo el periodo de estudio, donde el rango de productividad fue de 0.129 y 0.3766 gCm-3h-t. Tanto la productividad primaria y la Biomasa fueron consistentemente altos en la estación de muestreo Nro. 2 (centro de la laguna). Y básicam...

The purpose of this project was to establish a real-time PCR assay for the detection of SARS-CoV-2 that would use a non-invasive biological sample such as saliva or mid-turbinate swab that would provide results in a short period of time and that would support SARS CoV-2 diagnostic procedures in Iquitos city. This project aimed to compare the internal effectiveness positivity, sensitivity, specificity, and positive predictive value of a molecular diagnostic test for SARS-CoV-2 using extracted RNA from saliva and mid-turbinate swabs versus heat extraction of the same biological samples. This is a cross-sectional, prospective, analytical study. A total of 289 participants were enrolled after they requested a real-time PCR test to detect SARS CoV-2 at the reference laboratory of the Regional Government of Loreto. The Centers for Disease Control of the United States validated primers and prob...

This work was supported by the National Institutes of Health (NIH) 5D43TW009349–03 “Inter-American Training for Innovations in Emerging Infectious Diseases” (to GOL). F. S. was supported by FONDECYT-CONCYTEC (grant contract number 246–2015-FONDECYT), and the UJMT Fogarty Global Health Fellows Consortium comprising Johns Hopkins University, the University of North Carolina, Morehouse University, and Tulane University (NIH Research Training Grant # D43 TW009340 funded by the NIH Fogarty International Center, NINDS, NIMH, NHBLI and NIEHS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Early childhood enteric infections have adverse impacts on child growth and can inhibit normal mucosal responses to oral vaccines, two critical components of environmental enteropathy. To evaluate the role of indoleamine 2,3-dioxygenase 1 (IDO1) activity and its relationship with these outcomes, we measured tryptophan and the kynurenine–tryptophan ratio (KTR) in two longitudinal birth cohorts with a high prevalence of stunting. Children in rural Peru and Tanzania (N = 494) contributed 1,251 plasma samples at 3, 7, 15, and 24 months of age and monthly anthropometrics from 0 to 36 months of age. Tryptophan concentrations were directly associated with linear growth from 1 to 8 months after biomarker assessment. A 1-SD increase in tryptophan concentration was associated with a gain in length-for-age Z-score (LAZ) of 0.17 over the next 6 months in Peru (95% confidence interval [CI] = 0.11�...

Objectives: Antimicrobial resistant (AMR) Campylobacter is a global health threat; however, there is limited information on genomic determinants of resistance in low- and middle-income countries. We evaluated genomic determinants of AMR using a collection of whole genome sequenced Campylobacter jejuni and C. coli isolates from Iquitos, Peru. Methods: Campylobacter isolates from two paediatric cohort studies enriched with isolates that demonstrated resistance to ciprofloxacin and azithromycin were sequenced and mined for AMR determinants. Results: The gyrA mutation leading to the Thr86Ile amino acid change was the only gyrA mutation associated with fluoroquinolone resistance identified. The A2075G mutation in 23S rRNA was present, but three other 23S rRNA mutations previously associated with macrolide resistance were not identified. A resistant-enhancing variant of the cmeABC efflux pump ...