Objetivos: Determinar la eficiencia de la prueba de índice de PSA libre en la práctica clínica hospitalaria. •Diseño: Estudio retrospectivo de evaluación de la prueba de índice de PSA libre. •Lugar: Hospital Nacional Edgardo Rebagliati Martins •Participantes: 371 casos de pacientes sometidos a biopsia prostática, 104 casos de cáncer de Próstata y 267 casos de Hiperplasia Benigna de Próstata. •Intervenciones: Recolección de datos mediante la revisión de registros médicos hospitalarios y revisión de estudios anatomopatologicos. •Principales medidas de resultados: Sensibilidad, especificidad, valor predictivo positivo, valor predictivo negativo, curva ROC (Receiver Operating Characteristic) y el área bajo la curva ROC (ABC). •Resultados: El índice de PSA libre con un punto de corte de 0,20 demostró una sensibilidad de 0,85, especificidad de 0,51, valor predictiv...

• Objetivos: Determinar la eficiencia de la prueba de índice de PSA libre en la práctica clínica hospitalaria. • Diseño: Estudio retrospectivo de evaluación de la prueba de índice de PSA libre. • Lugar: Hospital Nacional Edgardo Rebagliati Martins • Participantes: 371 casos de pacientes sometidos a biopsia prostática, 104 casos de cáncer de Próstata y 267 casos de Hiperplasia Benigna de Próstata. • Intervenciones: Recolección de datos mediante la revisión de registros médicos hospitalarios y revisión de estudios anatomopatologicos. • Principales medidas de resultados: Sensibilidad, especificidad, valor predictivo positivo, valor predictivo negativo, curva ROC (Receiver Operating Characteristic) y el área bajo la curva ROC (ABC). • Resultados: El índice de PSA libre con un punto de corte de 0,20 demostró una sensibilidad de 0,85, especificidad de 0,51, valor...

Introduction: There is limited research on neglected diseases. Medicinal plants are potential sources of antimicrobial compounds. Objectives: To determine the toxicity of Aloysia triphylla essential oil and citral activity against Trypanosoma cruzi in mice. Design: Experimental study in vivo, preclinical. Setting: Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Biological material: Albino mice. Main outcome measures: Signs of toxicity and mortality and parasitemia. Interventions: Acute oral toxicity at single dose was evaluated in albino rats. For trypanocidal activity mice were assigned to the following groups: untreated infected (G1), infected and treated with citral at doses 50, 150 and 300 mg/kg/day (G2, G3 and G4 respectively), infected and treated with benznidazole 100 mg/kg (G5), and uninfected and untreated (G6). Parasitemia was determined individually ...

Introduction: Hypertrophic scarring in the skin represents a serious global public health problem, as it physically and emotionally affects people who suffer from it. This makes it necessary to investigate new alternatives for its prevention and treatment. The objective of the study was to compare the effect of Averrhoa carambola L. (star fruit) on the skin under an animal model of hypertrophic healing. Methods: Experimental study; 10 male New Zealand breed rabbits were used, between 3 and 4 months old, with an average weight of 3 to 3.5Kg. The creation of hypertrophic scars in the ears of rabbits was induced under the model described by Morris et al. One of the groups received 1 mL of a 10% aqueous solution of the lyophilized star fruit, while the other received 1 mL of triamcinolone acetate; in both groups the application was intralesional and weekly in a month. After the treatment, un...

Carvacrol is a phenol monoterpene found in aromatic plants specially in Lamiaceae family, which has been evaluated in an experimental model of breast cancer. However, any proposed mechanism based on its antitumor effect has not been reported. In our previous study, carvacrol showed a protective effect on 7,12-dimethylbenz[α]anthracene- (DMBA-) induced breast cancer in female rats. The main objective in this research was to evaluate by using in silico study the carvacrol on HER2, PI3Kα, mTOR, hERα, PR, and EGFR receptors involved in breast cancer progression by docking analysis, molecular dynamic, and drug-likeness evaluation. A multilevel computational study to evaluate the antitumor potential of carvacrol focusing on the main targets involved in the breast cancer was carried out. The in silico study starts with protein-ligand docking of carvacrol followed by ligand pathway calculatio...