Resultados de Búsqueda por Autor

1

tesis de grado

Incidencia del sistema del control interno en las cuentas por pagar de la Empresa Dalbert Inversiones E.I.R.L.

Publicado por
Arroyo Apaza, Mari Luz, Landa Baella, María de los Ángeles

Publicado 2016

El presente trabajo tiene como problema a investigar la incidencia del Sistema de Control lnterno en las cuentas por pagar de la empresa Dalbet Inversiones E.l.R.L ya que se observó un deficiente control interno en sus cuentas por pagar, incumplimientos en los procedimientos y la inexistencia de políticas en el pago de sus compras; la falta de supervisión y el mal manejo de la separación de funciones.

2

artículo

Prevalence of H. pylori Infection in Relatives of Peruvian Patients with Gastric Cancer

Publicado por
Castillo, Miluska, Bernabe, Luis A., Castaneda, Carlos A., Suarez, Nancy, Barreda, Fernando, Valdivia, Daniel, Ruiz, Eloy, Nieves, Jais, Dias-Neto, Emmanuel, Landa-Baella, Maria, Montano-Flores, Jennifer, Chavez, Ivan

Publicado 2021

Enlace

bjective: The aim of this study was to determine the relationship between Helicobacter pylori (H. pylori) infection in relatives and patients with gastric cancer (GC). Methods: H. pylori infection was evaluated by the breath urease test in 171 relatives and by qPCR technique in gastric tissue of 61 patients (n=45 for GC and n=16 for non-GC). Results: There were included 137 relatives of GC patients and 34 of non-GC. The median age of the relatives of patients with a gastric tissue sample was 39 years (10-86). Infection was found in 60.2% (n=103) relatives. There were no higher H. pylori infection rates in relatives of patients with gastric cancer (62% vs 62.9%, p=0.33), H. pylori infection (60% vs 60%, p=0.96), or metaplasia (58.8% vs 61.8%, p=0.71). Conclusion: The prevalence of infection in relatives of GC patients is high in our population but not associated with H. pylori presence in...

3

artículo

Detection of Helicobacter pylori in gastric cancer tissue through histopathology, immunohistochemistry and real-time reverse transcription-PCR

Publicado por
Castaneda, Carlos A, Castillo, Miluska, Sanchez, Joselyn, Casavilca, Sandro, Sanchez, Juvenal, Bernabe, Luis A, Suarez, Nancy, Chavez, Ivan, Ruiz, Eloy, Tello, Katherine, Villa, Maria R, Zevallos, Rocio, Montenegro, Paola, Dias-Neto, Emmanuel, Landa-Baella, Maria, Taxa, Luis

Publicado 2020

Enlace

Aim:Helicobacter pylori is usually detected based on hematoxylin-eosin (H-E) features, but, immunohistochemistry (IHC) and real-time PCR (RT-PCR) are more precise in chronic-gastritis. We evaluated the relevance of these tests in Peruvian gastric cancer samples. Materials & methods: We performed and evaluated H-E, IHC staining and RT-PCR in 288 gastric tumors. Slides were independently evaluated by three pathologists. Results:H. pylori was detected in 167/287 through H-E, 140/288 through IHC and 175/288 through RT-PCR, and positive-status were associated (p < 0.001). H. pylori detection by H-E had a good concordance with IHC (kappa index = 0.632) but poor with RT-PCR (kappa index = 0.317). Higher median gene-copies were found in high H. pylori density through H-E or IHC (p < 0.001). Conclusion: H-E evaluation is accurate in gastric cancer, and IHC and RT-PCR can complement its ...

4

artículo

Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies

Publicado por
Castañeda, Carlos A., Castillo, Miluska, Aliaga, Karina, Bernabé, Luis A., Casavilca, Sandro, Sánchez, Joselyn, Torres-Cabala, Carlos A., Gómez , Henry L., Mas, Luis, Dunstan, Jorge, Cotrina, José M, Abugattas, Julio, Chávez, Iván, Ruiz, Eloy, Montenegro, Paola, Rojas, Víctor, Orrego, Enrique, Gálvez-Nino, Marco, Félix , Brayam, Landa-Baella, María P., Vidaurre, Tatiana, Villa, María R, Zevallos, Rocío, Taxa, Luis, Guerra, Henry

Publicado 2019

Enlace

Aim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and clinicopathological features in different malignancies. Methods: 209 pathological samples from gastric cancer, cervical cancer (CC), non-small-lung cancer, cutaneous melanoma (CM) and glioblastoma were tested for TIL in hematoxylin eosin, and density of CD3+, CD4+, CD8+, CD20+, CD68+ and CD163+ cells by digital analysis. Results: TIL levels were higher in invasive margin compartments (IMC). TIL in IMC, intratumoral and stromal compartments predicted survival. CC and gastric cancer had higher TIL in intratumoral; CC and CM had higher TIL in stromal compartment and IMC. CM had the highest density of lymphocyte and macrophage populations. CD20 density was associated with survival in the ...