Se presenta un caso clínico de la enfermedad de Wilson. Una mujer de 26 años de edad, comenzó a mostrar trastornos psíquicos, a los que se añadieron signos neurológicos, tales como temblor asimétrico de las manos, parkinsonismo, distonía; últimamente, presentó mutismo y disfagia. La exploración oftalmológica demostró la presencia del anillo de Kayser - Fleischer en la membrana de Descemet. Se comprobó alteración del metabolismo del cobre en cuanto a reducción de la ceruloplasmina sérica y aumento de la excreción urinaria de cobre. Mediante laparoscopía y biopsia se puso en evidencia cirrosis hepática. La investigación de las estructuras del encéfalo con resonancia magnética (IRM) reveló atrofia frontotemporal del cerebro, y proceso degenerativo de los ganglios basales, el cerebelo y el tronco encefálico, datos que pueden ser utilizados para sugerir la probable fi...

The case of a 73 years-old woman that, since approximately the age of 30 years started to complain of pain when walking, is presented. The symptom was mainly located in the acchillean regions which, as time advanced, showed gradual volume increase and, finally, forced her to seek medical evaluation. Accompanying relatives reported a several years’ history of gradually increasing cognitive difficulties (i.e., forgetfulness, disorientation, poor attention and concentration), fluctuating mood (from periods of good humor switching to sudden episodes of sadness and crying spells), emotional lability and anxiety crises evolving into brief panic attacks. The Mini-cognitive Fenton Test confirmed severe dementia and the neurological evaluation showed cerebellar ataxia and partial pyramidalism. The ophthalmological examination revealed xanthelasmas, cataracts and dense arcus senilis. Xanthomas we...

The case of a 32 years old. male patient who since age 17 has experienced constrictive headaches of several minutes’ duration, triggered by physical effort is reported. For the last seven years there, he has presented a progressive cognitive decline cognitive, and marked personality changes, having become extremely dependent even for conducting elemental activities. At the age of 27, he experienced total left hemiplegia from which he completely recovered in two weeks. He also shows severe confusional states and child-like behavior. Laboratory tests ruled out heart disease, atherosclerosis and systemic autoimmune diseases. Brain neuroimaging tests (CT, Angio – TEM and contrasted cerebral MRI) revealed the occurrence of six cerebral infarcts, in subacute and chronic stages, severe stenosis of the anterior cerebral arteries, and presence of microaneurysm in the M segment of the left mid...

The neurological and psychiatric manifestations in two patients who met clinical criteria of Behcet’s disease are observed and described throughout several decades. The presence of recurrent oral and genital canker sores is illustrated with images. One of the patients developed thrombosis of the femoral vein, and erythema nodosus was present in both. The ophthalmological evaluation showed absence of uveitis in both patients, and blindness by adult monocular dystrophic maculopathy without signs of retinal vasculitis in the female. Laboratory tests on blood and cerebrospinal fluid evidenced lymphocytic pleocytosis. The patergia skin test was negative. Likewise, laboratory tests determined an absence of findings compatible with other autoimmune diseases. Throughout the evaluation period, the clinical manifestations were correlated with the findings from tomography and brain magnetic reson...