Objective: Paraoxonase 1 (PON1), an esterase associated with high-density lipoproteins (HDL), has several polymorphisms: the PON1 Q192R polymorphism (coding region) is responsible for variations in the paraoxonase activity of the enzyme. The PON1 192R allele is considered a risk factor for developing cardiometabolic disorders in some populations. The aim of the present study is to determine the distribution of the PON1 Q192R polymorphism and its association with the lipid profile and APO A1 in an Andean population. Materials and methods: A descriptive, cross-sectional study involving 79 healthy adults (26 males and 53 females), residents of the district of Junín at 4105 m.a.s.l. The PCR/RFLP technique was used for the analysis of the PON1 Q192R polymorphism. The serum values of the lipid profile and APO A1, and the paraoxonase and arylesterase activities of the enzyme were determined. R...

Objectives: To determine the serum levels of sCD36, a lipid metabolism-related molecule, in high-altitude and sea-level populations, and to establish the association of this parameter with cardiometabolic risk factors. Materials and methods: The study population consisted of 45 people from Carhuamayo (4100 masl) and 40 people from Mala (30 masl). Weight, height and blood pressure were measured. Hemoglobin was determined in whole blood, and glucose, lipid profile and sCD36 in serum. Results: It has been found that hemoglobin levels in the population of Carhuamayo were significantly higher, while weight, BMI and glucose level were significantly lower than those in the population of Mala. There was no significant difference between serum levels of sCD36 in both populations. A significant difference was observed between sCD36 mean serum levels of both populations based on the BMI, and a sign...

In the present study, it was measured the Paraoxonase-1 (PON1) activity and phenotypes in 89 universities students from Lima-Peru, because previous studies ha ve reported that the PON1 192 Q/R polymorphism could affect the organophosphorus and drug metabolism as well as its protective effect against to development of atherosclerosis. It has found that the mean PON1 activity in the studied population was 167.01 ± 60.84 U/L. The AA, AB Y BB phenotypes from PON1 activity shown frequencies of 0.236, 0.573 and 0.191 respectively. In the studied population PON1 activity has a unimodal distribution and there are more heterozygous individuals AB than homozygous AA or BB. The knowledge of PON1 activity and phenotypes in various populations could be useful for identifying individuals who are more prone to the organophosphorus toxicity or who ha ve a high risk to developed aterosclerosis, and to p...

In the present study, it was measured the Paraoxonase-1 (PON1) activity and phenotypes in 89 universities students from Lima-Peru, because previous studies ha ve reported that the PON1 192 Q/R polymorphism could affect the organophosphorus and drug metabolism as well as its protective effect against to development of atherosclerosis. It has found that the mean PON1 activity in the studied population was 167.01 ± 60.84 U/L. The AA, AB Y BB phenotypes from PON1 activity shown frequencies of 0.236, 0.573 and 0.191 respectively. In the studied population PON1 activity has a unimodal distribution and there are more heterozygous individuals AB than homozygous AA or BB. The knowledge of PON1 activity and phenotypes in various populations could be useful for identifying individuals who are more prone to the organophosphorus toxicity or who ha ve a high risk to developed aterosclerosis, and to p...