Se evaluó el efecto del tiempo de exposición a las grandes alturas sobre la oxidación de proteínas y lípidos del tejido cerebral de cobayos nativos del nivel del mar trasladados a las grandes alturas (Morococha, 4540 m), y sacrificados los días 1, 3, 7 y 14 después de su arribo. Se determinó los niveles medios de cuerpos carbonílicos (CC), malondialdehído (MDA) e hidroperóxidos lipídicos (LOOH) como marcadores de la oxidación de proteínas y lípidos respectivamente; así como, las actividades de las enzimas antioxidantes superóxido dismutasa (SOD), catalasa (CAT) y glutation peroxidasa (GPx) y fosfolipasa A2 (FLA2) como mediadora de la peroxidación lipídica. Se encontró niveles de CC, LOOH y MDA incrementados al primer día; CC disminuyó por debajo del control al tercer día, LOOH mantuvo la tendencia a disminuir y MDA mantuvo sus niveles altos. Las actividades de las ...

In the present study, it was measured the Paraoxonase-1 (PON1) activity and phenotypes in 89 universities students from Lima-Peru, because previous studies ha ve reported that the PON1 192 Q/R polymorphism could affect the organophosphorus and drug metabolism as well as its protective effect against to development of atherosclerosis. It has found that the mean PON1 activity in the studied population was 167.01 ± 60.84 U/L. The AA, AB Y BB phenotypes from PON1 activity shown frequencies of 0.236, 0.573 and 0.191 respectively. In the studied population PON1 activity has a unimodal distribution and there are more heterozygous individuals AB than homozygous AA or BB. The knowledge of PON1 activity and phenotypes in various populations could be useful for identifying individuals who are more prone to the organophosphorus toxicity or who ha ve a high risk to developed aterosclerosis, and to p...

In the present study, it was measured the Paraoxonase-1 (PON1) activity and phenotypes in 89 universities students from Lima-Peru, because previous studies ha ve reported that the PON1 192 Q/R polymorphism could affect the organophosphorus and drug metabolism as well as its protective effect against to development of atherosclerosis. It has found that the mean PON1 activity in the studied population was 167.01 ± 60.84 U/L. The AA, AB Y BB phenotypes from PON1 activity shown frequencies of 0.236, 0.573 and 0.191 respectively. In the studied population PON1 activity has a unimodal distribution and there are more heterozygous individuals AB than homozygous AA or BB. The knowledge of PON1 activity and phenotypes in various populations could be useful for identifying individuals who are more prone to the organophosphorus toxicity or who ha ve a high risk to developed aterosclerosis, and to p...