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This study integrates U-Pb zircon geochronology (from LAM-ICP-MS, SHRIMP, and TIMS) with Nd isotopic data from orthogneisses and metasedimentary rocks of the pre-Mesozoic basement of the eastern Peruvian Andes to provide new information on the tectonic evolution and Neoproterozoic-Paleozoic paleogeography of this segment of the protoAndean margin. A high-grade orthogneiss unit yields U-Pb zircon protolith crystallization ages of ∼613 Ma. It was metamorphosed and intruded by an Early Ordovician granitoid. Subsequently, two different volcano-sedimentary sequences were laid down and metamorphosed, probably as a consequence of terrane accretion. The older sequence was deposited and metamorphosed between 450 and 420 Ma, and the younger one was deposited after 320 Ma and metamorphosed at 310 Ma. U-Pb detrital zircon age patterns from the two sequences are within the age intervals 315–480, ...