Consejo Nacional de Ciencia y Tecnología (CONCYTEC) is acknowledged for PhD funding of Pedro Vásquez-Ocmín.

The gut microbiota of insects is composed of a wide range of microorganisms which produce bioactive compounds that protect their host from pathogenic attack. In the present study, we isolate and identify the fungus Chrysosporium multifidum from the gut of Hermetia illucens larvae. Extract from C. multifidum culture broth supernatant showed moderate activity against a strain of methicillin-resistant Staphylococcus aureus (MRSA). Bioguided isolation of the extract resulted in the characterization of six ?-pyrone derivatives (1-6) and one diketopiperazine (7). Of these compounds, 5,6-dihydro-4-methoxy-6-(1-oxopentyl)-2Hpyran- 2-one (4) showed the greatest activity (IC50 = 11.4 ± 0.7 ?g/mL and MIC = 62.5 ?g/ mL) against MRSA. © 2019 Correa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribut...

The authors thank the Consejo de Ciencia y Tecnología del Perú (CONCYTEC) (Council for science and technology of Peru) (299 - 2014 - FONDECYT) for the Ph.D. scholarship (PGVO). Authors are indebted to the communities cited in this work for their essential contribution in order to spread their ancestral knowledge in favor of science. We also appreciate the important collaboration of Lizardo Fachin Malaverri, Stéphanie Denis, Dennis del Castillo Torres and Juan Vásquez Briones