Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity

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Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both...

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Detalles Bibliográficos
Autores: Barrera Tomas, Melissa, Tomas Chota, Gloria Eva, Sheen Cortavarría, Patricia, Fuentes Bonilla, Patricia, Inocente Camones, Miguel Angel, Contreras, Julio Santiago
Formato: artículo
Fecha de Publicación:2017
Institución:Universidad de San Martín de Porres
Repositorio:USMP-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.usmp.edu.pe:20.500.12727/6135
Enlace del recurso:https://hdl.handle.net/20.500.12727/6135
https://doi.org/10.15446/rev.colomb.quim.v46n3.61980
Nivel de acceso:acceso abierto
Materia:Isoniazida
Mycobacterium tuberculosis
Hidrazonas
https://purl.org/pe-repo/ocde/ford#3.02.00
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spelling Barrera Tomas, MelissaTomas Chota, Gloria EvaSheen Cortavarría, PatriciaFuentes Bonilla, PatriciaInocente Camones, Miguel AngelContreras, Julio Santiago2020-06-01T21:26:14Z2020-06-01T21:26:14Z2017Barrera M., Tomas GE., Sheen P., Fuente P., Inocente MA., Contreras JS. Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity. Revista Colombiana de Química. 2017; 46(3): 17-21.https://hdl.handle.net/20.500.12727/6135https://doi.org/10.15446/rev.colomb.quim.v46n3.61980Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its anti-Mycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively.pp. 17-21engDepartamento de Química, Universidad Nacional de ColombiaCOurn:issn:0036-3634Revista Colombiana de Química;vol. 46, no. 3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/Repositorio Académico USMPUniversidad de San Martín de Porres - USMPreponame:USMP-Institucionalinstname:Universidad de San Martín de Porresinstacron:USMPIsoniazidaMycobacterium tuberculosisHidrazonashttps://purl.org/pe-repo/ocde/ford#3.02.00Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activitySíntesis de acil-hidrazona a partir del ácido úsnico e isoniazida y su actividad anti-Mycobacterium tuberculosisinfo:eu-repo/semantics/articleMedicina HumanaUniversidad de San Martín de Porres. Facultad de Medicina HumanaMedicinaORIGINALinocentes_cmafmh-2017.pdfinocentes_cmafmh-2017.pdfTrabajoapplication/pdf1360107https://repositorio.usmp.edu.pe/bitstream/20.500.12727/6135/1/inocentes_cmafmh-2017.pdfa3c4e8ceeb278c9f6883e450e155db0eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.usmp.edu.pe/bitstream/20.500.12727/6135/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTinocentes_cmafmh-2017.pdf.txtinocentes_cmafmh-2017.pdf.txtExtracted texttext/plain26134https://repositorio.usmp.edu.pe/bitstream/20.500.12727/6135/3/inocentes_cmafmh-2017.pdf.txt4ebba4290b4f42a3245f26552e070ba4MD53THUMBNAILinocentes_cmafmh-2017.pdf.jpginocentes_cmafmh-2017.pdf.jpgGenerated Thumbnailimage/jpeg7304https://repositorio.usmp.edu.pe/bitstream/20.500.12727/6135/4/inocentes_cmafmh-2017.pdf.jpg5510fb43075f1cb4beff8db69742484aMD5420.500.12727/6135oai:repositorio.usmp.edu.pe:20.500.12727/61352025-08-15 11:07:05.925REPOSITORIO ACADEMICO USMPrepositorio@usmp.pe
dc.title.es_PE.fl_str_mv Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
dc.title.alternative.es_PE.fl_str_mv Síntesis de acil-hidrazona a partir del ácido úsnico e isoniazida y su actividad anti-Mycobacterium tuberculosis
title Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
spellingShingle Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
Barrera Tomas, Melissa
Isoniazida
Mycobacterium tuberculosis
Hidrazonas
https://purl.org/pe-repo/ocde/ford#3.02.00
title_short Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
title_full Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
title_fullStr Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
title_full_unstemmed Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
title_sort Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
author Barrera Tomas, Melissa
author_facet Barrera Tomas, Melissa
Tomas Chota, Gloria Eva
Sheen Cortavarría, Patricia
Fuentes Bonilla, Patricia
Inocente Camones, Miguel Angel
Contreras, Julio Santiago
author_role author
author2 Tomas Chota, Gloria Eva
Sheen Cortavarría, Patricia
Fuentes Bonilla, Patricia
Inocente Camones, Miguel Angel
Contreras, Julio Santiago
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Barrera Tomas, Melissa
Tomas Chota, Gloria Eva
Sheen Cortavarría, Patricia
Fuentes Bonilla, Patricia
Inocente Camones, Miguel Angel
Contreras, Julio Santiago
dc.subject.es_PE.fl_str_mv Isoniazida
Mycobacterium tuberculosis
Hidrazonas
topic Isoniazida
Mycobacterium tuberculosis
Hidrazonas
https://purl.org/pe-repo/ocde/ford#3.02.00
dc.subject.ocde.es_PE.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.02.00
description Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its anti-Mycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively.
publishDate 2017
dc.date.accessioned.none.fl_str_mv 2020-06-01T21:26:14Z
dc.date.available.none.fl_str_mv 2020-06-01T21:26:14Z
dc.date.issued.fl_str_mv 2017
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.citation.es_PE.fl_str_mv Barrera M., Tomas GE., Sheen P., Fuente P., Inocente MA., Contreras JS. Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity. Revista Colombiana de Química. 2017; 46(3): 17-21.
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12727/6135
dc.identifier.doi.none.fl_str_mv https://doi.org/10.15446/rev.colomb.quim.v46n3.61980
identifier_str_mv Barrera M., Tomas GE., Sheen P., Fuente P., Inocente MA., Contreras JS. Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity. Revista Colombiana de Química. 2017; 46(3): 17-21.
url https://hdl.handle.net/20.500.12727/6135
https://doi.org/10.15446/rev.colomb.quim.v46n3.61980
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv urn:issn:0036-3634
dc.relation.ispartofseries.none.fl_str_mv Revista Colombiana de Química;vol. 46, no. 3
dc.rights.es_PE.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.es_PE.fl_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
dc.format.extent.es_PE.fl_str_mv pp. 17-21
dc.publisher.es_PE.fl_str_mv Departamento de Química, Universidad Nacional de Colombia
dc.publisher.country.es_PE.fl_str_mv CO
dc.source.none.fl_str_mv Repositorio Académico USMP
Universidad de San Martín de Porres - USMP
reponame:USMP-Institucional
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instacron:USMP
instname_str Universidad de San Martín de Porres
instacron_str USMP
institution USMP
reponame_str USMP-Institucional
collection USMP-Institucional
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Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
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