Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity

• Autores: Barrera Tomas, Melissa, Tomas Chota, Gloria Eva, Sheen Cortavarría, Patricia, Fuentes Bonilla, Patricia, Inocente Camones, Miguel Angel, Contreras, Julio Santiago
• Formato: artículo
• Fecha de Publicación: 2017
• Institución: Universidad de San Martín de Porres
• Repositorio: USMP-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.usmp.edu.pe:20.500.12727/6135
• Enlace del recurso: https://hdl.handle.net/20.500.12727/6135; https://doi.org/10.15446/rev.colomb.quim.v46n3.61980
• Nivel de acceso: acceso abierto
• Materia: Isoniazida; Mycobacterium tuberculosis; Hidrazonas; https://purl.org/pe-repo/ocde/ford#3.02.00

Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its anti-Mycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively.