Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model
Descripción del Articulo
Studies have proposed that Porphyromonas gingivalis (Pg) and Tannerella forsythia (Tf) promote a nonspecific inflammatory response that could produce systemic disease. Oral inoculation of Pg and Tf on the immune and arthritis response was evaluated in BALB/C mice divided into four groups: (1) sham;...
Autores: | , , , , , , , |
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Formato: | artículo |
Fecha de Publicación: | 2017 |
Institución: | Universidad de San Martín de Porres |
Repositorio: | USMP-Institucional |
Lenguaje: | inglés |
OAI Identifier: | oai:repositorio.usmp.edu.pe:20.500.12727/6136 |
Enlace del recurso: | https://hdl.handle.net/20.500.12727/6136 https://doi.org/10.1155/2017/2052938 |
Nivel de acceso: | acceso abierto |
Materia: | Infecciones Porphyromonas gingivalis Tannerella forsythia Artritis reumatoide https://purl.org/pe-repo/ocde/ford#3.02.00 |
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dc.title.es_PE.fl_str_mv |
Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model |
title |
Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model |
spellingShingle |
Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model Hernández-Aguas, Jorday Infecciones Porphyromonas gingivalis Tannerella forsythia Artritis reumatoide https://purl.org/pe-repo/ocde/ford#3.02.00 |
title_short |
Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model |
title_full |
Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model |
title_fullStr |
Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model |
title_full_unstemmed |
Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model |
title_sort |
Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model |
author |
Hernández-Aguas, Jorday |
author_facet |
Hernández-Aguas, Jorday Montiel-Hernández, José Luis De La Garza-Ramos, Myriam A. Ruiz-Ramos, Rosa Velia Escamilla García, Erandi Guzmán-García, Mario Alberto Ayón-Haro, Esperanza Raquel Garza-Elizondo, Mario Alberto |
author_role |
author |
author2 |
Montiel-Hernández, José Luis De La Garza-Ramos, Myriam A. Ruiz-Ramos, Rosa Velia Escamilla García, Erandi Guzmán-García, Mario Alberto Ayón-Haro, Esperanza Raquel Garza-Elizondo, Mario Alberto |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Hernández-Aguas, Jorday Montiel-Hernández, José Luis De La Garza-Ramos, Myriam A. Ruiz-Ramos, Rosa Velia Escamilla García, Erandi Guzmán-García, Mario Alberto Ayón-Haro, Esperanza Raquel Garza-Elizondo, Mario Alberto |
dc.subject.es_PE.fl_str_mv |
Infecciones Porphyromonas gingivalis Tannerella forsythia Artritis reumatoide |
topic |
Infecciones Porphyromonas gingivalis Tannerella forsythia Artritis reumatoide https://purl.org/pe-repo/ocde/ford#3.02.00 |
dc.subject.ocde.es_PE.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.02.00 |
description |
Studies have proposed that Porphyromonas gingivalis (Pg) and Tannerella forsythia (Tf) promote a nonspecific inflammatory response that could produce systemic disease. Oral inoculation of Pg and Tf on the immune and arthritis response was evaluated in BALB/C mice divided into four groups: (1) sham; (2) food contaminated with Pg/Tf; (3) complete Freund’s adjuvant (CFA) + Pg/Tf; and (4) CFA alone. CFA was administered subcutaneously on days 1 and 14. The arthritis response was monitored for 21 days after day 14 of CFA administration. IL-1β and IL-6 were determined in serum. T cell activation was evaluated by CD25 in salivary lymph nodes or mouse spleen. Pad inflammation appeared by day 19 in the CFA group, but animals with bacteria inoculation presented a delay. A significant increase in IL-6 was found in Groups 3 and 4, but not with respect to IL-1β. We observed an increase in CD25 in cells derived from cervical nodes and in animals with bacteria inoculation and CFA. A local immune response was observed in mice inoculated with Pg and Tf (T cell activation); a systemic response was observed with CFA. Since pad inflammation was delayed by bacterial inoculation this suggests that local T cell activation could decrease pad inflammation. |
publishDate |
2017 |
dc.date.accessioned.none.fl_str_mv |
2020-06-01T21:26:44Z |
dc.date.available.none.fl_str_mv |
2020-06-01T21:26:44Z |
dc.date.issued.fl_str_mv |
2017-06-06 |
dc.type.es_PE.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
dc.identifier.citation.es_PE.fl_str_mv |
Hernández J., Montiel JL., De La Garza MA., Ruiz RV., Escamilla E., Guzman MA., et al. Subchronic infection of porphyromonas gingivalis and tannerella forsythia stimulates an Immune response but not arthritis in experimental murine model. Int J Dent. 2017; 2017: 2052938. |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12727/6136 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1155/2017/2052938 |
identifier_str_mv |
Hernández J., Montiel JL., De La Garza MA., Ruiz RV., Escamilla E., Guzman MA., et al. Subchronic infection of porphyromonas gingivalis and tannerella forsythia stimulates an Immune response but not arthritis in experimental murine model. Int J Dent. 2017; 2017: 2052938. |
url |
https://hdl.handle.net/20.500.12727/6136 https://doi.org/10.1155/2017/2052938 |
dc.language.iso.es_PE.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
urn:issn:2340-3152 |
dc.relation.ispartofseries.none.fl_str_mv |
International Journal of Dentistry;vol. 2017 |
dc.rights.es_PE.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.uri.es_PE.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
dc.format.extent.es_PE.fl_str_mv |
2052938 |
dc.publisher.es_PE.fl_str_mv |
Hindawi |
dc.publisher.country.es_PE.fl_str_mv |
GB |
dc.source.es_PE.fl_str_mv |
Repositorio Académico USMP Universidad de San Martín de Porres - USMP |
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Hernández-Aguas, JordayMontiel-Hernández, José LuisDe La Garza-Ramos, Myriam A.Ruiz-Ramos, Rosa VeliaEscamilla García, ErandiGuzmán-García, Mario AlbertoAyón-Haro, Esperanza RaquelGarza-Elizondo, Mario Alberto2020-06-01T21:26:44Z2020-06-01T21:26:44Z2017-06-06Hernández J., Montiel JL., De La Garza MA., Ruiz RV., Escamilla E., Guzman MA., et al. Subchronic infection of porphyromonas gingivalis and tannerella forsythia stimulates an Immune response but not arthritis in experimental murine model. Int J Dent. 2017; 2017: 2052938.https://hdl.handle.net/20.500.12727/6136https://doi.org/10.1155/2017/2052938Studies have proposed that Porphyromonas gingivalis (Pg) and Tannerella forsythia (Tf) promote a nonspecific inflammatory response that could produce systemic disease. Oral inoculation of Pg and Tf on the immune and arthritis response was evaluated in BALB/C mice divided into four groups: (1) sham; (2) food contaminated with Pg/Tf; (3) complete Freund’s adjuvant (CFA) + Pg/Tf; and (4) CFA alone. CFA was administered subcutaneously on days 1 and 14. The arthritis response was monitored for 21 days after day 14 of CFA administration. IL-1β and IL-6 were determined in serum. T cell activation was evaluated by CD25 in salivary lymph nodes or mouse spleen. Pad inflammation appeared by day 19 in the CFA group, but animals with bacteria inoculation presented a delay. A significant increase in IL-6 was found in Groups 3 and 4, but not with respect to IL-1β. We observed an increase in CD25 in cells derived from cervical nodes and in animals with bacteria inoculation and CFA. A local immune response was observed in mice inoculated with Pg and Tf (T cell activation); a systemic response was observed with CFA. Since pad inflammation was delayed by bacterial inoculation this suggests that local T cell activation could decrease pad inflammation.ProyectoProinnova-CONACYT Steripharma, Grant no. 141616.2052938engHindawiGBurn:issn:2340-3152International Journal of Dentistry;vol. 2017info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/Repositorio Académico USMPUniversidad de San Martín de Porres - USMPreponame:USMP-Institucionalinstname:Universidad de San Martín de Porresinstacron:USMPInfeccionesPorphyromonas gingivalisTannerella forsythiaArtritis reumatoidehttps://purl.org/pe-repo/ocde/ford#3.02.00Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine modelinfo:eu-repo/semantics/articleMedicina HumanaUniversidad de San Martín de Porres. 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La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).