Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model

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Studies have proposed that Porphyromonas gingivalis (Pg) and Tannerella forsythia (Tf) promote a nonspecific inflammatory response that could produce systemic disease. Oral inoculation of Pg and Tf on the immune and arthritis response was evaluated in BALB/C mice divided into four groups: (1) sham;...

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Detalles Bibliográficos
Autores: Hernández-Aguas, Jorday, Montiel-Hernández, José Luis, De La Garza-Ramos, Myriam A., Ruiz-Ramos, Rosa Velia, Escamilla García, Erandi, Guzmán-García, Mario Alberto, Ayón-Haro, Esperanza Raquel, Garza-Elizondo, Mario Alberto
Formato: artículo
Fecha de Publicación:2017
Institución:Universidad de San Martín de Porres
Repositorio:USMP-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.usmp.edu.pe:20.500.12727/6136
Enlace del recurso:https://hdl.handle.net/20.500.12727/6136
https://doi.org/10.1155/2017/2052938
Nivel de acceso:acceso abierto
Materia:Infecciones
Porphyromonas gingivalis
Tannerella forsythia
Artritis reumatoide
https://purl.org/pe-repo/ocde/ford#3.02.00
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dc.title.es_PE.fl_str_mv Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model
title Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model
spellingShingle Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model
Hernández-Aguas, Jorday
Infecciones
Porphyromonas gingivalis
Tannerella forsythia
Artritis reumatoide
https://purl.org/pe-repo/ocde/ford#3.02.00
title_short Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model
title_full Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model
title_fullStr Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model
title_full_unstemmed Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model
title_sort Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model
author Hernández-Aguas, Jorday
author_facet Hernández-Aguas, Jorday
Montiel-Hernández, José Luis
De La Garza-Ramos, Myriam A.
Ruiz-Ramos, Rosa Velia
Escamilla García, Erandi
Guzmán-García, Mario Alberto
Ayón-Haro, Esperanza Raquel
Garza-Elizondo, Mario Alberto
author_role author
author2 Montiel-Hernández, José Luis
De La Garza-Ramos, Myriam A.
Ruiz-Ramos, Rosa Velia
Escamilla García, Erandi
Guzmán-García, Mario Alberto
Ayón-Haro, Esperanza Raquel
Garza-Elizondo, Mario Alberto
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Hernández-Aguas, Jorday
Montiel-Hernández, José Luis
De La Garza-Ramos, Myriam A.
Ruiz-Ramos, Rosa Velia
Escamilla García, Erandi
Guzmán-García, Mario Alberto
Ayón-Haro, Esperanza Raquel
Garza-Elizondo, Mario Alberto
dc.subject.es_PE.fl_str_mv Infecciones
Porphyromonas gingivalis
Tannerella forsythia
Artritis reumatoide
topic Infecciones
Porphyromonas gingivalis
Tannerella forsythia
Artritis reumatoide
https://purl.org/pe-repo/ocde/ford#3.02.00
dc.subject.ocde.es_PE.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.02.00
description Studies have proposed that Porphyromonas gingivalis (Pg) and Tannerella forsythia (Tf) promote a nonspecific inflammatory response that could produce systemic disease. Oral inoculation of Pg and Tf on the immune and arthritis response was evaluated in BALB/C mice divided into four groups: (1) sham; (2) food contaminated with Pg/Tf; (3) complete Freund’s adjuvant (CFA) + Pg/Tf; and (4) CFA alone. CFA was administered subcutaneously on days 1 and 14. The arthritis response was monitored for 21 days after day 14 of CFA administration. IL-1β and IL-6 were determined in serum. T cell activation was evaluated by CD25 in salivary lymph nodes or mouse spleen. Pad inflammation appeared by day 19 in the CFA group, but animals with bacteria inoculation presented a delay. A significant increase in IL-6 was found in Groups 3 and 4, but not with respect to IL-1β. We observed an increase in CD25 in cells derived from cervical nodes and in animals with bacteria inoculation and CFA. A local immune response was observed in mice inoculated with Pg and Tf (T cell activation); a systemic response was observed with CFA. Since pad inflammation was delayed by bacterial inoculation this suggests that local T cell activation could decrease pad inflammation.
publishDate 2017
dc.date.accessioned.none.fl_str_mv 2020-06-01T21:26:44Z
dc.date.available.none.fl_str_mv 2020-06-01T21:26:44Z
dc.date.issued.fl_str_mv 2017-06-06
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.citation.es_PE.fl_str_mv Hernández J., Montiel JL., De La Garza MA., Ruiz RV., Escamilla E., Guzman MA., et al. Subchronic infection of porphyromonas gingivalis and tannerella forsythia stimulates an Immune response but not arthritis in experimental murine model. Int J Dent. 2017; 2017: 2052938.
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12727/6136
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1155/2017/2052938
identifier_str_mv Hernández J., Montiel JL., De La Garza MA., Ruiz RV., Escamilla E., Guzman MA., et al. Subchronic infection of porphyromonas gingivalis and tannerella forsythia stimulates an Immune response but not arthritis in experimental murine model. Int J Dent. 2017; 2017: 2052938.
url https://hdl.handle.net/20.500.12727/6136
https://doi.org/10.1155/2017/2052938
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv urn:issn:2340-3152
dc.relation.ispartofseries.none.fl_str_mv International Journal of Dentistry;vol. 2017
dc.rights.es_PE.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.es_PE.fl_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
dc.format.extent.es_PE.fl_str_mv 2052938
dc.publisher.es_PE.fl_str_mv Hindawi
dc.publisher.country.es_PE.fl_str_mv GB
dc.source.es_PE.fl_str_mv Repositorio Académico USMP
Universidad de San Martín de Porres - USMP
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instname_str Universidad de San Martín de Porres
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spelling Hernández-Aguas, JordayMontiel-Hernández, José LuisDe La Garza-Ramos, Myriam A.Ruiz-Ramos, Rosa VeliaEscamilla García, ErandiGuzmán-García, Mario AlbertoAyón-Haro, Esperanza RaquelGarza-Elizondo, Mario Alberto2020-06-01T21:26:44Z2020-06-01T21:26:44Z2017-06-06Hernández J., Montiel JL., De La Garza MA., Ruiz RV., Escamilla E., Guzman MA., et al. Subchronic infection of porphyromonas gingivalis and tannerella forsythia stimulates an Immune response but not arthritis in experimental murine model. Int J Dent. 2017; 2017: 2052938.https://hdl.handle.net/20.500.12727/6136https://doi.org/10.1155/2017/2052938Studies have proposed that Porphyromonas gingivalis (Pg) and Tannerella forsythia (Tf) promote a nonspecific inflammatory response that could produce systemic disease. Oral inoculation of Pg and Tf on the immune and arthritis response was evaluated in BALB/C mice divided into four groups: (1) sham; (2) food contaminated with Pg/Tf; (3) complete Freund’s adjuvant (CFA) + Pg/Tf; and (4) CFA alone. CFA was administered subcutaneously on days 1 and 14. The arthritis response was monitored for 21 days after day 14 of CFA administration. IL-1β and IL-6 were determined in serum. T cell activation was evaluated by CD25 in salivary lymph nodes or mouse spleen. Pad inflammation appeared by day 19 in the CFA group, but animals with bacteria inoculation presented a delay. A significant increase in IL-6 was found in Groups 3 and 4, but not with respect to IL-1β. We observed an increase in CD25 in cells derived from cervical nodes and in animals with bacteria inoculation and CFA. A local immune response was observed in mice inoculated with Pg and Tf (T cell activation); a systemic response was observed with CFA. Since pad inflammation was delayed by bacterial inoculation this suggests that local T cell activation could decrease pad inflammation.ProyectoProinnova-CONACYT Steripharma, Grant no. 141616.2052938engHindawiGBurn:issn:2340-3152International Journal of Dentistry;vol. 2017info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/Repositorio Académico USMPUniversidad de San Martín de Porres - USMPreponame:USMP-Institucionalinstname:Universidad de San Martín de Porresinstacron:USMPInfeccionesPorphyromonas gingivalisTannerella forsythiaArtritis reumatoidehttps://purl.org/pe-repo/ocde/ford#3.02.00Subchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine modelinfo:eu-repo/semantics/articleMedicina HumanaUniversidad de San Martín de Porres. 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