Predictor factors for multidrug-resistant tuberculosis among patients with pulmonary tuberculosis in Huánuco, Peru. 2010-2015: Predictores clínicos de tuberculosis multidrogorresistente en pacientes con tuberculosis pulmonar en Huánuco, Perú. 2010-2015

• Autores: Valdivia-Gómez, Anghella, Zavala-Lazo, Noelia, Dámaso-Mata, Bernardo, Panduro-Correa, Vicky, Segama-Fabian, Edinho, Arteaga-Livias, Kovy
• Formato: artículo
• Fecha de Publicación: 2020
• Institución: Universidad Ricardo Palma
• Repositorio: Revistas - Universidad Ricardo Palma
• Lenguaje: español; inglés
• OAI Identifier: oai:oai.revistas.urp.edu.pe:article/2711
• Enlace del recurso: http://revistas.urp.edu.pe/index.php/RFMH/article/view/2711
• Nivel de acceso: acceso abierto

Introduction: In the city of Huánuco and around the world, there is a progressive increase in cases of Tuberculosis and multidrug-resistant Tuberculosis, for this reason it was necessary to identify predictors to develop multidrug-resistant Tuberculosis. Objective: To determine if persistent fever, cavitary radiographic pattern and positive smear microscopy at the first month of treatment, are predictors of multidrug-resistant Tuberculosis in patients with Pulmonary Tuberculosis, in four health facilities in the city of Huánuco, between January 2010 and December 2015. Methods: case and control study. We considered 37 cases and 111 controls. Data were collected from medical records. Results: The predictive factors found in the bivariate analysis were persistence of fever at 2 weeks (p = 0.001, OR 0.05, CI 0.01-0.5), cavitary radiographic pattern (p = 0.000, OR 11.6, 95%IC 4.6-26.5), and smear microscopy positivity at the first month of treatment (p = 0.00, OR 13.5, 95%CI 4.1-44.6). These were confirmed by multivariate analysis (p = 0.012, p = 0.00, p = 0.00 respectively). Conclusions: The persistence of fever at two weeks, cavitary radiographic pattern and positive smear microscopy at the first month of treatment were predictive factors associated independently for the diagnosis of multidrug-resistant Tuberculosis.