Advances in translational medicine for the management of melanoma: A narrative review: Avances en medicina traslacional para el manejo del melanoma: Una revisión narrativa

• Autores: Arenas-Sánchez, Kelly Andrea, Perdomo-Farelo, Luis David, Tovar-Mera, Andrea, Gómez-Gallego, Ana María, Vieira-Rios, Sara María, Solarte-Encarnación, Angelly, Serna-Trejos, Juan Santiago
• Formato: artículo
• Fecha de Publicación: 2025
• Institución: Universidad de Ciencias y Humanidades
• Repositorio: Health care & global health
• Lenguaje: español
• OAI Identifier: oai:ojs.openhgh.org:article/337
• Enlace del recurso: http://revista.uch.edu.pe/index.php/hgh/article/view/337
• Nivel de acceso: acceso abierto

Introduction: Melanoma is a highly immunogenic neoplasm whose treatment has evolved with the development of innovative immunotherapeutic strategies. Objective: To analyze advances in immunotherapy and translational medicine for the treatment of melanoma, highlighting new therapies and their impact on clinical practice. Methodology: A narrative review was carried out in scientific databases, including Medline, PubMed, EMBASE, Cochrane Library, OVID and ClinicalKey. Articles were taken in English and Spanish, without time restriction. Relevant studies on immunotherapy, cell therapy, oncolytic viruses and personalized vaccines were selected. Results: The combination of immune checkpoint inhibitors with emerging therapies has improved tumor response and survival. However, tumor heterogeneity and immunosuppression of the microenvironment remain challenges. Conclusion: Translational medicine is key to optimizing melanoma treatment. Interdisciplinary research and biomarker development will allow more effective and personalized therapies, improving clinical outcomes in this pathology. Keywords: Melanoma; Neoplasms; Nevi and Melanomas; Skin Neoplasms;  Neuroendocrine Tumors; Therapeutics; Translational Science, Biomedical (Source: MeSH, NLM).