Potential effect of ibuprofen and celecoxib on fertility in female rats

• Autores: Flores-Cortez, Daisy, Bacalla-Gabriel, Leidy Stefanie, Osorio-Tarrillo, Milagros, Rodriguez-Tafur, Juan, Villalobos-Pacheco, Eduardo
• Formato: artículo
• Fecha de Publicación: 2022
• Institución: Sociedad Materno Fetal
• Repositorio: Revista Internacional de Salud Materno Fetal
• Lenguaje: español
• OAI Identifier: oai:ojs2.ojs.revistamaternofetal.com:article/100
• Enlace del recurso: http://ojs.revistamaternofetal.com/index.php/RISMF/article/view/100
• Nivel de acceso: acceso abierto
• Materia: Celecoxib; Ibuprofeno; Ratas; Fertilidad

Objective: To evaluate the effect of Ibuprofen and Celecoxib on fertility in female rats. Material and methods: 22 14-week-old Holtzman female rats were selected, which were in the diestrus stage, determined by vaginal cytology evaluation, who were distributed into three groups, and treated orally for two days, as follows: Group control: physiological saline 1 ml/100g, experimental group 1: Ibuprofen 120 mg/kg/day and experimental group 2: Celecoxib 20 mg/kg/day. After two days they were mated with the males, until the end of the next estrous cycle. The rats were euthanized 10 days after separation from the male and the presence and number of implanted embryos were evaluated. Results: The percentage of rats that did not present pregnancy was 14.3, 71.4 and 37.5% in the control, Ibuprofen and Celecoxib groups respectively; while the average number of embryos implanted were: control group 8.4, Ibuprofen 2.0 and Celecoxib 3.3. The proportion of fertility inhibition was 76.3% for the Ibuprofen group and 60% for Celecoxib. Conclusion: It is concluded that both Celecoxib and Ibuprofen decrease fertility in rats.