Guía de práctica clínica para el manejo del episodio depresivo moderado y episodio depresivo severo sin síntomas psicóticos en el Seguro Social de Salud (EsSalud)

• Autores: Gavilán-Villanueva, José Luis, Brañez-Condorena, Ana, Fernández-Infante, Omar, Quispe-Baltazar, Patricia Roxana Zarela, Castro-Moscoso, Andrea Paola, Aybar-Cachay, Nery Ricardo, Caycho-Solís, Jessica Gisela, Tipacti-Tafur, Rina Roxina, Nateros, Fernando, Rivera-Torrejón, Oscar, Taype-Rondan, Álvaro, Salvador-Salvador, Stefany, Santos-Sánchez, Vladimir
• Formato: artículo
• Fecha de Publicación: 2025
• Institución: Colegio Médico del Perú
• Repositorio: Acta Médica Peruana
• Lenguaje: español
• OAI Identifier: oai:amp.cmp.org.pe:article/3593
• Enlace del recurso: https://amp.cmp.org.pe/index.php/AMP/article/view/3593
• Nivel de acceso: acceso abierto
• Materia: Depresión; Trastorno Depresivo; Garantía de la Calidad de Atención de Salud; Enfoque GRADE; Medicina Basada en Evidencias; Depression; Depressive Disorder; Quality Assurance, Health Care; GRADE Approach; Evidence-Based Medicine

This article resumes the Clinical Practice Guideline (CPG) for the management of moderate to severe depressive episodes without psychotic symptoms in the Peruvian Social Health Insurance (EsSalud). The CGP’s aim is to provide evidence based recommendations for the clinical evaluation and treatment of these patients. In order to develop this guideline, a multidisciplinary Guideline Development Group (GDG)—including medical specialists and methodologists—was established. The GDG formulated key clinical questions to guide the evidence review. Multiple systematic literature searches were conducted for each clinical question during 2023. The GRADE methodology (Grading of Recommendations Assessment, Development, and Evaluation) was used to assess the certainty of the evidence and support the formulation of recommendations. The final CPG includes seven clinical questions across two domains: pharmacological and non-pharmacological management. It includes nine conditional recommendations, thirty good clinical practice statements, and three care flowcharts.