Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

• Autores: Tauchen, Jan, Bortl, Ludvik, Huml, Lukas, Miksatkova, Petra, Doskocil, Ivo, Marsik, Petr, Panduro Villegas, Pablo Pedro, Bendezu Flores, Ymber, Van Damme, Patrick, Lojka, Bohdan, Havlik, Jaroslav, Lapcik, Oldrich, Kokoska, Ladislav
• Formato: artículo
• Fecha de Publicación: 2016
• Institución: Instituto Nacional de Innovación Agraria
• Repositorio: INIA-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:null:20.500.12955/1143
• Enlace del recurso: https://repositorio.inia.gob.pe/handle/20.500.12955/1143; http://dx.doi.org/10.1016/j.bjp.2016.03.016
• Nivel de acceso: acceso abierto
• Materia: Antioxidant; Anticarcinogenic; Phenolic compounds; Plant extracts; Biotecnología agrícola, Biotecnología alimentaria

Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 ± 51.4 μg TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 μg/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 μg TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 μg/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 μg TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 μg/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.