Biomarkers of human papillomavirus (HPV)-driven head and neck cancer in Latin America and Europe study: Study design and HPV DNA/p16(INK4a) status

• Autores: Sichero, L, Tagliabue, M, Mota, G, Ferreira, S, Nunes, RAL, Castañeda, CA, Castillo, M, Correa, RM, Perdomo, S, Rodríguez-Urrego, PA, Matos, LL, Mohssen, A, Gheit, T, Tommasino, M, Chiocca, S, Villa, LL, HEADLAcE Study Group.
• Formato: artículo
• Fecha de Publicación: 2022
• Institución: Instituto Nacional de Enfermedades Neoplásicas
• Repositorio: INEN-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.inen.sld.pe:inen/58
• Enlace del recurso: https://repositorio.inen.sld.pe/handle/inen/58
• Nivel de acceso: acceso abierto
• Materia: Dspace; Open access; Repositorio digital; https://purl.org/pe-repo/ocde/ford#3.02.21

Background: Human papillomavirus (HPV)-driven head/neck squamous cell carcinomas (HNSCC) prevalence varies globally. We evaluated HPV DNA and p16INK4a in formalin fixed paraffin embedded (FFPE) HNSCC from Argentina, Brazil, Colombia, and Peru. Methods: HPV was genotyped by PCR-hybridization. All HPV DNA positive and some HPV DNA negative cases underwent p16INK4a immunohistochemistry. Results: HPV DNA was detected in 32.8%, 11.1%, and 17.8% of oropharyngeal (OPC), oral cavity (OCC) and laryngeal (LC) cancers, respectively. OPC HPV prevalence was higher in Colombia (94.7%), and Argentina (42.6%) compared to Brazil (10.6%) and Peru (0.0%). HPV-16 was the most detected. Other HPVs were found in LC. Higher rates of p16INK4a positivity were observed among HPV positive OPC/OCC cases compared to LC cases. Conclusions: Our results support a role for HPV-16 in a subset of HNSCC, corroborate the heterogeneity observed in samples from different countries, and contribute additional etiological and biomarkers information in tumors of significant impact worldwide. Keywords: head and neck cancer; human papillomavirus; multinational study; prevalence; risk factors.