Parasite antigen in serum predicts the presence of viable brain parasites in patients with apparently calcified cysticercosis only.

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Estudio que evalúa si los exámenes de ELISA (enzyme-linked immunosorbent assay) y Ag-ELISA (antigen detection) predicen quistes viables en pacientes con lesiones calcificadas en el cerebro no detectados en tomografía computarizada. Se procesaron con Ag-ELISA y con inmunoelectrotransferencia enzimáti...

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Detalles Bibliográficos
Autores: Zea-Vera, Alonso, Cordova, Erika G., Rodriguez, Silvia, Gonzales, Isidro, Pretell, Edwin Javier, Castillo, Yesenia, Castro-Suarez, Sheila, Gabriel, Sarah, Tsang, Victor C. W., Dorny, Pierre, Garcia, Hector H.
Formato: artículo
Fecha de Publicación:2013
Institución:Seguro Social de Salud
Repositorio:ESSALUD-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.essalud.gob.pe:20.500.12959/549
Enlace del recurso:https://hdl.handle.net/20.500.12959/549
https://doi.org/10.1093/cid/cit422
Nivel de acceso:acceso abierto
Materia:Parasitología
Neurocisticercosis
Técnicas y procedimientos diagnósticos
Neurocysticercosis
Antigen detection
Calcifications
Epilepsy
https://purl.org/pe-repo/ocde/ford#3.03.05
https://purl.org/pe-repo/ocde/ford#3.03.02
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network_acronym_str ESSA
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dc.title.es_PE.fl_str_mv Parasite antigen in serum predicts the presence of viable brain parasites in patients with apparently calcified cysticercosis only.
title Parasite antigen in serum predicts the presence of viable brain parasites in patients with apparently calcified cysticercosis only.
spellingShingle Parasite antigen in serum predicts the presence of viable brain parasites in patients with apparently calcified cysticercosis only.
Zea-Vera, Alonso
Parasitología
Neurocisticercosis
Técnicas y procedimientos diagnósticos
Neurocysticercosis
Antigen detection
Calcifications
Epilepsy
https://purl.org/pe-repo/ocde/ford#3.03.05
https://purl.org/pe-repo/ocde/ford#3.03.02
title_short Parasite antigen in serum predicts the presence of viable brain parasites in patients with apparently calcified cysticercosis only.
title_full Parasite antigen in serum predicts the presence of viable brain parasites in patients with apparently calcified cysticercosis only.
title_fullStr Parasite antigen in serum predicts the presence of viable brain parasites in patients with apparently calcified cysticercosis only.
title_full_unstemmed Parasite antigen in serum predicts the presence of viable brain parasites in patients with apparently calcified cysticercosis only.
title_sort Parasite antigen in serum predicts the presence of viable brain parasites in patients with apparently calcified cysticercosis only.
author Zea-Vera, Alonso
author_facet Zea-Vera, Alonso
Cordova, Erika G.
Rodriguez, Silvia
Gonzales, Isidro
Pretell, Edwin Javier
Castillo, Yesenia
Castro-Suarez, Sheila
Gabriel, Sarah
Tsang, Victor C. W.
Dorny, Pierre
Garcia, Hector H.
author_role author
author2 Cordova, Erika G.
Rodriguez, Silvia
Gonzales, Isidro
Pretell, Edwin Javier
Castillo, Yesenia
Castro-Suarez, Sheila
Gabriel, Sarah
Tsang, Victor C. W.
Dorny, Pierre
Garcia, Hector H.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Zea-Vera, Alonso
Cordova, Erika G.
Rodriguez, Silvia
Gonzales, Isidro
Pretell, Edwin Javier
Castillo, Yesenia
Castro-Suarez, Sheila
Gabriel, Sarah
Tsang, Victor C. W.
Dorny, Pierre
Garcia, Hector H.
dc.subject.es_PE.fl_str_mv Parasitología
Neurocisticercosis
Técnicas y procedimientos diagnósticos
topic Parasitología
Neurocisticercosis
Técnicas y procedimientos diagnósticos
Neurocysticercosis
Antigen detection
Calcifications
Epilepsy
https://purl.org/pe-repo/ocde/ford#3.03.05
https://purl.org/pe-repo/ocde/ford#3.03.02
dc.subject.none.fl_str_mv Neurocysticercosis
Antigen detection
Calcifications
Epilepsy
dc.subject.ocde.es_PE.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.03.05
https://purl.org/pe-repo/ocde/ford#3.03.02
description Estudio que evalúa si los exámenes de ELISA (enzyme-linked immunosorbent assay) y Ag-ELISA (antigen detection) predicen quistes viables en pacientes con lesiones calcificadas en el cerebro no detectados en tomografía computarizada. Se procesaron con Ag-ELISA y con inmunoelectrotransferencia enzimática, muestras de suero de 39 pacientes con neurocisticercosis calcificada y parásitos no viables en tomografía computarizada; se realizó resonancia magnética a cada paciente con dos meses de prueba serológica. Se concluye que la detección de antígenos y un grado menor de reacciones a anticuerpos pueden predecir neurocisticercosis viable. Los métodos de diagnóstico serológico podrían identificar lesiones viables no encontradas por tomografía computarizada, en pacientes con aparentemente sólo cisticercosis calcificada.
publishDate 2013
dc.date.accessioned.none.fl_str_mv 2019-05-17T21:01:14Z
dc.date.available.none.fl_str_mv 2019-05-17T21:01:14Z
dc.date.issued.fl_str_mv 2013-06
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.citation.es_PE.fl_str_mv Clinical Infectious Diseases. 2013; 57 (7)
dc.identifier.issn.none.fl_str_mv 1058-4838
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12959/549
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1093/cid/cit422
identifier_str_mv Clinical Infectious Diseases. 2013; 57 (7)
1058-4838
url https://hdl.handle.net/20.500.12959/549
https://doi.org/10.1093/cid/cit422
dc.language.iso.es_PE.fl_str_mv eng
language eng
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dc.rights.es_PE.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.es_PE.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.es_PE.fl_str_mv application/pdf
dc.publisher.es_PE.fl_str_mv Infectious Diseases Sociedty of America
dc.publisher.country.es_PE.fl_str_mv PE
dc.source.es_PE.fl_str_mv Seguro Social de Salud (EsSalud)
Repositorio Institucional EsSalud
dc.source.none.fl_str_mv reponame:ESSALUD-Institucional
instname:Seguro Social de Salud
instacron:ESSALUD
instname_str Seguro Social de Salud
instacron_str ESSALUD
institution ESSALUD
reponame_str ESSALUD-Institucional
collection ESSALUD-Institucional
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spelling Zea-Vera, AlonsoCordova, Erika G.Rodriguez, SilviaGonzales, IsidroPretell, Edwin JavierCastillo, YeseniaCastro-Suarez, SheilaGabriel, SarahTsang, Victor C. W.Dorny, PierreGarcia, Hector H.2019-05-17T21:01:14Z2019-05-17T21:01:14Z2013-06Clinical Infectious Diseases. 2013; 57 (7)1058-4838https://hdl.handle.net/20.500.12959/549https://doi.org/10.1093/cid/cit422Estudio que evalúa si los exámenes de ELISA (enzyme-linked immunosorbent assay) y Ag-ELISA (antigen detection) predicen quistes viables en pacientes con lesiones calcificadas en el cerebro no detectados en tomografía computarizada. Se procesaron con Ag-ELISA y con inmunoelectrotransferencia enzimática, muestras de suero de 39 pacientes con neurocisticercosis calcificada y parásitos no viables en tomografía computarizada; se realizó resonancia magnética a cada paciente con dos meses de prueba serológica. Se concluye que la detección de antígenos y un grado menor de reacciones a anticuerpos pueden predecir neurocisticercosis viable. Los métodos de diagnóstico serológico podrían identificar lesiones viables no encontradas por tomografía computarizada, en pacientes con aparentemente sólo cisticercosis calcificada.Background. Computed tomography (CT) remains the standard neuroimaging screening exam for neurocysticercosis, and residual brain calcifications are the commonest finding. Magnetic resonance imaging (MRI) is more sensitive than CT but is rarely available in endemic regions. Enzyme-linked immunoelectrotransfer blot (EITB) assay uses antibody detection for diagnosis confirmation; by contrast, enzyme-linked immunosorbent assay (ELISA) antigen detection (Ag-ELISA) detects circulating parasite antigen. This study evaluated whether these assays predict undetected viable cysts in patients with only calcified lesions on brain CT. Methods. Serum samples from 39 patients with calcified neurocysticercosis and no viable parasites on CT were processed by Ag-ELISA and EITB. MRI was performed for each patient within 2 months of serologic testing. Conservatively high ELISA and EITB cutoffs were used to predict the finding of viable brain cysts on MRI. Results. Using receiver operating characteristic–optimized cutoffs, 7 patients were Ag-ELISA positive, and 8 had strong antibody reactions on EITB. MRI showed viable brain cysts in 7 (18.0%) patients. Patients with positive Ag-ELISA were more likely to have viable cysts than Ag-ELISA negatives (6/7 vs 1/32; odds ratio, 186 [95% confidence interval, 1–34 470.0], P < .001; sensitivity 85.7%, specificity 96.9%, positive likelihood ratio of 27 to detect viable cysts). Similar but weaker associations were also found between a strong antibody reaction on EITB and undetected viable brain cysts. Conclusions. Antigen detection, and in a lesser degree strong antibody reactions, can predict viable neurocysticercosis. Serological diagnostic methods could identify viable lesions missed by CT in patients with apparently only calcified cysticercosis and could be considered for diagnosis workup and further therapy.application/pdfengInfectious Diseases Sociedty of AmericaPEhttps://academic.oup.com/cid/article/57/7/e154/337081?login=falseinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/Seguro Social de Salud (EsSalud)Repositorio Institucional EsSaludreponame:ESSALUD-Institucionalinstname:Seguro Social de Saludinstacron:ESSALUDParasitologíaNeurocisticercosisTécnicas y procedimientos diagnósticosNeurocysticercosisAntigen detectionCalcificationsEpilepsyhttps://purl.org/pe-repo/ocde/ford#3.03.05https://purl.org/pe-repo/ocde/ford#3.03.02Parasite antigen in serum predicts the presence of viable brain parasites in patients with apparently calcified cysticercosis only.info:eu-repo/semantics/articleORIGINALParasite antigen in serum predicts the presence of viable brain parasites.pdfParasite antigen in serum predicts the presence of viable brain parasites.pdfapplication/pdf533558https://repositorio.essalud.gob.pe/bitstream/20.500.12959/549/1/Parasite%20antigen%20in%20serum%20predicts%20the%20presence%20of%20viable%20brain%20parasites.pdff0e16ed7b043b47d446edc352d8d46a1MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.essalud.gob.pe/bitstream/20.500.12959/549/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTParasite antigen in serum predicts the presence of viable brain parasites.pdf.txtParasite antigen in serum predicts the presence of viable brain parasites.pdf.txtExtracted texttext/plain26654https://repositorio.essalud.gob.pe/bitstream/20.500.12959/549/3/Parasite%20antigen%20in%20serum%20predicts%20the%20presence%20of%20viable%20brain%20parasites.pdf.txtdbf36a917f2bff3654aa48ff17c9be08MD53THUMBNAILParasite antigen in serum predicts the presence of viable brain parasites.pdf.jpgParasite antigen in serum predicts the presence of viable brain parasites.pdf.jpgGenerated Thumbnailimage/jpeg7468https://repositorio.essalud.gob.pe/bitstream/20.500.12959/549/4/Parasite%20antigen%20in%20serum%20predicts%20the%20presence%20of%20viable%20brain%20parasites.pdf.jpga51f5c0be16a83d4a1398c60587c397aMD5420.500.12959/549oai:repositorio.essalud.gob.pe:20.500.12959/5492023-07-31 01:19:34.261Repositorio Seguro Social de Salud – ESSALUDbibliotecacentral@essalud.gob.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Parasite antigen in serum predicts the presence of viable brain parasites in patients with apparently calcified cysticercosis only.
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