Neuroprotective effect of sacha inchi oil (Plukenetia volubilis L.) in an experimental model of epilepsy
Descripción del Articulo
The authors thank Universidad Nacional Mayor de San Marcos for helping to support this research. Cesar Franco-Quino is a doctoral student studying an Epidemiological Researcher Doctorate at Universidad Peruana Cayetano Heredia under FONDECYT/ CIENCIAACTIVA scholarship EF033-235-2015 and supported by...
| Autores: | , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2019 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/2746 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/2746 https://doi.org/10.5530/PJ.2019.11.243 |
| Nivel de acceso: | acceso abierto |
| Materia: | Sacha inchi Convulsion Epilepsy Omega Pentylenetetrazole Plukenetia volubilis http://purl.org/pe-repo/ocde/ford#3.01.04 |
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CONCYTEC-Institucional |
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4689 |
| dc.title.none.fl_str_mv |
Neuroprotective effect of sacha inchi oil (Plukenetia volubilis L.) in an experimental model of epilepsy |
| title |
Neuroprotective effect of sacha inchi oil (Plukenetia volubilis L.) in an experimental model of epilepsy |
| spellingShingle |
Neuroprotective effect of sacha inchi oil (Plukenetia volubilis L.) in an experimental model of epilepsy Herrera-Calderon, Oscar Sacha inchi Convulsion Epilepsy Omega Pentylenetetrazole Plukenetia volubilis http://purl.org/pe-repo/ocde/ford#3.01.04 |
| title_short |
Neuroprotective effect of sacha inchi oil (Plukenetia volubilis L.) in an experimental model of epilepsy |
| title_full |
Neuroprotective effect of sacha inchi oil (Plukenetia volubilis L.) in an experimental model of epilepsy |
| title_fullStr |
Neuroprotective effect of sacha inchi oil (Plukenetia volubilis L.) in an experimental model of epilepsy |
| title_full_unstemmed |
Neuroprotective effect of sacha inchi oil (Plukenetia volubilis L.) in an experimental model of epilepsy |
| title_sort |
Neuroprotective effect of sacha inchi oil (Plukenetia volubilis L.) in an experimental model of epilepsy |
| author |
Herrera-Calderon, Oscar |
| author_facet |
Herrera-Calderon, Oscar Yuli-Posadas, Ricado Ángel Tinco-Jayo, Johnny Aldo Enciso-Roca, Edwin Franco-Quino, César Chumpitaz-Cerrate, Victor Figueroa-Salvador, Linder |
| author_role |
author |
| author2 |
Yuli-Posadas, Ricado Ángel Tinco-Jayo, Johnny Aldo Enciso-Roca, Edwin Franco-Quino, César Chumpitaz-Cerrate, Victor Figueroa-Salvador, Linder |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Herrera-Calderon, Oscar Yuli-Posadas, Ricado Ángel Tinco-Jayo, Johnny Aldo Enciso-Roca, Edwin Franco-Quino, César Chumpitaz-Cerrate, Victor Figueroa-Salvador, Linder |
| dc.subject.none.fl_str_mv |
Sacha inchi |
| topic |
Sacha inchi Convulsion Epilepsy Omega Pentylenetetrazole Plukenetia volubilis http://purl.org/pe-repo/ocde/ford#3.01.04 |
| dc.subject.es_PE.fl_str_mv |
Convulsion Epilepsy Omega Pentylenetetrazole Plukenetia volubilis |
| dc.subject.ocde.none.fl_str_mv |
http://purl.org/pe-repo/ocde/ford#3.01.04 |
| description |
The authors thank Universidad Nacional Mayor de San Marcos for helping to support this research. Cesar Franco-Quino is a doctoral student studying an Epidemiological Researcher Doctorate at Universidad Peruana Cayetano Heredia under FONDECYT/ CIENCIAACTIVA scholarship EF033-235-2015 and supported by training grant D43 TW007393 awarded by Fogarti International Center of the US National Institutes of Health. |
| publishDate |
2019 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/2746 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.5530/PJ.2019.11.243 |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-85077326578 |
| url |
https://hdl.handle.net/20.500.12390/2746 https://doi.org/10.5530/PJ.2019.11.243 |
| identifier_str_mv |
2-s2.0-85077326578 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Pharmacognosy Journal |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
| dc.publisher.none.fl_str_mv |
EManuscript Technologies |
| publisher.none.fl_str_mv |
EManuscript Technologies |
| dc.source.none.fl_str_mv |
reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
| instname_str |
Consejo Nacional de Ciencia Tecnología e Innovación |
| instacron_str |
CONCYTEC |
| institution |
CONCYTEC |
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CONCYTEC-Institucional |
| collection |
CONCYTEC-Institucional |
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Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1839175800676417536 |
| spelling |
Publicationrp07349600rp07348600rp07353600rp07346600rp07347600rp07352600rp07358600Herrera-Calderon, OscarYuli-Posadas, Ricado ÁngelTinco-Jayo, Johnny AldoEnciso-Roca, EdwinFranco-Quino, CésarChumpitaz-Cerrate, VictorFigueroa-Salvador, Linder2024-05-30T23:13:38Z2024-05-30T23:13:38Z2019https://hdl.handle.net/20.500.12390/2746https://doi.org/10.5530/PJ.2019.11.2432-s2.0-85077326578The authors thank Universidad Nacional Mayor de San Marcos for helping to support this research. Cesar Franco-Quino is a doctoral student studying an Epidemiological Researcher Doctorate at Universidad Peruana Cayetano Heredia under FONDECYT/ CIENCIAACTIVA scholarship EF033-235-2015 and supported by training grant D43 TW007393 awarded by Fogarti International Center of the US National Institutes of Health.Background: Experimental studies have demonstrated that fatty acids such as omega 3 and 6 have anti-inflammatory, anticonvulsant, cardio protective and anti-tumor effects. Objective:The main objective was to determine the protective effect of sacha inchi oil on pentylenetetrazole-induced seizures in albino mice. Material and Methods: Thirty male Balb/C albino mice of 8 weeks of age were purchased from the National Institute of Health (Lima-Peru). The animals were divided into 5 groups of 6 animals each one. Group I: Control; PTZ (pentylenetetrazole 80 mg / kg, s.c.). II: PTZ + Diazepam (1 mg / kg; s.c.). Group III, IV, V: PTZ + sacha inchi oil at single doses of 250, 500, 1000 mg / kg respectively orally. Sacha inchi oil was administered 30 minutes before induction of seizures by PTZ. Next, various parameters such as latency, seizure frequency, duration and score were scored according to Racine scale. The program Graph Pad Prism v.4 was used for statistical analysis. Results: As result, the experimental group treated with sacha inchi oil at maximum dose of 1000 mg/kg showed better results in response to PTZ induced seizure; low levels of seizures, frequency and duration (P<0.001; ANOVA, P <0.001 Post-hoc Dunnett test). Conclusion: It is concluded that Sacha inchi oil presented anticonvulsant effect at the highest doses tested being very similar to Diazepam. The main mechanism could be by reducing free radical and improving GABA levels in the brain. © 2019 Phcogj.Com.Fondo Nacional de Desarrollo Científico y Tecnológico - FondecytengEManuscript TechnologiesPharmacognosy Journalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/Sacha inchiConvulsion-1Epilepsy-1Omega-1Pentylenetetrazole-1Plukenetia volubilis-1http://purl.org/pe-repo/ocde/ford#3.01.04-1Neuroprotective effect of sacha inchi oil (Plukenetia volubilis L.) in an experimental model of epilepsyinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#20.500.12390/2746oai:repositorio.concytec.gob.pe:20.500.12390/27462024-05-30 15:25:27.884https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="e8496063-d20c-455d-baf2-cdcd7e299121"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Neuroprotective effect of sacha inchi oil (Plukenetia volubilis L.) in an experimental model of epilepsy</Title> <PublishedIn> <Publication> <Title>Pharmacognosy Journal</Title> </Publication> </PublishedIn> <PublicationDate>2019</PublicationDate> <DOI>https://doi.org/10.5530/PJ.2019.11.243</DOI> <SCP-Number>2-s2.0-85077326578</SCP-Number> <Authors> <Author> <DisplayName>Herrera-Calderon, Oscar</DisplayName> <Person id="rp07349" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Yuli-Posadas, Ricado Ángel</DisplayName> <Person id="rp07348" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Tinco-Jayo, Johnny Aldo</DisplayName> <Person id="rp07353" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Enciso-Roca, Edwin</DisplayName> <Person id="rp07346" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Franco-Quino, César</DisplayName> <Person id="rp07347" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Chumpitaz-Cerrate, Victor</DisplayName> <Person id="rp07352" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Figueroa-Salvador, Linder</DisplayName> <Person id="rp07358" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>EManuscript Technologies</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by/4.0/</License> <Keyword>Sacha inchi</Keyword> <Keyword>Convulsion</Keyword> <Keyword>Epilepsy</Keyword> <Keyword>Omega</Keyword> <Keyword>Pentylenetetrazole</Keyword> <Keyword>Plukenetia volubilis</Keyword> <Abstract>Background: Experimental studies have demonstrated that fatty acids such as omega 3 and 6 have anti-inflammatory, anticonvulsant, cardio protective and anti-tumor effects. Objective:The main objective was to determine the protective effect of sacha inchi oil on pentylenetetrazole-induced seizures in albino mice. Material and Methods: Thirty male Balb/C albino mice of 8 weeks of age were purchased from the National Institute of Health (Lima-Peru). The animals were divided into 5 groups of 6 animals each one. Group I: Control; PTZ (pentylenetetrazole 80 mg / kg, s.c.). II: PTZ + Diazepam (1 mg / kg; s.c.). Group III, IV, V: PTZ + sacha inchi oil at single doses of 250, 500, 1000 mg / kg respectively orally. Sacha inchi oil was administered 30 minutes before induction of seizures by PTZ. Next, various parameters such as latency, seizure frequency, duration and score were scored according to Racine scale. The program Graph Pad Prism v.4 was used for statistical analysis. Results: As result, the experimental group treated with sacha inchi oil at maximum dose of 1000 mg/kg showed better results in response to PTZ induced seizure; low levels of seizures, frequency and duration (P<0.001; ANOVA, P <0.001 Post-hoc Dunnett test). Conclusion: It is concluded that Sacha inchi oil presented anticonvulsant effect at the highest doses tested being very similar to Diazepam. The main mechanism could be by reducing free radical and improving GABA levels in the brain. © 2019 Phcogj.Com.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
| score |
13.210282 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
