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La endometritis, inflamación del endometrio usualmente debido a la persistencia de una infección o al retraso en la involución uterina, es uno de los principales factores que afectan la eficiencia reproductiva del vacuno lechero retrasando el retorno de la vaca en sus actividades reproductivas. En ausencia de signos clínicos de endometritis, las modificaciones del endometrio uterino pueden ser definidas como endometritis subclínicas (ES) que se caracterizan por la presencia y aumento de Polimorfo Nucleares Neutrófilos (PMN) en el lumen uterino sin descargas purulentas.

Lepidium meyenii (Maca) is a native resource of the central Andes of Peru that has achieved international importance due to its medicinal properties. The main active components presents in this plant are the macamides, secondary amides formed by benzylamine and a rest of fatty acid, with variable lengths of chain and degree of unsaturation. In the present work were identified and quantified by HPLC-DAD, N (3 metoxibenzyl)-tetradecanamide(1), Nbenzylhexadecanamide(2), N-(3-metoxibenzyl) hexadecanamide(3), N-benzyl-octadecanamide(5), N-benzyltetracosanamide(11); present in the pentanic extracts obtained by liquid-liquid continuous partition of methanolic extracts of yellow, black and red ecotypes. It was required a process of adaptation and standardization of the chromatographic analytical technique using a stationary C-18 and a mobile phase composed of acetonitrile and water acidified app...

This study was supported by the Consejo Nacional de Ciencia, Tecnologia e Innovacion y Tecnologia (CONCYTEC) and the Fondo Nacional de Desarrollo Cientifico, Tecnologico y de Innovacion Tecnologica de Peru (FONDECYT). Contract Nr. 24-2019. We would like to thank Dr. Maximo Rondon and Dra Karina Rosas and theVicerrectorado de investigacion for providing substantial support to the Laboratory of Genomics and Neurovascular Diseases to carry out this work.

This research was funded by Consejo Nacional de Ciencia, Tecnologia e Innovacion Tecnologica de Peru (grant N~ 024-2019-Fondecyt-BM-INC.INV and CONCYTEC-FONDECYT-E038-01).