La formación de depósitos de placas de proteína C-amiloide (Aβ) en el cerebro, pueden evocar la muerte de las células neuronales y perjudicar la comunicación inter neuronal. La formación de dichas placas o simplemente el estrés generado por esta sustancia en las líneas celulares, puede desencadenar diferentes respuestas inmunitarias y moleculares por parte de nuestras células. Producción de Oxido Nítrico, Anion Superóxido y otras especies reactivas de oxigeno (ROS) son respuesta inmunitaria de un organismo. Sin embargo, estas respuestas y otras están mediadas exclusivamente por nuestro material genético. La expresión genética se puede ver alterada cuando existe de por medio un agente estresante. En el presente estudio se ha analizado la expresión genética de APP, BACE1 y PSEN1 en células SH-SY5Y, cuando estas células son sometidas a estrés por β-Amiloide. Se cultiv...

Lepidium meyenii (Maca) is a native resource of the central Andes of Peru that has achieved international importance due to its medicinal properties. The main active components presents in this plant are the macamides, secondary amides formed by benzylamine and a rest of fatty acid, with variable lengths of chain and degree of unsaturation. In the present work were identified and quantified by HPLC-DAD, N (3 metoxibenzyl)-tetradecanamide(1), Nbenzylhexadecanamide(2), N-(3-metoxibenzyl) hexadecanamide(3), N-benzyl-octadecanamide(5), N-benzyltetracosanamide(11); present in the pentanic extracts obtained by liquid-liquid continuous partition of methanolic extracts of yellow, black and red ecotypes. It was required a process of adaptation and standardization of the chromatographic analytical technique using a stationary C-18 and a mobile phase composed of acetonitrile and water acidified app...

The cation exchange capacity (CEC) of soil is an important parameter since it is an indicator of the fertility and physicochemical quality of the soil. There are several methods to find and estimate the CEC of soils. This work aims to compare the direct ammonium distillation method and the exchangeable base summation method based on the analysis of 65 samples taken from 0 to 0.20 m depth of soils in the northern and western areas of Honduras. Initially, the analyses of pH, % organic matter, % clay, and exchangeable bases (Ca, Mg, K, and Na) extracted with ammonium acetate at pH 7.00 were carried out. In addition, they were determined by atomic absorption, exchangeable acidity (H and Al), extracted with 1N KCl determined by titration. Subsequently, the CEC was determined by direct method of soil washing and ammonium distillation. The data was subjected to Pearson correlation analysis and ...