Introducción: El plomo inhibe la síntesis del grupo hemo y en consecuencia de la hemoglobina. Objetivos: Evaluar la intoxicación plúmbica crónica y su relación con problemas de anemia en trabajadores de Siderperu. Población muestral: 50 trabajadores. Determinación de la plumbemia: Espectroscopia de absorción atómica con horno de grafito. Análisis de hemoglobina: colorimétrico para la determinación de hemoglobina como cianuro de hemiglobina en sangre. Resultados: En la correlación de los niveles de plumbemia y el tiempo de exposición de los trabajadores de Siderperu se muestra que no existe una correlación significativa entre la concentración de plomo en la sangre y el tiempo de exposición de los trabajadores. Respecto a la correlación de los niveles de plumbemia y el área de trabajo de los trabajadores el 34 % de la población de estudio labora en el área de proceso ...

Background: Genetic testing for hereditary cancers is inconsistently applied within the healthcare systems in Latin America. In Peru, the prevalence and spectrum of cancer-predisposing germline variants is thus poorly characterized. Purpose: To determine the spectrum and prevalence of cancer-predisposing germline variants and variants of uncertain significance (VUS) in high-risk individuals located in a Peruvian low-resource setting city. Methods: Individuals presenting clinical criteria for hereditary cancer syndromes or being unaffected with familial history of cancer were included in the study. Samples from a total of 84 individuals were subjected to a high-throughput DNA sequencing assay that targeted a panel of 94 cancer predisposition genes. The pathogenicity of detected germline variants was classified according to the established American College of Medical Genetics and Genomics ...

Background: Genetic testing for hereditary cancers is inconsistently applied within the healthcare systems in Latin America. In Peru, the prevalence and spectrum of cancer-predisposing germline variants is thus poorly characterized. Purpose: To determine the spectrum and prevalence of cancer-predisposing germline variants and variants of uncertain significance (VUS) in high-risk individuals located in a Peruvian low-resource setting city. Methods: Individuals presenting clinical criteria for hereditary cancer syndromes or being unaffected with familial history of cancer were included in the study. Samples from a total of 84 individuals were subjected to a high-throughput DNA sequencing assay that targeted a panel of 94 cancer predisposition genes. The pathogenicity of detected germline variants was classified according to the established American College of Medical Genetics and Genomics ...