Abstract Objectives: To determine correlation between hormone therapy and endometrial mucosa estrogen, progesterone receptors and endometrial histological pathology in postmenopausal women. Material and Methods: Forty postmenopausal women between 43 and 60 years old with climacteric syndrome received oral continuous 2 mg of 17 beta estradiol and 1 mg of noresthisterone acetate. Basal and 8 months post treatment edo metrial biopsies were processed for histopathologic and immune histochemical studies for estrogen and progesterone receptors. Results: Physiologic menopause occurred between 42 and 52 years old, average 46,4 years. Main climacteric symptoms on first consultation were arthralgia 90%, emotional lability 82,5%, dysparenta 75%, hot flashes 27,5% and relative urine incontinence 17,5%. Post treatment emotional lability was 7,5% arthralgia 5%, relative urine incontinence 5%, hot flas...

Objective: To determine both the prevalence and risk factors of cervical cancer and squamous intraepithelial lesions, with special attention on the preinvasive cervical disease treatment. Design: Prospective, descriptive, non randomized study. Materials and Methods: Study of 120 non randomly selected cases of cervical cytology during 2003, in women attended at Piedra Liza Health Center (San Juan de Lurigancho). In 49 cases, biopsy was performed to confirm both clinical and colposcopic findings. Results: From the 120 cytology cases, 14 (11,5%) were ASC, 67 (56%) L-SIL, 34 (29%) H-SIL, 3 (2,5%) squamous carcinoma, 2 (2%) adenocarcinoma. In the 49 biopsies, 12 cases were L-SIL, 32 H-SIL, 3 invasive squamous carcinoma, and 2 cervical adenocarcinoma, one in situ. Conclusions: Cytology results suggest that squamous intraepithelial lesions and cervical carcinoma have higher prevalence in this s...

Objective: To determine endometrial morphology and estrogen receptors expression changes in post menopausal women following oral soya treatment. Design: Descriptve, observational, longitudinal and prospective study. Setting: Pathology Institute, San Marcos National Major University. Patients: Twenty-two post menopausal women treated with soya. Interventions: Histological and immunohistochemical studies were done in endometrium aspiration biopsies before and after 6 months treatment with 60 g oral soya per day. Main outcome measures: Endometrium histology and estrogen and progesterone receptors expression changes. Results: Age ranged between 46 and 65 years, 53 years average. There was apparent vasomotor symptoms improvement. Endometrium before soya treatment was atrophic in 19 patients (86%) and inactive in 3 (14%). Following soya treatment 17 (77,3%) persisted atrophic, 4 (18,2%) were i...