The objective of the study was to determine the effect gastroprotector of ethanolic extract of Clinopodium bolivianum on gastric injuries induced in mice, were used 36 albino male mice Balb/C, between 30-35 g, previously fasted for 24 h, only with water ad libitum. The gastric were injuries induced with indomethacin 2,5 mg/Kg (s.c.) one hour before administering the extract, complementing 20 minutes after with ethanol 96%, 0,1 mL orally. The experimental design was composed by: G1 negative control; G2 positive control; G3 ranitidine 50 mg Kg; G4, G5 y G6 extract 50, 150 y 300 mg/kg, respectively. An hour later, the stomachs were extracted and evaluated as harmful signs: inflammation, hemorrhagic bands and gastric ulcer; and then histological studies were performed. In the results Inca muña ethanolic extract showed secondary metabolites as phenolic compounds, flavonoids, triterpenos and ...

El objetivo del presente estudio fue determinar el efecto gastroprotector del extracto etanólico de Clinopodium bolivianum “inca muña” en lesiones gástricas inducidas en ratones. Se utilizaron 36 ratones albinos machos de la cepa Balb/C, de peso entre 30-35 g, previamente mantenidos en ayuno 24 h, solo con agua ad libitum. Las lesiones gástricas fueron inducidas con indometacina 2,5 mg/Kg (s.c.) una hora antes de administrar el extracto, complementando luego de 20 minutos con etanol 96%, 0,1 mL por vía oral. El diseño experimental estuvo conformado por: G1 control negativo; G2 control positivo; G3 ranitidina 50 mg/Kg; G4, G5 y G6 extracto de inca muña a dosis de 50, 150 y 300 mg/kg, respectivamente. Una hora después se extrajeron los estómagos y se evaluaron signos lesivos como: inflamación, bandas hemorrágicas y úlcera gástrica, y luego se realizaron estudios histológi...