Resultados de Búsqueda por Autor

1

artículo

Child maltreatment and resilience in adulthood: a protocol for a systematic review and meta-analysis

Publicado por
Fares-Otero, Natalia E., O, Jiaqing, Spies, Georgina, Womersley, Jacqueline S., Gonzalez, Carolina, Ayas, Görkem, Mossie, Tilahun Belete, Carranza-Neira, Julia, Estrada-Lorenzo, Jose Manuel, Vieta, Eduard, Schalinski, Inga, Schnyder, Ulrich, Seedat, Soraya

Publicado 2023

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Background: Although child maltreatment (CM) has been linked to health problems and poor psychosocial functioning, not all individuals exposed to CM develop or experience negative consequences later in life. This suggests that some individuals show resilience after being exposed to CM. However, conclusions have been limited by inconsistent findings across different CM subtypes and resilience domains. Objective: To develop a protocol for conducting a systematic review and meta-analysis to quantify associations between CM (overall and its subtypes) and resilience (global and its multiple domains) in adulthood, and to examine moderators and mediators of these associations. Method: PubMed, PsycINFO, Embase, Scopus, and Web of Science will be searched to identify relevant studies on the association between CM (exposure) and resilience (outcome) in adults (≥ 18 years). Data will be screened ...

2

artículo

Childhood Maltreatment and Somatic Symptoms in Adulthood: Establishing a New Research Pathway

Publicado por
Lüönd, Antonia M., Ayas, Görkem, Bachem, Rahel, Carranza-Neira, Julia, Eberle, David J., Fares-Otero, Natalia E., Hashim, Mohammad, Iqbal, Naved, Jenkins, Dan, Kamari Songhorabadi, Saman, Ledermann, Katharina, Makhashvili, Nino, Martin Soelch, Chantal, Nebioğlu, Ertaç, Oe, Misari, Olayinka, Juliet N., Olff, Miranda, Picot, Laura, Seedat, Soraya, Tandon, Tanya, Wadji, Dany L., Womersley, Jacqueline S., Schnyder, Ulrich, Sar, Vedat, Pfaltz, Monique C., Ceylan, Deniz

Publicado 2025

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Background: Somatic symptoms, such as chronic pain, fatigue, and gastrointestinal disturbances, are commonly reported in individuals with a history of childhood maltreatment (CM), which includes various forms of abuse and neglect experienced before age 18. Although CM is strongly associated with somatic symptoms, the specific relationships between CM subtypes and these symptoms, as well as the mechanisms connecting them, remain insufficiently understood. This review examines the complex interaction between CM and somatic symptoms, which often coexist with mental disorders and significantly impact quality of life and healthcare systems. Summary: Somatic symptoms, frequently a mix of "explained" and "unexplained" conditions, are associated with personal distress and pose diagnostic challenges. CM has been linked to these symptoms through neurobiological mechanisms, such as HPA axis dysregu...

3

artículo

Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Publicado por
Shen, Jie, Valentim, Wander, Friligkou, Eleni, Overstreet, Cassie, Choi, Karmel W., Koller, Dora, O’Donnell, Christopher J., Stein, Murray B., Gelernter, Joel, Koenen, Karestan C., Ressler, Kerry J., Zwart, John Anker, Zoellner, Lori A., Zhao, Hongyu, Zervas, Mark, Zai, Gwyneth C., Zai, Clement C., Young, Keith A., Young, Ross Mc D., Yehuda, Rachel, Xiong, Ying, Xia, Yan, Wolf, Christiane, Wolf, Erika J., Winternitz, Sherry, Winsvold, Bendik S., Williamson, Douglas E., Williams, Michelle A., Werge, Thomas, Wendt, Frank R., Weber, Heike, Waszczuk, Monika, Wang, Yunpeng, Wang, Zhewu, Voisey, Joanne, Vinkers, Christiaan H., Vermetten, Eric, van Rooij, Sanne J.H., Van Hooff, Miranda, van den Heuvel, Leigh Luella, Valdimarsdóttir, Unnur, Ursano, Robert J., Uddin, Monica, Trapido, Edward, Tiwari, Arun K., Thompson, Wesley K., Teicher, Martin H., Sumner, Jennifer A., Stevens, Jennifer S., Stensland, Synne, Stein, Dan J., Sponheim, Scott R., Smoller, Jordan W., Smith, Alicia K., Silove, Derrick, Sheerin, Christina M., Shabalin, Andrey, Seng, Julia S., Seedat, Soraya, Seah, Carina, Santoro, Marcos, Sanchez, Sixto E., Sampson, Laura, Salum, Giovanni Abrahão, de Viteri, Stacey Saenz, Rutten, Bart P.F., Runz, Heiko, Rung, Ariane, Ruggiero, Kenneth J., Roy-Byrne, Peter, Rothbaum, Alex O., Rothbaum, Barbara O., Roberts, Andrea L., Risbrough, Victoria B., Ratanatharathorn, Andrew, Qin, Xue Jun, Powers, Abigail, Porjesz, Bernice, Polusny, Melissa A., Pietrzak, Robert H., Peverill, Matthew, Peterson, Alan L., Peters, Edward S., Panizzon, Matthew S., Pan, Pedro M., Orcutt, Holly K., O’Donnell, Meaghan, Nugent, Nicole R., Norman, Sonya B., Nordentoft, Merete, Nelson, Elliot C., Mufford, Mary S., Mortensen, Preben Bo, Mors, Ole, Morris, Charles Phillip, Morey, Rajendra A., Miller, Mark W., Milberg, William, Milani, Lili, Mikita, Elizabeth A.

Publicado 2025

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Patients with post-traumatic stress disorder face increased cardiovascular risk. This study examines shared genetic regions between post-traumatic stress disorder and 246 cardiovascular conditions across electronic health records, 82 cardiac imaging, and health behaviors defined by Life’s Essential 8. Post-traumatic stress disorder is genetically correlated with cardiovascular diagnoses in 33 regions, imaging traits in 4 regions, and health behaviors in 44 regions. Potentially shared causal variants between post-traumatic stress disorder and 17 cardiovascular conditions were observed in 11 regions. Subsequent observational analysis in AllofUS cohort showed post-traumatic stress disorder is associated with 13 diagnoses even after accounting for socioeconomic factors and depression. Genetically regulated proteome expression in brain and blood tissues identified 33 blood and 122 brain gen...