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1
artículo
Publicado por
Shen, Jie, Valentim, Wander, Friligkou, Eleni, Overstreet, Cassie, Choi, Karmel W., Koller, Dora, O’Donnell, Christopher J., Stein, Murray B., Gelernter, Joel, Koenen, Karestan C., Ressler, Kerry J., Zwart, John Anker, Zoellner, Lori A., Zhao, Hongyu, Zervas, Mark, Zai, Gwyneth C., Zai, Clement C., Young, Keith A., Young, Ross Mc D., Yehuda, Rachel, Xiong, Ying, Xia, Yan, Wolf, Christiane, Wolf, Erika J., Winternitz, Sherry, Winsvold, Bendik S., Williamson, Douglas E., Williams, Michelle A., Werge, Thomas, Wendt, Frank R., Weber, Heike, Waszczuk, Monika, Wang, Yunpeng, Wang, Zhewu, Voisey, Joanne, Vinkers, Christiaan H., Vermetten, Eric, van Rooij, Sanne J.H., Van Hooff, Miranda, van den Heuvel, Leigh Luella, Valdimarsdóttir, Unnur, Ursano, Robert J., Uddin, Monica, Trapido, Edward, Tiwari, Arun K., Thompson, Wesley K., Teicher, Martin H., Sumner, Jennifer A., Stevens, Jennifer S., Stensland, Synne, Stein, Dan J., Sponheim, Scott R., Smoller, Jordan W., Smith, Alicia K., Silove, Derrick, Sheerin, Christina M., Shabalin, Andrey, Seng, Julia S., Seedat, Soraya, Seah, Carina, Santoro, Marcos, Sanchez, Sixto E., Sampson, Laura, Salum, Giovanni Abrahão, de Viteri, Stacey Saenz, Rutten, Bart P.F., Runz, Heiko, Rung, Ariane, Ruggiero, Kenneth J., Roy-Byrne, Peter, Rothbaum, Alex O., Rothbaum, Barbara O., Roberts, Andrea L., Risbrough, Victoria B., Ratanatharathorn, Andrew, Qin, Xue Jun, Powers, Abigail, Porjesz, Bernice, Polusny, Melissa A., Pietrzak, Robert H., Peverill, Matthew, Peterson, Alan L., Peters, Edward S., Panizzon, Matthew S., Pan, Pedro M., Orcutt, Holly K., O’Donnell, Meaghan, Nugent, Nicole R., Norman, Sonya B., Nordentoft, Merete, Nelson, Elliot C., Mufford, Mary S., Mortensen, Preben Bo, Mors, Ole, Morris, Charles Phillip, Morey, Rajendra A., Miller, Mark W., Milberg, William, Milani, Lili, Mikita, Elizabeth A.
Publicado 2025 Enlace
Patients with post-traumatic stress disorder face increased cardiovascular risk. This study examines shared genetic regions between post-traumatic stress disorder and 246 cardiovascular conditions across electronic health records, 82 cardiac imaging, and health behaviors defined by Life’s Essential 8. Post-traumatic stress disorder is genetically correlated with cardiovascular diagnoses in 33 regions, imaging traits in 4 regions, and health behaviors in 44 regions. Potentially shared causal variants between post-traumatic stress disorder and 17 cardiovascular conditions were observed in 11 regions. Subsequent observational analysis in AllofUS cohort showed post-traumatic stress disorder is associated with 13 diagnoses even after accounting for socioeconomic factors and depression. Genetically regulated proteome expression in brain and blood tissues identified 33 blood and 122 brain gen...
2
artículo
Publicado por
He, Qiang, Wang, Wenjing, Xu, Dingkang, Xiong, Yang, Tao, Chuanyuan, You, Chao, Ma, Lu, Ma, Junpeng, Nievergelt, Caroline M., Maihofer, Adam X., Klengel, Torsten, Atkinson, Elizabeth G., Chen, Chia Yen, Choi, Karmel W., Coleman, Jonathan R.I., Dalvie, Shareefa, Duncan, Laramie E., Logue, Mark W., Provost, Allison C., Ratanatharathorn, Andrew, Stein, Murray B., Torres, Katy, Aiello, Allison E., Almli, Lynn M., Amstadter, Ananda B., Andersen, Søren B., Andreassen, Ole A., Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegovic, Esmina, Babić, Dragan, Bækvad-Hansen, Marie, Baker, Dewleen G., Beckham, Jean C., Bierut, Laura J., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Børglum, Anders D., Bradley, Bekh, Brashear, Megan, Breen, Gerome, Bryant, Richard A., Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Calabrese, Joseph R., Caldas-de-Almeida, José M., Dale, Anders M., Daly, Mark J., Daskalakis, Nikolaos P., Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Disner, Seth G., Domschke, Katharina, Dzubur-Kulenovic, Alma, Erbes, Christopher R., Evans, Alexandra, Farrer, Lindsay A., Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gelaye, Bizu, Gelernter, Joel, Geuze, Elbert, Gillespie, Charles, Uka, Aferdita Goci, Gordon, Scott D., Guffanti, Guia, Hammamieh, Rasha, Harnal, Supriya, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M.J., Hougaard, David Michael, Jakovljevic, Miro, Jett, Marti, Johnson, Eric Otto, Jones, Ian, Jovanovic, Tanja, Qin, Xue Jun, Junglen, Angela G., Karstoft, Karen Inge, Kaufman, Milissa L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kranzler, Henry R., Kremen, William S., Lawford, Bruce R., Lebois, Lauren A.M., Lewis, Catrin E., Linnstaedt, Sarah D., Lori, Adriana
Publicado 2024 Enlace
Background: The causal effects of gut microbiome and the development of posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential causal association using mendelian randomization (MR). Methods: The summary-level statistics for gut microbiome were retrieved from a genome-wide association study (GWAS) of the MiBioGen consortium. As to PTSD, the Freeze 2 datasets were originated from the Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group (PGC-PTSD), and the replicated datasets were obtained from FinnGen consortium. Single nucleotide polymorphisms meeting MR assumptions were selected as instrumental variables. The inverse variance weighting (IVW) method was employed as the main approach, supplemented by sensitivity analyses to evaluate potential pleiotropy and heterogeneity and ensure the robustness of the MR results. We also...