Monkeypox is a reemerging zoonosis caused by the monkeypox virus (MPXV), which belongs to the poxviridae family, to the orthopoxvirus genus. It was first identified in 1958, since then there have been outbreaks in different countries of the African continent. However, it is verified that the pathogen has evolved, due to the presence of genomic polymorphism, loss of genes, etc. Until reaching clade IIb, which has caused the outbreak in 2022. Among the factors that have influenced its phylogenetics, the following have been identified: biogeographical barriers, drastic climatic variations and human actions. The latter depend on the relationship of the person with their natural environment, among them are: the destruction of forest areas, consumption of wild animals and the trafficking of species. These activities, in addition to violating the rights of the person such as a healthy environme...

Los receptores NOTCH se expresan en los macrófagos durante el proceso inflamatorio tras la activación de diferentes receptores, como el receptor TLR4, en respuesta a estímulos proinflamatorios tales como el LPS. La activación de los receptores da origen a señales moleculares que llevan a la activación de numerosos genes diana, así como también al aumento de la expresión y la activación de factores de transcripción como NF-B, que a su vez favorece la expresión de citocinas proinflamatorias. La implicación de las proteínas NOTCH y sus ligandos en la activación del macrófago durante la inflamación se ha descrito especialmente en modelos murinos, pero existen pocos datos con células humanas. En este trabajo se pretendió analizar el papel de la vía de señalización de NOTCH durante el proceso de inflamación en macrófagos humanos, con el fin de precisar si se corresponde...

Objetivo. Establecer la relación clonal de cepas de Escherichia coli productoras de BLEE de pacientes con ITU de origen comunitario (ITUc) y de portadores fecales humanos. Hospital Regional Lambayeque, noviembre 2015 – noviembre 2016. Materiales y métodos. Se identificaron las cepas de E. coli productoras de BLEE aisladas de orina y de heces de los pacientes con ITUc y de portadores (pacientes y sus familiares), respectivamente, empleando el medio de MacConkey suplementado con cefotaxima, pruebas bioquímicas y el método de Jarlier. Se hizo la caracterización molecular mediante dos variantes de la técnica rep-PCR; se obtuvieron los dendrogramas referidos, con la unión de ambos marcadores; se realizó la validación de los datos y se empleó el AMOVA. Resultados. Se obtuvo un 20,7 % (18/87) y un 87,8 % (36/41) de cepas de E. coli productoras de BLEE de pacientes con ITUc y de paci...

Objective: Describe self-medication and its relationship with sociodemographic characteristics in students of the medical school of a university in northern Peru 2023. Methodology: An observational, cross-sectional and prospective design was used with 301 participants, using the CAuM-ovr questionnaire to collect data. Results: 83.4% of the students self-medicated. The bivariate analysis revealed that belonging to medical school significantly increased the probability of self-medication (p=0.0001, OR=26.4), as did having a salary greater than 1,500 soles (p=0.01, OR= 2,26). The main reasons included symptoms not considered serious enough to see a doctor (39%). Regarding the level of knowledge, a high percentage (94.8%) did not request information about medications and 94% believed in the influence of advertising on their purchasing decisions. Attitudinally, 60.6% occasionally consulted a ...

Objective: To determine the clonality pattern assessed by ERIC-PCR and REP-PCR in extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae isolates from patients with urinary tract infections at the Hospital Regional Lambayeque (HRL) from July to November 2015. Materials and methods: A total of 30 ESBL-producing E. coli and K. pneumoniae clinical isolates collected from the HRL’s emergency, medicine, surgery and pediatrics services were assessed. The clonal relationship was determined using the ERIC-PCR and REP-PCR markers. For clusters, UPGMA algorithm with Bio Rad Quantity One 1-D analysis software was used, thus generating dendrograms through the union of the electrophoretic profiles obtained by both molecular markers. Results: From the molecular analysis, three predominant clonal patterns were found in E. coli and two in K. pneumoniae. Conclusion...