The objectives of this study were to determine the main groups of secondary metabolites in the ethanol extract of the leaves and the fruit juice of Passiflora edulis, and in vitro antioxidant activity of methanol extract of the leaves. The phytochemical screening was done following the usual techniques of chemistry; and for antioxidant activity using 1,1-diphenyl-2-picryl-hidrazil (DPPH) and four sample concentrations: 200, 100, 50 and 10 ).µg 1 ml, the absorbance was measured at a wavelength of 517 nm. We calculated the concentration of the extract caused a 50% decrease in absorbance of the solution of OPPH (IC 50). We found in leaves and fruit juice the presence of tannins, flavonoids, saponins, coumarins, quinones and alkaloids. Antioxidant capacity was observed dose-dependent, so an IC50 = 124 mg 1 ml. lt is concluded that the diverse secondary metabolites are found in both leaves a...

The objectives of this study were to determine the main groups of secondary metabolites in the ethanol extract of the leaves and the fruit juice of Passiflora edulis, and in vitro antioxidant activity of methanol extract of the leaves. The phytochemical screening was done following the usual techniques of chemistry; and for antioxidant activity using 1,1-diphenyl-2-picryl-hidrazil (DPPH) and four sample concentrations: 200, 100, 50 and 10 ).µg 1 ml, the absorbance was measured at a wavelength of 517 nm. We calculated the concentration of the extract caused a 50% decrease in absorbance of the solution of OPPH (IC 50). We found in leaves and fruit juice the presence of tannins, flavonoids, saponins, coumarins, quinones and alkaloids. Antioxidant capacity was observed dose-dependent, so an IC50 = 124 mg 1 ml. lt is concluded that the diverse secondary metabolites are found in both leaves a...

By simulation with the Molecular Dynamics method and the thermal temper technique, the more stablegeometric structures and their respective energy were determined in the Nin Alm (n + m = 13)nanoclusters. The atomic interaction in the cluster was modelized with the Embeded Atom Method (EAM)(the Voter & Chen version). The most stable geometric structures of the cluster and their minimal energywere obtained from 200 generating spatial coordinates along the high energy path. The initial internalenergy is higher than the melting temperature of the cluster. The thermal temper technique was neededto remove slowly the internal kinetic energy from the clusters. The more stable clusters have a regularicosahedral geometrical structure.

Mediante la simulación con el método de Dinámica Molecular y la técnica del temple térmico se han determinado las estructuras geométricas más estables, y sus respectivas energías, de los nanoclusters de NinAlm (n + m = 13). La interacción entre los átomos del cluster se modela mediante el método del potencial del átomo insertado (EAM), en la versión de Voter y Chen. Las estructuras geométricas más estables de los clusters y sus energías mínimas fueron obtenidas a partir de 200 coordenadas del espacio de fases generadoras a lo largo de las trayectorias de altas energías. La energía interna inicial es superior a la temperatura de fusión de los clusters. Se utiliza la técnica del temple térmico con la finalidad de remover lentamente la energía cinética interna de los clusters. Los nanoclusters más estables poseen una estructura geométrica de icosaedro regular.

Antecedentes: Se ha reportado una disminución de la eficacia antiparasitaria del triclabendazol en el control de Fasciola hepatica en vacas lecheras en el valle de Cajamarca, Perú. Objetivo: Determinar la eficacia antihelmíntica de cuatro antiparasitarios en un área más amplia de la provincia de Cajamarca. Métodos: Se seleccionaron cuatro predios ganaderos de tres provincias de la región Cajamarca. En cada predio se seleccionaron 60 hembras bovinas infectadas naturalmente por F. hepatica. Cada predio se dividió en cuatro grupos homogéneos según los individuos y la carga parasitaria. Los grupos fueron: triclabendazol (12 mg/kg de PV, VO), clorsulon/ivermectina (2 mg/kg y 0,2 mg/kg de PV, SC, respectivamente), closantel (10 mg/kg de PV, VO), y nitroxinil (10 mg/kg de PV, SC). La eficacia se determinó siguiendo las directrices de la WAAVP al medir la reducción en puesta de huevo...

El presente trabajo fue realizado en la Clínica IPSS "Luis Negreiros Vega" (INV), con el objeto de evaluar el impacto en la atención médica de los programas Preventivos Promocionales de Salud. Intenta proponer un modelo de evaluación del Impacto en Salud que los programas han generado desde su creación. Para ello hemos realizado un estudio de corte longitudinal desde el año 1992 al primer semestre de 1995, con estudio de casos y controles, y la evaluación de la calidad de atención en los mismos con indicadores e instrumentos de evaluación. Se han encontrado programas que originaron un gran impacto positivo en la Atención Médica y fue logrado por los programas: Control de Enfermedades Diarreicas Agudas, Hipertensión Arterial, Medicina Alternativa, Salud Ocupacional y Salud Oral, disminuyendo la concentración en la atención por consultorios externos, y el consumo de medicamen...

Background. Breast cancer is an important cause of cancer-related death in women worldwide and represents the second most frequent cause of brain metastases after lung cancer. The aim of this study was to determine the characteristics and outcomes of triple-negative breast cancer (TNBC) patients with brain metastasis (BM). Methods. We retrospectively reviewed a cohort of patients diagnosed with TNBC at the "Instituto Nacional de Enfermedades Neoplasicas"(period 2000-2014) to evaluate patients who developed BM. Survival rates were assessed by the Kaplan-Meier method, and prognostic factors were identified with the Cox regression analysis. Results. Of a total of 2007 TNBC patients, 193 (9.62%) developed BM. Of these, 169 stages I-III patients with a median age of 45 years (range:21-78) were included. The stage in this cohort was 4 (2.4%) clinical stage (CS) I, 23 (13.6%) with CS ...

Background Evidence regarding differences in survival associated with the site of metastasis in triplenegative breast cancer (TNBC) remains limited. Our aim was to analyze the overall survival (OS), distant relapse free survival (DRFS), and survival since the diagnosis of the relapse (MS), according to the side of metastasis. Methods This was a retrospective study of TNBC patients with distant metastases at the Instituto Nacional de Enfermedades Neoplasicas (Lima, Peru) from 2000 to 2014. Prognostic factors were determined by multivariate Cox regression analysis. Results In total, 309 patients were included. Regarding the type of metastasis, visceral metastasis accounted for 41% and the lung was the most frequent first site of metastasis (33.3%). With a median follow-up of 10.2 years, the 5-year DRFS and OS were 10% and 26%, respectively. N staging (N2-N3 vs. N0, HR = 1.49, 95%CI: 1.04-2...